CL20A_HUMAN
ID CL20A_HUMAN Reviewed; 400 AA.
AC Q6ZU45; A0A1B0GWE9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative C-type lectin domain family 20 member A;
DE Flags: Precursor;
GN Name=CLEC20A {ECO:0000312|HGNC:HGNC:34521};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86382.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AL035702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK125993; BAC86382.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q6ZU45; -.
DR SMR; Q6ZU45; -.
DR BioMuta; CLEC20A; -.
DR DMDM; 74723026; -.
DR PeptideAtlas; Q6ZU45; -.
DR PRIDE; Q6ZU45; -.
DR Ensembl; ENST00000623247.2; ENSP00000490899.1; ENSG00000188585.9.
DR MANE-Select; ENST00000623247.3; ENSP00000490899.1; NM_001395331.1; NP_001382260.1.
DR GeneCards; CLEC20A; -.
DR HGNC; HGNC:34521; CLEC20A.
DR HPA; ENSG00000188585; Tissue enhanced (lymphoid tissue, testis).
DR neXtProt; NX_Q6ZU45; -.
DR OpenTargets; ENSG00000188585; -.
DR VEuPathDB; HostDB:ENSG00000188585; -.
DR GeneTree; ENSGT00390000009002; -.
DR InParanoid; Q6ZU45; -.
DR OMA; DLQMVTD; -.
DR PhylomeDB; Q6ZU45; -.
DR Pharos; Q6ZU45; Tdark.
DR PRO; PR:Q6ZU45; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6ZU45; protein.
DR Bgee; ENSG00000188585; Expressed in left testis and 36 other tissues.
DR ExpressionAtlas; Q6ZU45; baseline and differential.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.100.10; -; 2.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 2.
DR SMART; SM00034; CLECT; 2.
DR SUPFAM; SSF56436; SSF56436; 2.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Lectin; Reference proteome; Repeat; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..400
FT /note="Putative C-type lectin domain family 20 member A"
FT /evidence="ECO:0000255"
FT /id="PRO_5008408763"
FT DOMAIN 26..131
FT /note="C-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DOMAIN 159..275
FT /note="C-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 287..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 40..130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 105..122
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 180..274
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 248..266
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 400 AA; 44255 MW; 83C8E223E81B0B46 CRC64;
MLPRALLLSF CAAALQLVSS KRDLVLVKEA LSWYDAQQHC RLHYTDLADL QPSGLWKLYS
LMTSTPAWIG LFFDASTSGL RWSSGSTFTA LEWGQKLPEF GVGFCATLYT WLKLPSIGAA
SCTAQKPFLC YCDPDVGHLI STKPSLSLTT SPKPAVVQIS GQTFMRFDQV MTWSSALLYC
RSHHTDLADL QMVTDETGKE ALRSIMSETE AWIGLYLNAN SGSLSWSSDL GASIPSWLQV
PMMVRGLCTA LGIYMTYSPK VYSVNCSSLL PFFCFYDSST GHRASAELPP LFHTSPTEMT
EETTPRPGRA VASVGSGTDR RDTAAATEAQ HLSSESKEKT SAQKSGHPFG ILKADFTIST
LMDPEEMKDQ FLRQIQEVLK LTLGHEQFRL KWVSFEVNKK
