CLA1_CAEEL
ID CLA1_CAEEL Reviewed; 8922 AA.
AC W6RTA4; H2KYL0; Q9BI65; W6RT96; W6SB84; W6SB91;
DT 07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 2.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Protein clarinet {ECO:0000303|PubMed:29160205};
GN Name=cla-1 {ECO:0000303|PubMed:29160205, ECO:0000312|WormBase:F45E4.3a};
GN Synonyms=tag-80 {ECO:0000312|WormBase:F45E4.3a};
GN ORFNames=F45E4.3 {ECO:0000312|WormBase:F45E4.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF 6751-PRO--GLY-8892.
RX PubMed=29160205; DOI=10.7554/elife.29276;
RA Xuan Z., Manning L., Nelson J., Richmond J.E., Colon-Ramos D.A., Shen K.,
RA Kurshan P.T.;
RT "Clarinet (CLA-1), a novel active zone protein required for synaptic
RT vesicle clustering and release.";
RL Elife 6:0-0(2017).
CC -!- FUNCTION: Required for synapse development in the active zone of
CC presynaptic terminals of specific neurons including serotonergic NSM
CC neurons (PubMed:29160205). The active zone is a protein-dense neuronal
CC region within the presynaptic bouton, from which synaptic vesicles send
CC neurotransmitter signals across the synapse (PubMed:29160205). Plays a
CC role in the recruitment and clustering of synaptic vesicles in the
CC active zone of presynaptic terminals in serotonergic NSM neurons, and
CC coordinates the release of synaptic vesicles at presynaptic terminals
CC to regulate neurotransmission at neuromuscular junctions
CC (PubMed:29160205). Regulates synapse number in inhibitory motor neurons
CC and plays a role in spontaneous postsynaptic synaptic vesicle release
CC in muscle cells (PubMed:29160205). {ECO:0000269|PubMed:29160205}.
CC -!- INTERACTION:
CC W6RTA4; Q19980: cat-4; NbExp=2; IntAct=EBI-2916517, EBI-311852;
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:29160205}. Cell
CC projection, axon {ECO:0000269|PubMed:29160205}. Note=Localization at
CC the synapse may depend on other active zone proteins such as syd-1 and
CC syd-2 (PubMed:29160205). Anchored via the C-terminus to the active
CC zone, a protein-dense region within the presynaptic bouton, of the
CC synaptic compartment (PubMed:29160205). The N-terminus extends away
CC from the active zone (PubMed:29160205). {ECO:0000269|PubMed:29160205}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=6;
CC Name=a {ECO:0000312|WormBase:F45E4.3a};
CC IsoId=W6RTA4-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F45E4.3b};
CC IsoId=W6RTA4-2; Sequence=VSP_059922, VSP_059923;
CC Name=c {ECO:0000312|WormBase:F45E4.3c};
CC IsoId=W6RTA4-3; Sequence=VSP_059921, VSP_059922, VSP_059923;
CC Name=d {ECO:0000312|WormBase:F45E4.3d};
CC IsoId=W6RTA4-4; Sequence=VSP_059921;
CC Name=e {ECO:0000312|WormBase:F45E4.3e};
CC IsoId=W6RTA4-5; Sequence=VSP_059920;
CC Name=f {ECO:0000312|WormBase:F45E4.3f};
CC IsoId=W6RTA4-6; Sequence=VSP_059920, VSP_059922, VSP_059923;
CC -!- TISSUE SPECIFICITY: Expressed in the nervous system.
CC {ECO:0000269|PubMed:29160205}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the nervous system from the three-
CC fold stage of embryonic development. {ECO:0000269|PubMed:29160205}.
CC -!- MISCELLANEOUS: [Isoform b]: Produced by alternative splicing.
CC {ECO:0000269|PubMed:29160205}.
CC -!- MISCELLANEOUS: [Isoform c]: Produced by alternative promoter usage and
CC alternative splicing. {ECO:0000269|PubMed:29160205}.
CC -!- MISCELLANEOUS: [Isoform d]: Produced by alternative promoter usage.
CC {ECO:0000269|PubMed:29160205}.
CC -!- MISCELLANEOUS: [Isoform e]: Produced by alternative promoter usage.
CC {ECO:0000269|PubMed:29160205}.
CC -!- MISCELLANEOUS: [Isoform f]: Produced by alternative promoter usage and
CC alternative splicing. {ECO:0000269|PubMed:29160205}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284604; CCD63778.1; -; Genomic_DNA.
DR EMBL; BX284604; CCD63779.1; -; Genomic_DNA.
DR EMBL; BX284604; CDM63472.1; -; Genomic_DNA.
DR EMBL; BX284604; CDM63473.1; -; Genomic_DNA.
DR EMBL; BX284604; CDM63478.2; -; Genomic_DNA.
DR EMBL; BX284604; CDM63477.2; -; Genomic_DNA.
DR RefSeq; NP_001294143.1; NM_001307214.1. [W6RTA4-3]
DR RefSeq; NP_001294144.1; NM_001307215.1. [W6RTA4-4]
DR RefSeq; NP_001294148.2; NM_001307219.2. [W6RTA4-1]
DR RefSeq; NP_001294149.2; NM_001307220.2. [W6RTA4-2]
DR RefSeq; NP_501237.1; NM_068836.3.
DR RefSeq; NP_501238.1; NM_068837.3.
DR SMR; W6RTA4; -.
DR IntAct; W6RTA4; 10.
DR STRING; 6239.F45E4.3a.1; -.
DR EPD; W6RTA4; -.
DR PaxDb; W6RTA4; -.
DR PeptideAtlas; W6RTA4; -.
DR EnsemblMetazoa; F45E4.3a.1; F45E4.3a.1; WBGene00018468. [W6RTA4-1]
DR EnsemblMetazoa; F45E4.3b.1; F45E4.3b.1; WBGene00018468. [W6RTA4-2]
DR EnsemblMetazoa; F45E4.3c.1; F45E4.3c.1; WBGene00018468. [W6RTA4-3]
DR EnsemblMetazoa; F45E4.3d.1; F45E4.3d.1; WBGene00018468. [W6RTA4-4]
DR EnsemblMetazoa; F45E4.3e.1; F45E4.3e.1; WBGene00018468. [W6RTA4-5]
DR EnsemblMetazoa; F45E4.3f.1; F45E4.3f.1; WBGene00018468. [W6RTA4-6]
DR GeneID; 177539; -.
DR KEGG; cel:CELE_F45E4.3; -.
DR UCSC; F45E4.3b.1; c. elegans.
DR CTD; 177539; -.
DR WormBase; F45E4.3a; CE51009; WBGene00018468; cla-1. [W6RTA4-1]
DR WormBase; F45E4.3b; CE51026; WBGene00018468; cla-1. [W6RTA4-2]
DR WormBase; F45E4.3c; CE49484; WBGene00018468; cla-1. [W6RTA4-3]
DR WormBase; F45E4.3d; CE49489; WBGene00018468; cla-1. [W6RTA4-4]
DR WormBase; F45E4.3e; CE24980; WBGene00018468; cla-1. [W6RTA4-5]
DR WormBase; F45E4.3f; CE24981; WBGene00018468; cla-1. [W6RTA4-6]
DR eggNOG; KOG1181; Eukaryota.
DR eggNOG; KOG2060; Eukaryota.
DR GeneTree; ENSGT00620000087961; -.
DR HOGENOM; CLU_222840_0_0_1; -.
DR OMA; TAVWMLY; -.
DR OrthoDB; 15051at2759; -.
DR PRO; PR:W6RTA4; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00018468; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0031045; C:dense core granule; IBA:GO_Central.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048786; C:presynaptic active zone; IDA:UniProtKB.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; IBA:GO_Central.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR GO; GO:0048790; P:maintenance of presynaptic active zone structure; IMP:UniProtKB.
DR GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
DR GO; GO:0098814; P:spontaneous synaptic transmission; IMP:UniProtKB.
DR GO; GO:0097091; P:synaptic vesicle clustering; IMP:UniProtKB.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IMP:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Cell projection;
KW Coiled coil; Reference proteome; Synapse.
FT CHAIN 1..8922
FT /note="Protein clarinet"
FT /id="PRO_0000445624"
FT DOMAIN 8570..8661
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 8714..8835
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 11..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1726..1801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1820..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2032..2084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2194..2213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2329..2403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2423..2497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2610..2684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2704..2845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2892..2963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2983..3155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3171..3249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3268..3337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3619..3639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3995..4079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4117..4169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4181..4271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4557..4624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4636..4656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4666..4685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4730..4801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4855..4899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5004..5036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5360..5379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5390..5413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5484..5511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5540..5572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6194..6303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6354..6437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6487..6510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6577..6609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6668..6691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6728..6768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6998..7018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7045..7098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7137..7175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7202..7263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7313..7350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7598..7623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7760..7797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7842..7881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8510..8562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 385..405
FT /evidence="ECO:0000255"
FT COILED 7895..7915
FT /evidence="ECO:0000255"
FT COMPBIAS 529..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1845..1859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1939..1953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2133..2147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2354..2368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2448..2462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2541..2555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2635..2649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2729..2743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2769..2789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2823..2837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2917..2931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3017..3031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3105..3119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3199..3213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3293..3307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4023..4037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4045..4079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4124..4138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4181..4197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4218..4240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4246..4271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4583..4598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4610..4624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4670..4684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4758..4772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4780..4801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4869..4885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5009..5030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5360..5374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5393..5410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5550..5572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6225..6284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6285..6303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6375..6419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6487..6504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6735..6757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7045..7068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7070..7090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7159..7175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7202..7226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7313..7330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7599..7613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8513..8534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..7691
FT /note="Missing (in isoform e and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_059920"
FT VAR_SEQ 1..6280
FT /note="Missing (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_059921"
FT VAR_SEQ 8516..8527
FT /note="ETALTSSNKIST -> GDNSPSFLIDGR (in isoform b, isoform
FT c and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_059922"
FT VAR_SEQ 8528..8922
FT /note="Missing (in isoform b, isoform c and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_059923"
FT MUTAGEN 6751..8892
FT /note="Missing: In wy1048; defective morphology of the
FT active zone region of the synapse, and abnormal clustering
FT and localization of synaptic vesicles at presynaptic
FT terminals of serotonergic NSM neurons. Defective synaptic
FT transmission at neuromuscular junctions with increased
FT sensitivity to the acetylcholinesterase inhibitor Aldicarb,
FT and a 46% reduction in the frequency of spontaneous
FT postsynaptic currents in postsynaptic muscle cells."
FT /evidence="ECO:0000269|PubMed:29160205"
SQ SEQUENCE 8922 AA; 1000209 MW; 6874549BD09F2F54 CRC64;
MSSWFSYFGF SKGPPLEEVR EESEEDAQVP EQVVSKNTEE EIADAINRLS PEQQNLIQDV
LRRAESSRKE AKVVVDAEMM RSRFRQRDSI EDSQEIDHRY SLIQMDSIPE NMVTNEMEER
LATTQNEDII PESSQRSPIT PRKIHEKRAS ITEVTTENLR HRFQKMKSHL TTWFNSLDYD
GEYIFDFTSK PEKSEKLGEL TMQYIDALSQ AIMISSHIEY SHHVLSSNPK FQQMCTQFCE
SIFSVAFDEL TYQLLDDKVQ ETLNEYCGQI AEEALQAAFF TMISKTLSKS KECEQVLNEI
SSMHKSRSFE SAKQLDQLLS RIEDDRESSR KSSPYLYEVL GKSSDSPSTS ASVEYRSQNS
YESEISFETP DIHVEELFDT HLNEKDETKL ILKSVEDKLE TTEIEGNVPK IDENLIENIQ
YDSGDQEHYI WISGPLGRIN EEHEDDFEAR SESSSGSMIT HSTEPKMQLN VEEYIQTMIA
RVSTENEITN TSNQTANIVI DPGSIDSEEI NKLAAKLVEE SILKASQEAA SDNHEKERSS
ATSKADYERS FDQDVTYERS SPLLEPSEEP VMESKEPELT QEEIDHIARI QSLAEQSSFE
QASTIPDRPP LPARLPTVDE PIVISEQHEE DRSSATSGAD YERSFDQEVT YERSSPLLEP
CEEPVMESKE PELTQEEIDH IARIQSLAEK SSFEQASTIP DRPPLPARLP TVDEPIVISE
QHEEDRSSAT SGADYERSFD QDVTYEKSSP LLEPSEDPVM ESKEPELTQE EIDHIARIQS
LAEKSSFEQT STIPDRPPLP ARLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE
RSSPLLEPCE EPVMESKEPE LTQEEIDNIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV
DEPIVSSEQQ EEDRSSATSG ADYERSFDQD VTYERSSPLL EPSEDPVMES KEPELTQEEI
DHIAWIQSIA EQSSFEQAST VPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS
FDQDVTYERS SPLLEPCEEP VMESKEPELT QEEIDHIAWI QSSAEQSSFE QASTVPDRPP
LPVRLPTVDE PIVSSEQHEE DRSSATSGAD YERSFDQDAT YERSSPLLEP CEEPVMESRV
PELTQEEIDH IARIQSLAEK SSFEQTSTIP DRPPLPARLP TVDEPIVSSE QHEEDRSSAT
SGADYERSSD QEVTYERSSP LLEPCEEPVM ESKEPELTQE EIDHIAWIQS IAEQSSFEQA
STVPDRPPLP VRLPTVDEPI VSSEQHEDDR SSATSGADYE RSFDQDVTYE RSSPLLEPCE
EPVMESKEPE LTQEEIDHIA WIQSIAEQSS FEQASTVPDR PPLPVRLPTV DEPIVSSEQH
EDDRSSATSG DDYERPFDQD FTYERSSPLL EPCEEPVMES RVPELTQEEI DHIAWIQSIA
EQSSFEQAST IPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS SDQEVTYERS
SPLLEPCEEP VMESKKPELT QEEIDHIAWI QSIAEQSSFE QASTIPDRPP LPVRLPTVDE
PIVSSEQHED DRSSATSGAD YERSFDQDVT YERSSPLLEP SEDPVMESKE PELTQEEIDH
IAWIQSIAEQ SSFEQASTIP DRPPLPVQLP TVDEPIVSSE QQEEDRSSAT SGADYERSFD
QDVTYERSSP LLEPSEDPVM ESKEPELTQE EIDHIAWIQS IAEQSSFEQA SKIPDRPPLP
VRLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE RSSPLLEPSE EPVMESRVPE
LTQEEIDHIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV DEPIVSSEQH EEDRSSATSG
ADYERSSDQE VTYERSSPLL EPCEEPVMES KEPELTQEEI DHIAWIQSIA EQSSFEQAST
IPDRPPLPVR LPTVDEPIVI SEQHEEDRSS ATSGADYERS FDQDVTYERS SPLLIPSEDP
VMESKESELT QEEIDHIARI QSLAEQSLFE QASTIPDRPP LPVRLPTVDE PIVISEQHEG
DRSSATSGAD YERSFDQDVM YERSSPLLIP SEDPVMESKE SELTQEEIDH IARIQSLAEQ
SSFEQASTIP DRPPLPVRLP TVDEPIVISE QHEGDRSSAT SGADYERSFD QDVTYERSSP
LLEPCDEPVM ESKEPELTQE EIDHIARIQN LAEQSSFEQA STITDRPPLP VRLPTVDEPI
VISEQHEGDR SSATPGADYE RSYDQDVTYE RSSPLLEPSE VPVMVSKAAV LTQEEIDHIA
IMQSLAETED RKALLEPCEE PVMESKKPEL TQEEIDHIAW IQSIAEQSSF EQASTIPDRP
PLPVRLPTVD EPIVSSEQHE DDRSSATSGA DYERSIDQEV TYERSSPLLE PCEEPVMESK
KPELTQEEID HIAWIQSIAE QSSFEQASTI PDRPPLPVRL PTVDEPIVSS EQHEEDRSSA
TSGADYERSS DQEVTYDRSS PLLEPCEEPV MESKPELTQE EIDHIAWIQS IAEQSSFEQA
STIPDRPPLP VRLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE RSSPLLEPSE
DPVMESKEPE LTQEEIDHIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV DEPIVSSEQH
EDDRSSATSG TDYERSFDQD VTYERSSPLL EPCEDPVMES KEPELTQEEI DHIAWIQSIA
EQSSFEQAST IPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS FDQDVTYERS
SPLLEPSEDP VMESKEPELT QEEIDHIARI QSLAEQSSFE QASTVPDRPP LPVRLPTVDE
PIVSSEQHED DRSSATSGAD YERPFDQDFT YERSSPLLEP CEEPVMESKK PELTQEEIDH
IAWIQSIAEQ SSFEQASTIP DRPPLPVRLP TVDEPIVSSE QHEEDRSSAT SGADYERSFD
QDVTYERSSP LLEPYEEPVM ESKVPELTQE EIDHIARIQS LAEQSSFEQA PTIPDRPPLP
VRLPTVDEPI VISEQHEGDR SSATSGADYE RSFDQDVTYE RSSPLLIPSE DPGNPSEPAP
TPEEIHHTAC DPSIAAPSSS FEQASTVPDR PPLPVRLPTV DEPIVSSEQH EDDRSSATSG
ADYERSFDQD VTYERSSPLL EPCEEPVMES KEPELTQEEI DHIAWIQSIA EQSSFEQAST
VPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS FDQDVTYERS SPLLEPCEEP
VMESKEPELT QEEIDHIAWI QSIAEQSSFE QASTIPDRPP LPVRLPTVDE PIVSSEQHED
DRSSATSGTD YERSFDQDVT YERSSPLLEP SEEPVMLSKE AELTQEEIDH IAIIQSLAEK
SSFEQFGIQT GHPFLPVRIL TERQNDHDRI SEEDNTSSCS SENNIILKYS DISYDRNTPL
LNSDDEFLEK DFGASAESSE PSQGNWAKFE EISSSSNAEW PTNISTYKFP SFSEKNVNED
LLNKSSWDCR DNVIVDDVIE EEDENDLLGD VTYSREVNKD YWKDSSTIPL VRIECVSDEQ
INVNEETPGI DKEIKSAEIS KDDNSVVSCS SENQIDHTND EHFDFGQEDS EHEELKHCSS
QYSFDSSLPP FHRYVACPSI TPSEGDDGGS SETGHPTTDE CYNEDVNRQI EQYSALASLS
KSVLPVVEIK IDEATSESSV LQLDDDDKSI SEQEDFIDNM DLTLKRNEDK TNITNLGASE
IQQQEENEIS AQTAEVESSD SWNSKTVKML SDDSAFAEET QHVDLVSTSA TKHEDYAEEQ
TLSQEEIDHI ARITAMATED NTDLQTLPTP QVRQNEPELS QKEIDHITRI AAMANKDFGM
YPSIVSEHPA PVESELTQEE LDHIARITEI ASMDISTLPP PTGKPSETSL TQEELDHIAR
IAEMASAEYD VPVKIFEPPE LTQEELDHIA KITAMAAQDV QLPATQRSIT HKVSLTPPPP
PPSKHFEQDL TQEELDHIAR IAEMADMDYN TPFTAEPVQD EEEEPITESG SDATSGADIF
DEQEDASSDR EKRSGTSFPD NAETSLEDDT AHEKSYPQLE PSEEPVMKSK EPELTQEEID
HFARIQSLAE QSSFEQASTI PDRQPLPVRL PTVDEPIVIS EQHEGDRSSA TSGADYERSF
DQDVTYERSS PLLEPCDEPV MESKEPELTQ EEIDHIARIQ SLAEQSSFEQ TSTIPDRQPL
PVRHPTVDEP IVISGQHEED RSSATSGADY QQSFDQDDPS KRSSPLLEPN EEQMMESTQP
ELTQDHSSTT ISDILIKEVD KFIPEAKFGR SFEEHDGRLI HSGNLDIDVP LESDCRKTFG
QDKSESTMPT ELTEADLERV ARIHQHFDQS SFDEVVVPTS HPDDGRSSSV RSSEYLDTVT
PLSSCAATPI LTNPKLVQEE LDHIAFIQKM AEQFTFDEVE TPILRQNTTS HSVSYNFVQR
SCHEDVSFQK KESPALTSLK EIAESSQLTQ EELDHIASIQ QMADQPYFEE SHFIFKSDVK
EEKKEDKLHH ELFVEECVAQ ESITQDDVER KPLELTQEEI DHIAKIQKLA DQSSFEQASA
IQSLPTAEEP IVEKREDDKS NITSGADYQQ SFDQDVTYKR SSPLLEPSEE PVMESKEPEL
TQEEIDHIAR IQSLAEQSSF EQASTIPDRP PLPVRLPTVD EPIVISEQHE GDISSATSGA
DYERSLDQDV TYERSSPLLE PCDEPVMESK EPELTQEEID HIARIQSLAE QSSFEQASTI
PDRPPLPVRL PTVDEPIVSS EQHEEDRSSA TSGADIERSF DIDVSQDRVS PISEHEEGVT
QEEMEHIARI AAMAAEDFKH PEGNLEPEFS QPDKDHIAMM KKLEEQSKME NQELPANPII
HTDQVDRQES EGSSSATSGA DIPSSFDISS PIPPEPLQDH ITTSQKLISR PSIEISNVPS
RLPELSLTAV QRGSEDISSA TSGAGIERSF DGISPLPNFS EEPIMINDEM NYVLMVTHMA
QKIDVQQPIQ ETSTLRKAVL CESPEDFSEA TSGADTESIS ETTANKKDSN DSNGLTEEEM
KHIAEVLRKA EASSAASGMF ERDSNLPPLR RTSITYTSHF SPSVIRDLRS STSFTSVPAA
SDEEEIVKGK LKREPSTQVV YTDHFLRDLQ SINAYLEKGE DGTDVTIEET SHDNESSSLP
EEDEHITDVY HFDVGTSLLV QQYILQQSTF QEAAGLHISP IRRTMSAACT AEKHIDDEEN
IKEREVKHAQ SHDQIKKRAG GEPNAYELLE QHSFRHTQPL LCNVDFLWRL NFAANRMTEE
IADEAGRELR AHYRNVANPR ARYFSDAYDI GTDDEEEEVT ETSQAGFSVE PMRHEEQSYG
LFSFFTSSKR SVSDRPRSAL AMFTNPSPSA SPSLLRKESE DRGDILNLLR RSSGADSRAS
NDSSASRLPD TALVGLSEAE KQHIMSVMSR SNRNTSPMTS RRCSSALQML PEVDNLSEAE
KEHIQTILEK AESKTPFMIK VPMKKQISSR TESTNSRVSS EGIDEEVENE VQRKKTIEEP
IVEIPSRAVT PRNNLRVIPP PIAISHPTPP HSAKTDTGSR HSSGSSAHSQ FGFSTPSISG
FKIFFDKAKT ATETLVKEIK DEVIVEVDKD KTETKPEPNV SNELTAEEFE HIRRINEMAG
IDEPIQPPPI AQERRKSSVV SGLKNMFGVG KHDESELTTE EKEHIRQMSL MAEKMDEEIL
DEQSKPKSTF GLKNFFGKAT QSVMHATDSV IKNVQNQSKQ SLSGLTQEEL DNIAQATESA
QQESKQELTQ DEIDHIARIN AMAAEDFEQP AVNMNQGLSQ AEKDHIARIE AMAADDSQSK
IIVPPPSIIQ KDIELSMEEM DHIARIAAMA DEDFTHPVKG AVAPIYDENY SRDDGAIDRF
PASTATPVFA QPSEIELSEE EREHISRIAA MAEEDFNTPY VSTHPTQQIE IELTEEEKEH
IARIEAMASE DLNAPSPFIQ QEQRVATMPV PINYHVEEPT LSQEEIDHIA RITAMATEDN
TDLQTLPTPQ VKQNEPELSQ EEIDHITRIA AMANEDFGMY PSIVSEHPAP VESELTQEEL
DHIAKITGMA SMDISTLPPP TGKPSETSLT QEELDHIARI AEMASAEYDV PVKIFEPPEL
TQEELDHIAK ITAMAAQDVQ LPATQRSITH KVSLTPPPPP PSKHFEQDLT QEELDHIARI
AEMADMDYNT PFTAEPVQDE EEEPITESGS DATSGADIFD EQEDASSGAS GSFDNNNAQV
LTSGFSPDRV TSPAALDTTE EPQGPIMAQK TVSPTPSADS MASRKSSEYD IRSISEIRQE
SESDIGKWYE EQLSFMRQSI HDEEEDVGHE IRTDVEEFPL EYVEDQLHFL EGIDVESQHH
EPTTSSAFFG TGRSIGEGEK RKYGDDAVEQ QKLENYEEEE KTKSSSREAF DDGFETQREE
SLRAQQTPID SLPGSRMLKR PNFGFLSNIA NDAINKAKEA GSQIQAAVPI KPSSSSSNIV
NNNVFSSSKS STSLGTSAPT KSIPSPQIGI PMDGLSEEER RQIMSVMAAA DFDDSVNNVK
PSTSGSSNIP AGMEDLSEAE REKIMSVMAN AEMEMGARFP PPSSQIPTRS PSVMSSSIMS
ELPPGLDDLS DDERMKIMAV MAEADMQNVR KPIARGPPPM PPSTSMIPPG MEGLSEEERQ
KIMSVMANAE TDSSSSVITS RQPSRSPSVA RMQPQLMPPQ QAIPIIPPGL EGLSDEERHT
IMSVMAEAEF EESRSQVPSR QPSRSPSFVN PQQSFHPIPS FEPIVPPGLE DLSEEERQKI
MSVMMNAEVE ESRSQLPSRQ PSRSPSVAMI QAPAVPIIPS GMEDLPEAER QKIMSVMAEA
EIQNFVPSRS PSNYSMQPVP VIPHGLEDLS EAERQKILSV MAEAEIDSAK IPSRSTSSYS
MPPPLPQMSQ PEITTGLEHS SEADMEFGRD SSRSHQVIPP GLENLSEEER QQIMSVMAHA
ELESIIPSGH IDQPISLPRG HTGFKPAGIV NEDELFETER KQREESPTRE SGYATSTSYE
RELAMGDEER MDGLLEDIIR IREGARSRRD SRDEVLHRRE EDPEVHTPEE SSTAVVTDVP
SVSPVTENVP EKQTDDFDFT YSDSRFAEIV QMQEEEEAGS LQKQKVDEKP RMWETVFDGD
ESELPHQDFV FNEPTTKKTS DFDFPKETDE VFEKPSEIQR IRVTKNHDVD MDEIYDNVIA
TEAPSSVSQR RQPVDSETSV KSRTIQRGPT KPPPMIKITV EEETKSDSDE ESCSEDDEEY
PDRVVAAPTA PAPTFEEVEN ERIRQEELGK EVLQQIMAFG EVANDEFDVQ WAKTTTSQTP
STSTKPTVTA PKRSDPIPIA PSQRSKEIEE ERIRTEALEE EEFYRHGHNP FLESPEEDEV
SINMEDVEYA EIARLYESAN QTMRRPGPVY TITEDESEDD GTLSNSESRL VAREKRLMDK
KTADSLMAKY QKMKKVQAKQ TTTASSTSVT ATPAYAIINF SDLKTSTRTT DSNSYFETTK
NIPALEIKDP KKDIPPEISA SIDKTMAEVD ALLGQVYTNE KAIPNLLCFD QSNFSNHPPT
SSASTSTADD LILLKNNNSS SPSFLLPLQS SVLGSQLDSV RDDNERNENE TTSPRGLKRS
PGMLLPSPTS TSIFPMPPTA AESVGAAIGA TTASMFGGIS VADPPPTMDG LTNSYKWLQN
IEDDGNLANN DMGRRKLPSI PPNSSAFPPP TSVTTNVIST DTSMPSTSSG PAPTYVDDYN
VTLPSDPIVA ESLLKGGSLT RRHQHQQQHQ APVYITSSAS RPPSAAGSNI FQESRPTSSL
SMYQNDVILS RPGSAASNYT TASTINPTIL AGASYSSKAS SHIRQPVSVR SPRAQTGTTQ
TTAASGSASN SIRPSIGSSS VTTRVPNTLA RVLLKKELKD VLIQRKQRLE ATEIEANQRH
YKVQKMLITG LLPEKPEDDI PNIVKCDLPA DLVRGVHISM QPPSPAVSAF SPRRYHHPTS
VASHQSHPST FKHMSKSIAC QADELPPVKP MISLRTQLDM ERRPQLMTYV GKRSAETQTE
LANYESITPT VRYGSIPRSS RERTASRRYR EQQQQIYNQM PQNHNDLLEI TKKYFEDYDR
QLREFGERAR RHSRRRFDFH DDDDQDDMRK NQVMHELARR KERMCASCEI LSTTDPIRTA
LNPNVPMSSD YSSHVPHYGS LPRIDYPRGT RSDVRDFTYR QQHLPQQPPT NYSYNYGSLP
RNFERGFSDL PPIEIENEQS FGAPPRHRSN LGYESTSMFN LSDPVYLGYD SIPMVQHQQP
RVYDQIPSGY AQDTTNLNSL NQGVRGSDMV SQYASYLNSQ FQSGLQQSAQ LPQPMIPITR
YDAPMSDPYV SSRSRLVDQM NQGYNSNQYH HHSTLLAPKS AQMTHIAPTY NQLAQQQGIP
MQNTQMDPLM MSSGRIPSSS SQVYSRNEMN YGSRPAQSSL FEYGNRRQYG AAPPPTYDVP
NVSSASDWRT TQQQGLIQQM PMQMQQQQHN TFDARWPKED ALSRMYATAS RRRAQETALT
SSNKISTGSR SYARRPIRPS SYRNPEATNS MPDRHVARRT AENSRYDVKR ILLTRSYKHH
NIYNDLGVRV VGGKRQMNGE LSAYVSQLHS TANNQTLGQI KIGDEVVEWN GILLRGKTFE
EVERIVNKSH GEIEMVIRTY KNPSSGVYDT LPLNRNTMRD DLSPDRVPPV PMHRINGINN
NSVLHHHTLS DSSCHGHIQV SLGYDGNSRL VAKIIRARGL KSRDQSRSAP NPFVKVYLLP
GRKVSHKRRT RFVDSSCAPE WNQVLEYQVA PHTLNTMFLE FTVCDYQRDV DDLPLGNVQI
PLADKSAINT GPRWYPLQGS YDQPIPQHYM NGTSLSQIPS IAAASKHSAA VHNHHNHNYS
EVPPSILYPK GGVGTRHPDK PVRHATFNYN PVSLDIGYPA IN
