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CLA1_CAEEL
ID   CLA1_CAEEL              Reviewed;        8922 AA.
AC   W6RTA4; H2KYL0; Q9BI65; W6RT96; W6SB84; W6SB91;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   11-NOV-2015, sequence version 2.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein clarinet {ECO:0000303|PubMed:29160205};
GN   Name=cla-1 {ECO:0000303|PubMed:29160205, ECO:0000312|WormBase:F45E4.3a};
GN   Synonyms=tag-80 {ECO:0000312|WormBase:F45E4.3a};
GN   ORFNames=F45E4.3 {ECO:0000312|WormBase:F45E4.3a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND MUTAGENESIS OF 6751-PRO--GLY-8892.
RX   PubMed=29160205; DOI=10.7554/elife.29276;
RA   Xuan Z., Manning L., Nelson J., Richmond J.E., Colon-Ramos D.A., Shen K.,
RA   Kurshan P.T.;
RT   "Clarinet (CLA-1), a novel active zone protein required for synaptic
RT   vesicle clustering and release.";
RL   Elife 6:0-0(2017).
CC   -!- FUNCTION: Required for synapse development in the active zone of
CC       presynaptic terminals of specific neurons including serotonergic NSM
CC       neurons (PubMed:29160205). The active zone is a protein-dense neuronal
CC       region within the presynaptic bouton, from which synaptic vesicles send
CC       neurotransmitter signals across the synapse (PubMed:29160205). Plays a
CC       role in the recruitment and clustering of synaptic vesicles in the
CC       active zone of presynaptic terminals in serotonergic NSM neurons, and
CC       coordinates the release of synaptic vesicles at presynaptic terminals
CC       to regulate neurotransmission at neuromuscular junctions
CC       (PubMed:29160205). Regulates synapse number in inhibitory motor neurons
CC       and plays a role in spontaneous postsynaptic synaptic vesicle release
CC       in muscle cells (PubMed:29160205). {ECO:0000269|PubMed:29160205}.
CC   -!- INTERACTION:
CC       W6RTA4; Q19980: cat-4; NbExp=2; IntAct=EBI-2916517, EBI-311852;
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:29160205}. Cell
CC       projection, axon {ECO:0000269|PubMed:29160205}. Note=Localization at
CC       the synapse may depend on other active zone proteins such as syd-1 and
CC       syd-2 (PubMed:29160205). Anchored via the C-terminus to the active
CC       zone, a protein-dense region within the presynaptic bouton, of the
CC       synaptic compartment (PubMed:29160205). The N-terminus extends away
CC       from the active zone (PubMed:29160205). {ECO:0000269|PubMed:29160205}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage, Alternative splicing; Named isoforms=6;
CC       Name=a {ECO:0000312|WormBase:F45E4.3a};
CC         IsoId=W6RTA4-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:F45E4.3b};
CC         IsoId=W6RTA4-2; Sequence=VSP_059922, VSP_059923;
CC       Name=c {ECO:0000312|WormBase:F45E4.3c};
CC         IsoId=W6RTA4-3; Sequence=VSP_059921, VSP_059922, VSP_059923;
CC       Name=d {ECO:0000312|WormBase:F45E4.3d};
CC         IsoId=W6RTA4-4; Sequence=VSP_059921;
CC       Name=e {ECO:0000312|WormBase:F45E4.3e};
CC         IsoId=W6RTA4-5; Sequence=VSP_059920;
CC       Name=f {ECO:0000312|WormBase:F45E4.3f};
CC         IsoId=W6RTA4-6; Sequence=VSP_059920, VSP_059922, VSP_059923;
CC   -!- TISSUE SPECIFICITY: Expressed in the nervous system.
CC       {ECO:0000269|PubMed:29160205}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the nervous system from the three-
CC       fold stage of embryonic development. {ECO:0000269|PubMed:29160205}.
CC   -!- MISCELLANEOUS: [Isoform b]: Produced by alternative splicing.
CC       {ECO:0000269|PubMed:29160205}.
CC   -!- MISCELLANEOUS: [Isoform c]: Produced by alternative promoter usage and
CC       alternative splicing. {ECO:0000269|PubMed:29160205}.
CC   -!- MISCELLANEOUS: [Isoform d]: Produced by alternative promoter usage.
CC       {ECO:0000269|PubMed:29160205}.
CC   -!- MISCELLANEOUS: [Isoform e]: Produced by alternative promoter usage.
CC       {ECO:0000269|PubMed:29160205}.
CC   -!- MISCELLANEOUS: [Isoform f]: Produced by alternative promoter usage and
CC       alternative splicing. {ECO:0000269|PubMed:29160205}.
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DR   EMBL; BX284604; CCD63778.1; -; Genomic_DNA.
DR   EMBL; BX284604; CCD63779.1; -; Genomic_DNA.
DR   EMBL; BX284604; CDM63472.1; -; Genomic_DNA.
DR   EMBL; BX284604; CDM63473.1; -; Genomic_DNA.
DR   EMBL; BX284604; CDM63478.2; -; Genomic_DNA.
DR   EMBL; BX284604; CDM63477.2; -; Genomic_DNA.
DR   RefSeq; NP_001294143.1; NM_001307214.1. [W6RTA4-3]
DR   RefSeq; NP_001294144.1; NM_001307215.1. [W6RTA4-4]
DR   RefSeq; NP_001294148.2; NM_001307219.2. [W6RTA4-1]
DR   RefSeq; NP_001294149.2; NM_001307220.2. [W6RTA4-2]
DR   RefSeq; NP_501237.1; NM_068836.3.
DR   RefSeq; NP_501238.1; NM_068837.3.
DR   SMR; W6RTA4; -.
DR   IntAct; W6RTA4; 10.
DR   STRING; 6239.F45E4.3a.1; -.
DR   EPD; W6RTA4; -.
DR   PaxDb; W6RTA4; -.
DR   PeptideAtlas; W6RTA4; -.
DR   EnsemblMetazoa; F45E4.3a.1; F45E4.3a.1; WBGene00018468. [W6RTA4-1]
DR   EnsemblMetazoa; F45E4.3b.1; F45E4.3b.1; WBGene00018468. [W6RTA4-2]
DR   EnsemblMetazoa; F45E4.3c.1; F45E4.3c.1; WBGene00018468. [W6RTA4-3]
DR   EnsemblMetazoa; F45E4.3d.1; F45E4.3d.1; WBGene00018468. [W6RTA4-4]
DR   EnsemblMetazoa; F45E4.3e.1; F45E4.3e.1; WBGene00018468. [W6RTA4-5]
DR   EnsemblMetazoa; F45E4.3f.1; F45E4.3f.1; WBGene00018468. [W6RTA4-6]
DR   GeneID; 177539; -.
DR   KEGG; cel:CELE_F45E4.3; -.
DR   UCSC; F45E4.3b.1; c. elegans.
DR   CTD; 177539; -.
DR   WormBase; F45E4.3a; CE51009; WBGene00018468; cla-1. [W6RTA4-1]
DR   WormBase; F45E4.3b; CE51026; WBGene00018468; cla-1. [W6RTA4-2]
DR   WormBase; F45E4.3c; CE49484; WBGene00018468; cla-1. [W6RTA4-3]
DR   WormBase; F45E4.3d; CE49489; WBGene00018468; cla-1. [W6RTA4-4]
DR   WormBase; F45E4.3e; CE24980; WBGene00018468; cla-1. [W6RTA4-5]
DR   WormBase; F45E4.3f; CE24981; WBGene00018468; cla-1. [W6RTA4-6]
DR   eggNOG; KOG1181; Eukaryota.
DR   eggNOG; KOG2060; Eukaryota.
DR   GeneTree; ENSGT00620000087961; -.
DR   HOGENOM; CLU_222840_0_0_1; -.
DR   OMA; TAVWMLY; -.
DR   OrthoDB; 15051at2759; -.
DR   PRO; PR:W6RTA4; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00018468; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0031045; C:dense core granule; IBA:GO_Central.
DR   GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0048786; C:presynaptic active zone; IDA:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR   GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR   GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR   GO; GO:0017156; P:calcium-ion regulated exocytosis; IBA:GO_Central.
DR   GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR   GO; GO:0048790; P:maintenance of presynaptic active zone structure; IMP:UniProtKB.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
DR   GO; GO:0098814; P:spontaneous synaptic transmission; IMP:UniProtKB.
DR   GO; GO:0097091; P:synaptic vesicle clustering; IMP:UniProtKB.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR   GO; GO:0016079; P:synaptic vesicle exocytosis; IMP:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   1: Evidence at protein level;
KW   Alternative promoter usage; Alternative splicing; Cell projection;
KW   Coiled coil; Reference proteome; Synapse.
FT   CHAIN           1..8922
FT                   /note="Protein clarinet"
FT                   /id="PRO_0000445624"
FT   DOMAIN          8570..8661
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          8714..8835
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          11..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          687..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          971..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1062..1139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1151..1331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1347..1420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1444..1520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1538..1619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1632..1710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1726..1801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1820..1898
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1939..1992
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2032..2084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2126..2175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2194..2213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2220..2246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2329..2403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2423..2497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2516..2594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2610..2684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2704..2845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2892..2963
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2983..3155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3171..3249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3268..3337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3619..3639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3995..4079
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4117..4169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4181..4271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4557..4624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4636..4656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4666..4685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4730..4801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4855..4899
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5004..5036
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5360..5379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5390..5413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5484..5511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5540..5572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6194..6303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6354..6437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6487..6510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6577..6609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6668..6691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6728..6768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6998..7018
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7045..7098
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7137..7175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7202..7263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7313..7350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7598..7623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7760..7797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7842..7881
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8510..8562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          385..405
FT                   /evidence="ECO:0000255"
FT   COILED          7895..7915
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        529..555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..637
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..731
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..778
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..825
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        910..925
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        999..1013
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1093..1107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1187..1201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1227..1241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1281..1295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1375..1401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1469..1483
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1563..1577
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1603..1617
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1654..1677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1751..1765
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1845..1859
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1939..1953
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2133..2147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2354..2368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2448..2462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2541..2555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2635..2649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2729..2743
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2769..2789
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2823..2837
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2917..2931
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3017..3031
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3105..3119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3199..3213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3293..3307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4023..4037
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4045..4079
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4124..4138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4181..4197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4218..4240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4246..4271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4583..4598
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4610..4624
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4670..4684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4758..4772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4780..4801
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4869..4885
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5009..5030
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5360..5374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5393..5410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5550..5572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6225..6284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6285..6303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6375..6419
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6487..6504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6735..6757
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7045..7068
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7070..7090
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7159..7175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7202..7226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7313..7330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7599..7613
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8513..8534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..7691
FT                   /note="Missing (in isoform e and isoform f)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059920"
FT   VAR_SEQ         1..6280
FT                   /note="Missing (in isoform c and isoform d)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059921"
FT   VAR_SEQ         8516..8527
FT                   /note="ETALTSSNKIST -> GDNSPSFLIDGR (in isoform b, isoform
FT                   c and isoform f)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059922"
FT   VAR_SEQ         8528..8922
FT                   /note="Missing (in isoform b, isoform c and isoform f)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059923"
FT   MUTAGEN         6751..8892
FT                   /note="Missing: In wy1048; defective morphology of the
FT                   active zone region of the synapse, and abnormal clustering
FT                   and localization of synaptic vesicles at presynaptic
FT                   terminals of serotonergic NSM neurons. Defective synaptic
FT                   transmission at neuromuscular junctions with increased
FT                   sensitivity to the acetylcholinesterase inhibitor Aldicarb,
FT                   and a 46% reduction in the frequency of spontaneous
FT                   postsynaptic currents in postsynaptic muscle cells."
FT                   /evidence="ECO:0000269|PubMed:29160205"
SQ   SEQUENCE   8922 AA;  1000209 MW;  6874549BD09F2F54 CRC64;
     MSSWFSYFGF SKGPPLEEVR EESEEDAQVP EQVVSKNTEE EIADAINRLS PEQQNLIQDV
     LRRAESSRKE AKVVVDAEMM RSRFRQRDSI EDSQEIDHRY SLIQMDSIPE NMVTNEMEER
     LATTQNEDII PESSQRSPIT PRKIHEKRAS ITEVTTENLR HRFQKMKSHL TTWFNSLDYD
     GEYIFDFTSK PEKSEKLGEL TMQYIDALSQ AIMISSHIEY SHHVLSSNPK FQQMCTQFCE
     SIFSVAFDEL TYQLLDDKVQ ETLNEYCGQI AEEALQAAFF TMISKTLSKS KECEQVLNEI
     SSMHKSRSFE SAKQLDQLLS RIEDDRESSR KSSPYLYEVL GKSSDSPSTS ASVEYRSQNS
     YESEISFETP DIHVEELFDT HLNEKDETKL ILKSVEDKLE TTEIEGNVPK IDENLIENIQ
     YDSGDQEHYI WISGPLGRIN EEHEDDFEAR SESSSGSMIT HSTEPKMQLN VEEYIQTMIA
     RVSTENEITN TSNQTANIVI DPGSIDSEEI NKLAAKLVEE SILKASQEAA SDNHEKERSS
     ATSKADYERS FDQDVTYERS SPLLEPSEEP VMESKEPELT QEEIDHIARI QSLAEQSSFE
     QASTIPDRPP LPARLPTVDE PIVISEQHEE DRSSATSGAD YERSFDQEVT YERSSPLLEP
     CEEPVMESKE PELTQEEIDH IARIQSLAEK SSFEQASTIP DRPPLPARLP TVDEPIVISE
     QHEEDRSSAT SGADYERSFD QDVTYEKSSP LLEPSEDPVM ESKEPELTQE EIDHIARIQS
     LAEKSSFEQT STIPDRPPLP ARLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE
     RSSPLLEPCE EPVMESKEPE LTQEEIDNIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV
     DEPIVSSEQQ EEDRSSATSG ADYERSFDQD VTYERSSPLL EPSEDPVMES KEPELTQEEI
     DHIAWIQSIA EQSSFEQAST VPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS
     FDQDVTYERS SPLLEPCEEP VMESKEPELT QEEIDHIAWI QSSAEQSSFE QASTVPDRPP
     LPVRLPTVDE PIVSSEQHEE DRSSATSGAD YERSFDQDAT YERSSPLLEP CEEPVMESRV
     PELTQEEIDH IARIQSLAEK SSFEQTSTIP DRPPLPARLP TVDEPIVSSE QHEEDRSSAT
     SGADYERSSD QEVTYERSSP LLEPCEEPVM ESKEPELTQE EIDHIAWIQS IAEQSSFEQA
     STVPDRPPLP VRLPTVDEPI VSSEQHEDDR SSATSGADYE RSFDQDVTYE RSSPLLEPCE
     EPVMESKEPE LTQEEIDHIA WIQSIAEQSS FEQASTVPDR PPLPVRLPTV DEPIVSSEQH
     EDDRSSATSG DDYERPFDQD FTYERSSPLL EPCEEPVMES RVPELTQEEI DHIAWIQSIA
     EQSSFEQAST IPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS SDQEVTYERS
     SPLLEPCEEP VMESKKPELT QEEIDHIAWI QSIAEQSSFE QASTIPDRPP LPVRLPTVDE
     PIVSSEQHED DRSSATSGAD YERSFDQDVT YERSSPLLEP SEDPVMESKE PELTQEEIDH
     IAWIQSIAEQ SSFEQASTIP DRPPLPVQLP TVDEPIVSSE QQEEDRSSAT SGADYERSFD
     QDVTYERSSP LLEPSEDPVM ESKEPELTQE EIDHIAWIQS IAEQSSFEQA SKIPDRPPLP
     VRLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE RSSPLLEPSE EPVMESRVPE
     LTQEEIDHIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV DEPIVSSEQH EEDRSSATSG
     ADYERSSDQE VTYERSSPLL EPCEEPVMES KEPELTQEEI DHIAWIQSIA EQSSFEQAST
     IPDRPPLPVR LPTVDEPIVI SEQHEEDRSS ATSGADYERS FDQDVTYERS SPLLIPSEDP
     VMESKESELT QEEIDHIARI QSLAEQSLFE QASTIPDRPP LPVRLPTVDE PIVISEQHEG
     DRSSATSGAD YERSFDQDVM YERSSPLLIP SEDPVMESKE SELTQEEIDH IARIQSLAEQ
     SSFEQASTIP DRPPLPVRLP TVDEPIVISE QHEGDRSSAT SGADYERSFD QDVTYERSSP
     LLEPCDEPVM ESKEPELTQE EIDHIARIQN LAEQSSFEQA STITDRPPLP VRLPTVDEPI
     VISEQHEGDR SSATPGADYE RSYDQDVTYE RSSPLLEPSE VPVMVSKAAV LTQEEIDHIA
     IMQSLAETED RKALLEPCEE PVMESKKPEL TQEEIDHIAW IQSIAEQSSF EQASTIPDRP
     PLPVRLPTVD EPIVSSEQHE DDRSSATSGA DYERSIDQEV TYERSSPLLE PCEEPVMESK
     KPELTQEEID HIAWIQSIAE QSSFEQASTI PDRPPLPVRL PTVDEPIVSS EQHEEDRSSA
     TSGADYERSS DQEVTYDRSS PLLEPCEEPV MESKPELTQE EIDHIAWIQS IAEQSSFEQA
     STIPDRPPLP VRLPTVDEPI VSSEQHEEDR SSATSGADYE RSFDQDVTYE RSSPLLEPSE
     DPVMESKEPE LTQEEIDHIA WIQSIAEQSS FEQASTIPDR PPLPVRLPTV DEPIVSSEQH
     EDDRSSATSG TDYERSFDQD VTYERSSPLL EPCEDPVMES KEPELTQEEI DHIAWIQSIA
     EQSSFEQAST IPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS FDQDVTYERS
     SPLLEPSEDP VMESKEPELT QEEIDHIARI QSLAEQSSFE QASTVPDRPP LPVRLPTVDE
     PIVSSEQHED DRSSATSGAD YERPFDQDFT YERSSPLLEP CEEPVMESKK PELTQEEIDH
     IAWIQSIAEQ SSFEQASTIP DRPPLPVRLP TVDEPIVSSE QHEEDRSSAT SGADYERSFD
     QDVTYERSSP LLEPYEEPVM ESKVPELTQE EIDHIARIQS LAEQSSFEQA PTIPDRPPLP
     VRLPTVDEPI VISEQHEGDR SSATSGADYE RSFDQDVTYE RSSPLLIPSE DPGNPSEPAP
     TPEEIHHTAC DPSIAAPSSS FEQASTVPDR PPLPVRLPTV DEPIVSSEQH EDDRSSATSG
     ADYERSFDQD VTYERSSPLL EPCEEPVMES KEPELTQEEI DHIAWIQSIA EQSSFEQAST
     VPDRPPLPVR LPTVDEPIVS SEQHEDDRSS ATSGADYERS FDQDVTYERS SPLLEPCEEP
     VMESKEPELT QEEIDHIAWI QSIAEQSSFE QASTIPDRPP LPVRLPTVDE PIVSSEQHED
     DRSSATSGTD YERSFDQDVT YERSSPLLEP SEEPVMLSKE AELTQEEIDH IAIIQSLAEK
     SSFEQFGIQT GHPFLPVRIL TERQNDHDRI SEEDNTSSCS SENNIILKYS DISYDRNTPL
     LNSDDEFLEK DFGASAESSE PSQGNWAKFE EISSSSNAEW PTNISTYKFP SFSEKNVNED
     LLNKSSWDCR DNVIVDDVIE EEDENDLLGD VTYSREVNKD YWKDSSTIPL VRIECVSDEQ
     INVNEETPGI DKEIKSAEIS KDDNSVVSCS SENQIDHTND EHFDFGQEDS EHEELKHCSS
     QYSFDSSLPP FHRYVACPSI TPSEGDDGGS SETGHPTTDE CYNEDVNRQI EQYSALASLS
     KSVLPVVEIK IDEATSESSV LQLDDDDKSI SEQEDFIDNM DLTLKRNEDK TNITNLGASE
     IQQQEENEIS AQTAEVESSD SWNSKTVKML SDDSAFAEET QHVDLVSTSA TKHEDYAEEQ
     TLSQEEIDHI ARITAMATED NTDLQTLPTP QVRQNEPELS QKEIDHITRI AAMANKDFGM
     YPSIVSEHPA PVESELTQEE LDHIARITEI ASMDISTLPP PTGKPSETSL TQEELDHIAR
     IAEMASAEYD VPVKIFEPPE LTQEELDHIA KITAMAAQDV QLPATQRSIT HKVSLTPPPP
     PPSKHFEQDL TQEELDHIAR IAEMADMDYN TPFTAEPVQD EEEEPITESG SDATSGADIF
     DEQEDASSDR EKRSGTSFPD NAETSLEDDT AHEKSYPQLE PSEEPVMKSK EPELTQEEID
     HFARIQSLAE QSSFEQASTI PDRQPLPVRL PTVDEPIVIS EQHEGDRSSA TSGADYERSF
     DQDVTYERSS PLLEPCDEPV MESKEPELTQ EEIDHIARIQ SLAEQSSFEQ TSTIPDRQPL
     PVRHPTVDEP IVISGQHEED RSSATSGADY QQSFDQDDPS KRSSPLLEPN EEQMMESTQP
     ELTQDHSSTT ISDILIKEVD KFIPEAKFGR SFEEHDGRLI HSGNLDIDVP LESDCRKTFG
     QDKSESTMPT ELTEADLERV ARIHQHFDQS SFDEVVVPTS HPDDGRSSSV RSSEYLDTVT
     PLSSCAATPI LTNPKLVQEE LDHIAFIQKM AEQFTFDEVE TPILRQNTTS HSVSYNFVQR
     SCHEDVSFQK KESPALTSLK EIAESSQLTQ EELDHIASIQ QMADQPYFEE SHFIFKSDVK
     EEKKEDKLHH ELFVEECVAQ ESITQDDVER KPLELTQEEI DHIAKIQKLA DQSSFEQASA
     IQSLPTAEEP IVEKREDDKS NITSGADYQQ SFDQDVTYKR SSPLLEPSEE PVMESKEPEL
     TQEEIDHIAR IQSLAEQSSF EQASTIPDRP PLPVRLPTVD EPIVISEQHE GDISSATSGA
     DYERSLDQDV TYERSSPLLE PCDEPVMESK EPELTQEEID HIARIQSLAE QSSFEQASTI
     PDRPPLPVRL PTVDEPIVSS EQHEEDRSSA TSGADIERSF DIDVSQDRVS PISEHEEGVT
     QEEMEHIARI AAMAAEDFKH PEGNLEPEFS QPDKDHIAMM KKLEEQSKME NQELPANPII
     HTDQVDRQES EGSSSATSGA DIPSSFDISS PIPPEPLQDH ITTSQKLISR PSIEISNVPS
     RLPELSLTAV QRGSEDISSA TSGAGIERSF DGISPLPNFS EEPIMINDEM NYVLMVTHMA
     QKIDVQQPIQ ETSTLRKAVL CESPEDFSEA TSGADTESIS ETTANKKDSN DSNGLTEEEM
     KHIAEVLRKA EASSAASGMF ERDSNLPPLR RTSITYTSHF SPSVIRDLRS STSFTSVPAA
     SDEEEIVKGK LKREPSTQVV YTDHFLRDLQ SINAYLEKGE DGTDVTIEET SHDNESSSLP
     EEDEHITDVY HFDVGTSLLV QQYILQQSTF QEAAGLHISP IRRTMSAACT AEKHIDDEEN
     IKEREVKHAQ SHDQIKKRAG GEPNAYELLE QHSFRHTQPL LCNVDFLWRL NFAANRMTEE
     IADEAGRELR AHYRNVANPR ARYFSDAYDI GTDDEEEEVT ETSQAGFSVE PMRHEEQSYG
     LFSFFTSSKR SVSDRPRSAL AMFTNPSPSA SPSLLRKESE DRGDILNLLR RSSGADSRAS
     NDSSASRLPD TALVGLSEAE KQHIMSVMSR SNRNTSPMTS RRCSSALQML PEVDNLSEAE
     KEHIQTILEK AESKTPFMIK VPMKKQISSR TESTNSRVSS EGIDEEVENE VQRKKTIEEP
     IVEIPSRAVT PRNNLRVIPP PIAISHPTPP HSAKTDTGSR HSSGSSAHSQ FGFSTPSISG
     FKIFFDKAKT ATETLVKEIK DEVIVEVDKD KTETKPEPNV SNELTAEEFE HIRRINEMAG
     IDEPIQPPPI AQERRKSSVV SGLKNMFGVG KHDESELTTE EKEHIRQMSL MAEKMDEEIL
     DEQSKPKSTF GLKNFFGKAT QSVMHATDSV IKNVQNQSKQ SLSGLTQEEL DNIAQATESA
     QQESKQELTQ DEIDHIARIN AMAAEDFEQP AVNMNQGLSQ AEKDHIARIE AMAADDSQSK
     IIVPPPSIIQ KDIELSMEEM DHIARIAAMA DEDFTHPVKG AVAPIYDENY SRDDGAIDRF
     PASTATPVFA QPSEIELSEE EREHISRIAA MAEEDFNTPY VSTHPTQQIE IELTEEEKEH
     IARIEAMASE DLNAPSPFIQ QEQRVATMPV PINYHVEEPT LSQEEIDHIA RITAMATEDN
     TDLQTLPTPQ VKQNEPELSQ EEIDHITRIA AMANEDFGMY PSIVSEHPAP VESELTQEEL
     DHIAKITGMA SMDISTLPPP TGKPSETSLT QEELDHIARI AEMASAEYDV PVKIFEPPEL
     TQEELDHIAK ITAMAAQDVQ LPATQRSITH KVSLTPPPPP PSKHFEQDLT QEELDHIARI
     AEMADMDYNT PFTAEPVQDE EEEPITESGS DATSGADIFD EQEDASSGAS GSFDNNNAQV
     LTSGFSPDRV TSPAALDTTE EPQGPIMAQK TVSPTPSADS MASRKSSEYD IRSISEIRQE
     SESDIGKWYE EQLSFMRQSI HDEEEDVGHE IRTDVEEFPL EYVEDQLHFL EGIDVESQHH
     EPTTSSAFFG TGRSIGEGEK RKYGDDAVEQ QKLENYEEEE KTKSSSREAF DDGFETQREE
     SLRAQQTPID SLPGSRMLKR PNFGFLSNIA NDAINKAKEA GSQIQAAVPI KPSSSSSNIV
     NNNVFSSSKS STSLGTSAPT KSIPSPQIGI PMDGLSEEER RQIMSVMAAA DFDDSVNNVK
     PSTSGSSNIP AGMEDLSEAE REKIMSVMAN AEMEMGARFP PPSSQIPTRS PSVMSSSIMS
     ELPPGLDDLS DDERMKIMAV MAEADMQNVR KPIARGPPPM PPSTSMIPPG MEGLSEEERQ
     KIMSVMANAE TDSSSSVITS RQPSRSPSVA RMQPQLMPPQ QAIPIIPPGL EGLSDEERHT
     IMSVMAEAEF EESRSQVPSR QPSRSPSFVN PQQSFHPIPS FEPIVPPGLE DLSEEERQKI
     MSVMMNAEVE ESRSQLPSRQ PSRSPSVAMI QAPAVPIIPS GMEDLPEAER QKIMSVMAEA
     EIQNFVPSRS PSNYSMQPVP VIPHGLEDLS EAERQKILSV MAEAEIDSAK IPSRSTSSYS
     MPPPLPQMSQ PEITTGLEHS SEADMEFGRD SSRSHQVIPP GLENLSEEER QQIMSVMAHA
     ELESIIPSGH IDQPISLPRG HTGFKPAGIV NEDELFETER KQREESPTRE SGYATSTSYE
     RELAMGDEER MDGLLEDIIR IREGARSRRD SRDEVLHRRE EDPEVHTPEE SSTAVVTDVP
     SVSPVTENVP EKQTDDFDFT YSDSRFAEIV QMQEEEEAGS LQKQKVDEKP RMWETVFDGD
     ESELPHQDFV FNEPTTKKTS DFDFPKETDE VFEKPSEIQR IRVTKNHDVD MDEIYDNVIA
     TEAPSSVSQR RQPVDSETSV KSRTIQRGPT KPPPMIKITV EEETKSDSDE ESCSEDDEEY
     PDRVVAAPTA PAPTFEEVEN ERIRQEELGK EVLQQIMAFG EVANDEFDVQ WAKTTTSQTP
     STSTKPTVTA PKRSDPIPIA PSQRSKEIEE ERIRTEALEE EEFYRHGHNP FLESPEEDEV
     SINMEDVEYA EIARLYESAN QTMRRPGPVY TITEDESEDD GTLSNSESRL VAREKRLMDK
     KTADSLMAKY QKMKKVQAKQ TTTASSTSVT ATPAYAIINF SDLKTSTRTT DSNSYFETTK
     NIPALEIKDP KKDIPPEISA SIDKTMAEVD ALLGQVYTNE KAIPNLLCFD QSNFSNHPPT
     SSASTSTADD LILLKNNNSS SPSFLLPLQS SVLGSQLDSV RDDNERNENE TTSPRGLKRS
     PGMLLPSPTS TSIFPMPPTA AESVGAAIGA TTASMFGGIS VADPPPTMDG LTNSYKWLQN
     IEDDGNLANN DMGRRKLPSI PPNSSAFPPP TSVTTNVIST DTSMPSTSSG PAPTYVDDYN
     VTLPSDPIVA ESLLKGGSLT RRHQHQQQHQ APVYITSSAS RPPSAAGSNI FQESRPTSSL
     SMYQNDVILS RPGSAASNYT TASTINPTIL AGASYSSKAS SHIRQPVSVR SPRAQTGTTQ
     TTAASGSASN SIRPSIGSSS VTTRVPNTLA RVLLKKELKD VLIQRKQRLE ATEIEANQRH
     YKVQKMLITG LLPEKPEDDI PNIVKCDLPA DLVRGVHISM QPPSPAVSAF SPRRYHHPTS
     VASHQSHPST FKHMSKSIAC QADELPPVKP MISLRTQLDM ERRPQLMTYV GKRSAETQTE
     LANYESITPT VRYGSIPRSS RERTASRRYR EQQQQIYNQM PQNHNDLLEI TKKYFEDYDR
     QLREFGERAR RHSRRRFDFH DDDDQDDMRK NQVMHELARR KERMCASCEI LSTTDPIRTA
     LNPNVPMSSD YSSHVPHYGS LPRIDYPRGT RSDVRDFTYR QQHLPQQPPT NYSYNYGSLP
     RNFERGFSDL PPIEIENEQS FGAPPRHRSN LGYESTSMFN LSDPVYLGYD SIPMVQHQQP
     RVYDQIPSGY AQDTTNLNSL NQGVRGSDMV SQYASYLNSQ FQSGLQQSAQ LPQPMIPITR
     YDAPMSDPYV SSRSRLVDQM NQGYNSNQYH HHSTLLAPKS AQMTHIAPTY NQLAQQQGIP
     MQNTQMDPLM MSSGRIPSSS SQVYSRNEMN YGSRPAQSSL FEYGNRRQYG AAPPPTYDVP
     NVSSASDWRT TQQQGLIQQM PMQMQQQQHN TFDARWPKED ALSRMYATAS RRRAQETALT
     SSNKISTGSR SYARRPIRPS SYRNPEATNS MPDRHVARRT AENSRYDVKR ILLTRSYKHH
     NIYNDLGVRV VGGKRQMNGE LSAYVSQLHS TANNQTLGQI KIGDEVVEWN GILLRGKTFE
     EVERIVNKSH GEIEMVIRTY KNPSSGVYDT LPLNRNTMRD DLSPDRVPPV PMHRINGINN
     NSVLHHHTLS DSSCHGHIQV SLGYDGNSRL VAKIIRARGL KSRDQSRSAP NPFVKVYLLP
     GRKVSHKRRT RFVDSSCAPE WNQVLEYQVA PHTLNTMFLE FTVCDYQRDV DDLPLGNVQI
     PLADKSAINT GPRWYPLQGS YDQPIPQHYM NGTSLSQIPS IAAASKHSAA VHNHHNHNYS
     EVPPSILYPK GGVGTRHPDK PVRHATFNYN PVSLDIGYPA IN
 
 
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