ID   CL8L_NEMVE              Reviewed;          78 AA.
AC   P0DQR8;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Protein Class8-like {ECO:0000303|PubMed:33060291};
DE   Flags: Precursor;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-58, IDENTIFICATION BY
RP   MASS SPECTROMETRY, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=33060291; DOI=10.1073/pnas.2011120117;
RA   Sachkova M.Y., Landau M., Surm J.M., Macrander J., Singer S.A.,
RA   Reitzel A.M., Moran Y.;
RT   "Toxin-like neuropeptides in the sea anemone Nematostella unravel
RT   recruitment from the nervous system to venom.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:27481-27492(2020).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=29739837; DOI=10.1242/dev.162867;
RA   Warner J.F., Guerlais V., Amiel A.R., Johnston H., Nedoncelle K.,
RA   Roettinger E.;
RT   "NvERTx: a gene expression database to compare embryogenesis and
RT   regeneration in the sea anemone Nematostella vectensis.";
RL   Development 145:0-0(2018).
CC   -!- FUNCTION: Probable neuropeptide. {ECO:0000305|PubMed:33060291}.
CC   -!- TISSUE SPECIFICITY: Expressed in ganglion neurons residing in the
CC       mesoglea (observed in both planulae and primary polyps). Not expressed
CC       in nematocytes. {ECO:0000269|PubMed:33060291}.
CC   -!- DEVELOPMENTAL STAGE: Is strongly detected in planulae, a little more
CC       detected in primary polyps (9d), and still a little more in both adult
CC       females and males (at protein level) (PubMed:33060291). Transcripts are
CC       expressed early in the life cycle and their expression is maintained
CC       through the adult stage (PubMed:29739837).
CC       {ECO:0000269|PubMed:29739837, ECO:0000269|PubMed:33060291}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/HADO01000486.1/";
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DR   SMR; P0DQR8; -.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Neuropeptide; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..36
FT                   /evidence="ECO:0000305|PubMed:33060291"
FT                   /id="PRO_0000453916"
FT   CHAIN           37..78
FT                   /note="Protein Class8-like"
FT                   /evidence="ECO:0000305|PubMed:33060291"
FT                   /id="PRO_0000453917"
FT   DOMAIN          38..78
FT                   /note="ShKT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        38..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        47..71
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        56..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
SQ   SEQUENCE   78 AA;  8532 MW;  3138A114C84D1BFD CRC64;
     MRTLVVLLIG AVLLCSANAF LDELLAESVN DMTDKRACFD KYKSNICGGV ISPAHCVRRS
     GRMAKFAKEN CAHFCGFC