CL2D2_RAT
ID CL2D2_RAT Reviewed; 233 AA.
AC A4KWA5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=C-type lectin domain family 2 member D2;
GN Name=Clec2d2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=17462921; DOI=10.1016/j.immuni.2007.03.013;
RA Voigt S., Mesci A., Ettinger J., Fine J.H., Chen P., Chou W., Carlyle J.R.;
RT "Cytomegalovirus evasion of innate immunity by subversion of the NKR-
RT P1B:Ocil/Clr-b missing-self axis.";
RL Immunity 26:617-627(2007).
CC -!- FUNCTION: Lectin-type cell surface receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
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DR EMBL; EF100686; ABO15826.1; -; mRNA.
DR RefSeq; NP_001078871.1; NM_001085402.1.
DR RefSeq; XP_017448197.1; XM_017592708.1.
DR AlphaFoldDB; A4KWA5; -.
DR SMR; A4KWA5; -.
DR GlyGen; A4KWA5; 1 site.
DR Ensembl; ENSRNOT00000038801; ENSRNOP00000035114; ENSRNOG00000059890.
DR GeneID; 362445; -.
DR KEGG; rno:362445; -.
DR UCSC; RGD:1562831; rat.
DR CTD; 362445; -.
DR RGD; 1562831; Clec2d2.
DR GeneTree; ENSGT00940000155319; -.
DR HOGENOM; CLU_049894_8_1_1; -.
DR InParanoid; A4KWA5; -.
DR OMA; CRREKWN; -.
DR OrthoDB; 945977at2759; -.
DR PhylomeDB; A4KWA5; -.
DR TreeFam; TF351467; -.
DR PRO; PR:A4KWA5; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000059890; Expressed in ovary and 7 other tissues.
DR Genevisible; A4KWA5; RN.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="C-type lectin domain family 2 member D2"
FT /id="PRO_0000315292"
FT TOPO_DOM 1..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 119..228
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 233 AA; 25559 MW; EDB02A73EEB312EE CRC64;
MPSSAHLQDA PPLLSRTLTQ DEEQTSLRQS SSCGLSAASA SESLSGSTKS RIPHSKMLQG
NLPRIISPES PAKLPCCYGV IMVLSVAVVA LSVALSVKKT PQILTVKTYA ACPRNWIGVG
NKCYYFNETP SNWTFSQTLC KAQEAELARF DTEEELNFLK RHKGSSGYWI GLHRESSSQP
WKWTDNTAYN NLVPIGGDEK HGFLSDNGFS SGRGYIVRKS ICSKPNSYTS QCQ