CLC14_MOUSE
ID CLC14_MOUSE Reviewed; 459 AA.
AC Q8VCP9; Q3TP72; Q9CXA8; Q9D624; Q9DC55;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-SEP-2003, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=C-type lectin domain family 14 member A;
DE Flags: Precursor;
GN Name=Clec14a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic lung, Head, Lung, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK004557; BAB23370.2; -; mRNA.
DR EMBL; AK014681; BAB29502.1; -; mRNA.
DR EMBL; AK018432; BAB31209.1; -; mRNA.
DR EMBL; AK033733; BAC28454.1; -; mRNA.
DR EMBL; AK045596; BAC32430.1; -; mRNA.
DR EMBL; AK080201; BAC37846.1; -; mRNA.
DR EMBL; AK164665; BAE37865.1; -; mRNA.
DR EMBL; BC019452; AAH19452.1; -; mRNA.
DR CCDS; CCDS25930.1; -.
DR RefSeq; NP_080085.3; NM_025809.5.
DR AlphaFoldDB; Q8VCP9; -.
DR SMR; Q8VCP9; -.
DR STRING; 10090.ENSMUSP00000054451; -.
DR GlyGen; Q8VCP9; 4 sites.
DR iPTMnet; Q8VCP9; -.
DR PhosphoSitePlus; Q8VCP9; -.
DR MaxQB; Q8VCP9; -.
DR PaxDb; Q8VCP9; -.
DR PeptideAtlas; Q8VCP9; -.
DR PRIDE; Q8VCP9; -.
DR ProteomicsDB; 279098; -.
DR Antibodypedia; 23322; 203 antibodies from 29 providers.
DR DNASU; 66864; -.
DR Ensembl; ENSMUST00000062254; ENSMUSP00000054451; ENSMUSG00000045930.
DR GeneID; 66864; -.
DR KEGG; mmu:66864; -.
DR UCSC; uc007npv.2; mouse.
DR CTD; 161198; -.
DR MGI; MGI:1914114; Clec14a.
DR VEuPathDB; HostDB:ENSMUSG00000045930; -.
DR eggNOG; ENOG502S0KN; Eukaryota.
DR GeneTree; ENSGT00930000151088; -.
DR HOGENOM; CLU_593913_0_0_1; -.
DR InParanoid; Q8VCP9; -.
DR OMA; EMRCHLR; -.
DR OrthoDB; 747312at2759; -.
DR PhylomeDB; Q8VCP9; -.
DR TreeFam; TF330714; -.
DR BioGRID-ORCS; 66864; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8VCP9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8VCP9; protein.
DR Bgee; ENSMUSG00000045930; Expressed in brain blood vessel and 178 other tissues.
DR Genevisible; Q8VCP9; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0050840; F:extracellular matrix binding; IBA:GO_Central.
DR GO; GO:1990430; F:extracellular matrix protein binding; ISO:MGI.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IMP:MGI.
DR GO; GO:0001946; P:lymphangiogenesis; IMP:MGI.
DR GO; GO:0002040; P:sprouting angiogenesis; IMP:MGI.
DR GO; GO:0036324; P:vascular endothelial growth factor receptor-2 signaling pathway; IMP:MGI.
DR GO; GO:0036325; P:vascular endothelial growth factor receptor-3 signaling pathway; IMP:MGI.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..459
FT /note="C-type lectin domain family 14 member A"
FT /id="PRO_0000017378"
FT TOPO_DOM 22..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 33..173
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DOMAIN 246..288
FT /note="EGF-like"
FT MOD_RES 440
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 143..162
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CONFLICT 30
FT /note="A -> R (in Ref. 1; BAB31209)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="T -> P (in Ref. 1; BAB23370)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="T -> A (in Ref. 2; AAH19452)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="I -> V (in Ref. 2; AAH19452)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="S -> C (in Ref. 1; BAB23370)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 459 AA; 49066 MW; A257B38DA598EC8A CRC64;
MRPALALCLL CPAFWPRPGN GEHPTADRAA CSASGACYSL HHATFKRRAA EEACSLRGGT
LSTVHSGSEF QAVLLLLRAG PGPGGGSKDL LFWVALERSI SQCTQEKEPL RGFSWLHPDS
EDSEDSPLPW VEEPQRSCTV RKCAALQATR GVEPAGWKEM RCHLRTDGYL CKYQFEVLCP
APRPGAASNL SFQAPFRLSS SALDFSPPGT EVSAMCPGDL SVSSTCIQEE TSAHWDGLFP
GTVLCPCSGR YLLAGKCVEL PDCLDHLGDF TCECAVGFEL GKDGRSCETK VEEQLTLEGT
KLPTRNVTAT PAGAVTNRTW PGQVYDKPGE MPQVTEILQW GTQSTLPTIQ KTPQTKPKVT
GTPSGSVVLN YTSSPPVSLT FDTSSTVVFI LVSIAVIVLV VLTITVLGLF KLCFHKSRSS
RTGKGALDSP GVECDAEATS LHHSSTQCTD IGVKSGTVA
