CL18C_HUMAN
ID CL18C_HUMAN Reviewed; 446 AA.
AC Q8NCF0; Q8IUW8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=C-type lectin domain family 18 member C;
DE AltName: Full=Mannose receptor-like protein 3;
DE Flags: Precursor;
GN Name=CLEC18C; Synonyms=MRLP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=26170455; DOI=10.1074/jbc.m115.649814;
RA Huang Y.L., Pai F.S., Tsou Y.T., Mon H.C., Hsu T.L., Wu C.Y., Chou T.Y.,
RA Yang W.B., Chen C.H., Wong C.H., Hsieh S.L.;
RT "Human CLEC18 gene cluster contains C-type lectins with differential
RT glycan-binding specificity.";
RL J. Biol. Chem. 290:21252-21263(2015).
CC -!- FUNCTION: Binds polysaccharidesin a Ca(2+)-independent manner with a
CC preferentially binding to fucoidan, beta-glucans and galactans.
CC {ECO:0000269|PubMed:26170455}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5D8T8}.
CC Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus
CC {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NCF0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCF0-2; Sequence=VSP_032206, VSP_032207;
CC -!- TISSUE SPECIFICITY: Detected in peripheral blood cells.
CC {ECO:0000269|PubMed:26170455}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39068.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK074773; BAC11199.1; -; mRNA.
DR EMBL; BC039068; AAH39068.1; ALT_INIT; mRNA.
DR CCDS; CCDS32473.1; -. [Q8NCF0-1]
DR RefSeq; NP_775890.2; NM_173619.3. [Q8NCF0-1]
DR AlphaFoldDB; Q8NCF0; -.
DR SMR; Q8NCF0; -.
DR BioGRID; 129716; 1.
DR IntAct; Q8NCF0; 1.
DR STRING; 9606.ENSP00000477846; -.
DR GlyGen; Q8NCF0; 1 site.
DR iPTMnet; Q8NCF0; -.
DR PhosphoSitePlus; Q8NCF0; -.
DR BioMuta; CLEC18C; -.
DR DMDM; 172045775; -.
DR MassIVE; Q8NCF0; -.
DR PaxDb; Q8NCF0; -.
DR PeptideAtlas; Q8NCF0; -.
DR PRIDE; Q8NCF0; -.
DR ProteomicsDB; 72885; -. [Q8NCF0-1]
DR Antibodypedia; 66794; 69 antibodies from 15 providers.
DR DNASU; 283971; -.
DR Ensembl; ENST00000314151.12; ENSP00000326538.8; ENSG00000157335.21. [Q8NCF0-1]
DR Ensembl; ENST00000541793.7; ENSP00000444875.2; ENSG00000157335.21. [Q8NCF0-1]
DR Ensembl; ENST00000569347.6; ENSP00000455920.2; ENSG00000157335.21. [Q8NCF0-1]
DR Ensembl; ENST00000618957.4; ENSP00000477846.1; ENSG00000157335.21. [Q8NCF0-1]
DR GeneID; 283971; -.
DR KEGG; hsa:283971; -.
DR MANE-Select; ENST00000541793.7; ENSP00000444875.2; NM_173619.4; NP_775890.2.
DR UCSC; uc002eyk.3; human. [Q8NCF0-1]
DR CTD; 283971; -.
DR GeneCards; CLEC18C; -.
DR HGNC; HGNC:28538; CLEC18C.
DR HPA; ENSG00000157335; Group enriched (kidney, testis).
DR MIM; 616573; gene.
DR neXtProt; NX_Q8NCF0; -.
DR PharmGKB; PA164718038; -.
DR VEuPathDB; HostDB:ENSG00000157335; -.
DR eggNOG; KOG3017; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00900000141128; -.
DR InParanoid; Q8NCF0; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q8NCF0; -.
DR TreeFam; TF350472; -.
DR PathwayCommons; Q8NCF0; -.
DR SignaLink; Q8NCF0; -.
DR BioGRID-ORCS; 283971; 73 hits in 982 CRISPR screens.
DR GenomeRNAi; 283971; -.
DR Pharos; Q8NCF0; Tdark.
DR PRO; PR:Q8NCF0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8NCF0; protein.
DR Bgee; ENSG00000157335; Expressed in adult mammalian kidney and 87 other tissues.
DR ExpressionAtlas; Q8NCF0; baseline and differential.
DR Genevisible; Q8NCF0; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB.
DR GO; GO:0005768; C:endosome; TAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; TAS:UniProtKB.
DR GO; GO:0030247; F:polysaccharide binding; IDA:UniProtKB.
DR Gene3D; 3.10.100.10; -; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; EGF-like domain;
KW Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Lectin;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..446
FT /note="C-type lectin domain family 18 member C"
FT /id="PRO_0000324317"
FT DOMAIN 52..182
FT /note="SCP"
FT DOMAIN 228..261
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 306..433
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 236..249
FT /evidence="ECO:0000250"
FT DISULFID 251..260
FT /evidence="ECO:0000250"
FT DISULFID 327..432
FT /evidence="ECO:0000250"
FT DISULFID 408..424
FT /evidence="ECO:0000250"
FT VAR_SEQ 329..339
FT /note="RKGGVLAQIKS -> VTVTPSFLGTP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032206"
FT VAR_SEQ 340..446
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032207"
FT CONFLICT 69
FT /note="M -> R (in Ref. 2; AAH39068)"
FT /evidence="ECO:0000305"
FT CONFLICT 91
FT /note="I -> T (in Ref. 1; BAC11199)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="L -> P (in Ref. 1; BAC11199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 49585 MW; 6E4D566B5A62782F CRC64;
MLHPETSPGR GHLLAVLLAL LGTAWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS
WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF
VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQAAIEAFVC
AYSPRGNWEV NGKTIVPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG
RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI
DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGFGNCVE LQASAAFNWN
NQRCKTRNRY ICQFAQEHIS RWGPGS
