ID   CLAVE_STYCL             Reviewed;          80 AA.
AC   O18492;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Clavanin-E;
DE   Flags: Precursor;
OS   Styela clava (Sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Styelidae; Styela.
OX   NCBI_TaxID=7725;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-52.
RC   TISSUE=Hemocyte, and Pharynx;
RX   PubMed=9237689; DOI=10.1016/s0014-5793(97)00646-7;
RA   Zhao C., Lian H., Lee I.H., Lehrer R.I.;
RT   "cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.";
RL   FEBS Lett. 410:490-492(1997).
CC   -!- FUNCTION: Has antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; Y11018; CAA71900.1; -; mRNA.
DR   EMBL; Y10408; CAA71427.1; -; mRNA.
DR   AlphaFoldDB; O18492; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR008453; Clavanin.
DR   Pfam; PF05452; Clavanin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..29
FT                   /id="PRO_0000020945"
FT   PEPTIDE         30..52
FT                   /note="Clavanin-E"
FT                   /id="PRO_0000020946"
FT   PROPEP          54..80
FT                   /id="PRO_0000020947"
FT   MOD_RES         52
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9237689"
SQ   SEQUENCE   80 AA;  9169 MW;  E2BE437D8DFF9749 CRC64;
     MKTTILILLI LGLGINAKSL EERKSEEEKL FKLLGKIIHH VGNFVHGFSH VFGDDQQDNG
     KFYGYYAEDN GKHWYDTGDQ