CL19A_HUMAN
ID CL19A_HUMAN Reviewed; 136 AA.
AC Q6UXS0; Q0VF32;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=C-type lectin domain family 19 member A;
DE Flags: Precursor;
GN Name=CLEC19A; ORFNames=UNQ5810/PRO19627;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXS0; O94888: UBXN7; NbExp=3; IntAct=EBI-12192919, EBI-1993627;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AY358232; AAQ88599.1; -; mRNA.
DR EMBL; BC119018; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q6UXS0; -.
DR SMR; Q6UXS0; -.
DR IntAct; Q6UXS0; 1.
DR STRING; 9606.ENSP00000455948; -.
DR GlyGen; Q6UXS0; 1 site.
DR BioMuta; CLEC19A; -.
DR DMDM; 74738256; -.
DR PaxDb; Q6UXS0; -.
DR PeptideAtlas; Q6UXS0; -.
DR PRIDE; Q6UXS0; -.
DR Antibodypedia; 66230; 7 antibodies from 7 providers.
DR Ensembl; ENST00000465414.1; ENSP00000455948.1; ENSG00000261210.8.
DR UCSC; uc002dga.6; human.
DR GeneCards; CLEC19A; -.
DR HGNC; HGNC:34522; CLEC19A.
DR HPA; ENSG00000261210; Tissue enriched (brain).
DR neXtProt; NX_Q6UXS0; -.
DR OpenTargets; ENSG00000261210; -.
DR VEuPathDB; HostDB:ENSG00000261210; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000163133; -.
DR HOGENOM; CLU_2066807_0_0_1; -.
DR InParanoid; Q6UXS0; -.
DR PhylomeDB; Q6UXS0; -.
DR TreeFam; TF344047; -.
DR PathwayCommons; Q6UXS0; -.
DR SignaLink; Q6UXS0; -.
DR ChiTaRS; CLEC19A; human.
DR Pharos; Q6UXS0; Tdark.
DR PRO; PR:Q6UXS0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UXS0; protein.
DR Bgee; ENSG00000261210; Expressed in right uterine tube and 46 other tissues.
DR ExpressionAtlas; Q6UXS0; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..136
FT /note="C-type lectin domain family 19 member A"
FT /id="PRO_0000317515"
FT DOMAIN 47..136
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CONFLICT 16
FT /note="S -> A (in Ref. 2; BC119018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 15448 MW; BBA4D4952E00F5F4 CRC64;
MQRWTLWAAA FLTLHSAQAF PQTDISISPA LPELPLPSLC PLFWMEFKGH CYRFFPLNKT
WAEADLYCSE FSVGRKSAKL ASIHSWEENV FVYDLVNSCV PGIPADVWTG LHDHRQVRKQ
WPLGPLGSSS QDSILI
