ID   CL758_BUTOS             Reviewed;          64 AA.
AC   B8XH22;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Putative calcium channel toxin Tx758;
DE   Flags: Precursor;
OS   Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=539894;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zilberberg N., Kozminsky-Atias A.;
RT   "Buthus occitanus israelis scorpion toxin.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May increase intracellular calcium release through the
CC       activation of nuclear inositol 1,4,5-trisphosphate receptors (ITPR) of
CC       cardiomyocytes, thereby causing an increase in the contraction
CC       frequency of these cells. {ECO:0000250|UniProtKB:P0DM29}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P59868}.
CC   -!- SIMILARITY: Belongs to the scorpion calcin-like family. {ECO:0000305}.
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DR   EMBL; FJ360811; ACJ23131.1; -; mRNA.
DR   AlphaFoldDB; B8XH22; -.
DR   SMR; B8XH22; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Potassium channel impairing toxin;
KW   Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..27
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403854"
FT   PEPTIDE         28..64
FT                   /note="Putative calcium channel toxin Tx758"
FT                   /id="PRO_0000403855"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
FT   DISULFID        36..49
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
FT   DISULFID        42..58
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
SQ   SEQUENCE   64 AA;  7081 MW;  8EF329AEC2049F78 CRC64;
     MSTFVIVFLL LTAVLCHAEP ALDETARGCN RLNKKCNSDG DCCRYGERCI STGVNYYCKP
     DFGP