ID   CLC11_RAT               Reviewed;         328 AA.
AC   O88201; Q5EAN4;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=C-type lectin domain family 11 member A;
DE   AltName: Full=Lymphocyte secreted C-type lectin;
DE   AltName: Full=Osteolectin {ECO:0000250|UniProtKB:O88200};
DE   AltName: Full=Stem cell growth factor;
DE   Flags: Precursor;
GN   Name=Clec11a; Synonyms=Scgf;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:BAA32406.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone {ECO:0000312|EMBL:BAA32406.1};
RX   PubMed=9705843; DOI=10.1006/bbrc.1998.9073;
RA   Mio H., Kagami N., Yokokawa S., Kawai H., Nakagawa S., Takeuchi K.,
RA   Sekine S., Hiraoka A.;
RT   "Isolation and characterization of a cDNA for human, mouse, and rat full-
RT   length stem cell growth factor, a new member of C-type lectin
RT   superfamily.";
RL   Biochem. Biophys. Res. Commun. 249:124-130(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Promotes osteogenesis by stimulating the differentiation of
CC       mesenchymal progenitors into mature osteoblasts. Important for repair
CC       and maintenance of adult bone. {ECO:0000250|UniProtKB:O88200}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y240}.
CC       Secreted {ECO:0000250|UniProtKB:Q9Y240}.
CC   -!- PTM: O-glycosylated. Probably sulfated on the O-glycans.
CC       {ECO:0000250|UniProtKB:Q9Y240}.
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DR   EMBL; AB009246; BAA32406.1; -; mRNA.
DR   EMBL; BC090344; AAH90344.1; -; mRNA.
DR   RefSeq; NP_001012477.1; NM_001012459.1.
DR   AlphaFoldDB; O88201; -.
DR   SMR; O88201; -.
DR   STRING; 10116.ENSRNOP00000025949; -.
DR   PhosphoSitePlus; O88201; -.
DR   PaxDb; O88201; -.
DR   PRIDE; O88201; -.
DR   Ensembl; ENSRNOT00000025949; ENSRNOP00000025949; ENSRNOG00000019138.
DR   GeneID; 29313; -.
DR   KEGG; rno:29313; -.
DR   UCSC; RGD:3627; rat.
DR   CTD; 6320; -.
DR   RGD; 3627; Clec11a.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00950000183186; -.
DR   HOGENOM; CLU_074832_0_0_1; -.
DR   InParanoid; O88201; -.
DR   OMA; FAWHRSP; -.
DR   OrthoDB; 1236353at2759; -.
DR   PhylomeDB; O88201; -.
DR   TreeFam; TF330481; -.
DR   PRO; PR:O88201; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019138; Expressed in quadriceps femoris and 18 other tissues.
DR   Genevisible; O88201; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; NAS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0001503; P:ossification; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Disulfide bond; Glycoprotein; Growth factor; Lectin;
KW   Osteogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y240"
FT   CHAIN           22..328
FT                   /note="C-type lectin domain family 11 member A"
FT                   /id="PRO_0000017470"
FT   DOMAIN          188..325
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          58..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        209..324
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        301..316
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   328 AA;  36388 MW;  C115188AC23D6257 CRC64;
     MQAAWLLGAL LVPHLLSFGH GARGHGKEWE GVWGGALEEE RDRESLMLKN LQEALGLPTG
     VGNKDNLAEN SEGKEVWEAT ETQGEEEEEE TTTTPSSSPT PFPSPSPTSE DTVTYILGRL
     ASLDAGLHQL HIRLHVLDTR VVELTQGLRR LRDAASDTRD SVQALKEVQV RSEQEHGRLE
     GCLKGLRLGH KCFLLSRDFE TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN
     WPVWLGVHDR RSEGLYLFEN GQRVSFFAWH RALSPESGAQ PSAASHPLSP DQPNGGILEN
     CVAQASDDGS WWDHDCERRL YFVCEFPF