ID   CLAVD_STYCL             Reviewed;          80 AA.
AC   P80713; O18491;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Clavanin-D;
DE   Flags: Precursor;
OS   Styela clava (Sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Styelidae; Styela.
OX   NCBI_TaxID=7725;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hemocyte, and Pharynx;
RX   PubMed=9237689; DOI=10.1016/s0014-5793(97)00646-7;
RA   Zhao C., Lian H., Lee I.H., Lehrer R.I.;
RT   "cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.";
RL   FEBS Lett. 410:490-492(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-52, AND AMIDATION AT PHE-52.
RC   TISSUE=Hemocyte;
RX   PubMed=9001389; DOI=10.1016/s0014-5793(96)01374-9;
RA   Lee I.H., Zhao C., Cho Y., Harwig S.S.L., Cooper E.L., Lehrer R.I.;
RT   "Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes.";
RL   FEBS Lett. 400:158-162(1997).
CC   -!- FUNCTION: Has antimicrobial activity against E.coli, L.monocytogenes
CC       and C.albicans.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Hemocytes and pharyngeal tissues.
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DR   EMBL; Y11019; CAA71901.1; -; mRNA.
DR   EMBL; Y10407; CAA71426.1; -; mRNA.
DR   AlphaFoldDB; P80713; -.
DR   SMR; P80713; -.
DR   TCDB; 1.C.17.3.1; the cecropin (cecropin) family.
DR   PRIDE; P80713; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR008453; Clavanin.
DR   Pfam; PF05452; Clavanin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..29
FT                   /evidence="ECO:0000269|PubMed:9001389"
FT                   /id="PRO_0000020942"
FT   PEPTIDE         30..52
FT                   /note="Clavanin-D"
FT                   /id="PRO_0000020943"
FT   PROPEP          54..80
FT                   /id="PRO_0000020944"
FT   MOD_RES         52
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9001389"
SQ   SEQUENCE   80 AA;  9155 MW;  FECE508C4F3E9BB1 CRC64;
     MKTTILILLI LGLGINAKSL EERKSEEEKA FKLLGRIIHH VGNFVYGFSH VFGDDQQDNG
     KFYGHYAEDN GKHWYDTGDQ