CLC1A_BOVIN
ID CLC1A_BOVIN Reviewed; 278 AA.
AC Q0VCS6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=C-type lectin domain family 1 member A;
DE AltName: Full=C-type lectin-like receptor 1;
DE Short=CLEC-1;
GN Name=CLEC1A; Synonyms=CLEC1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal lung;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
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DR EMBL; BC120028; AAI20029.1; -; mRNA.
DR RefSeq; NP_001069549.1; NM_001076081.1.
DR AlphaFoldDB; Q0VCS6; -.
DR SMR; Q0VCS6; -.
DR STRING; 9913.ENSBTAP00000019328; -.
DR PaxDb; Q0VCS6; -.
DR PRIDE; Q0VCS6; -.
DR Ensembl; ENSBTAT00000019328; ENSBTAP00000019328; ENSBTAG00000030424.
DR GeneID; 536944; -.
DR KEGG; bta:536944; -.
DR CTD; 51267; -.
DR VEuPathDB; HostDB:ENSBTAG00000030424; -.
DR VGNC; VGNC:27427; CLEC1A.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000161945; -.
DR HOGENOM; CLU_049894_8_0_1; -.
DR InParanoid; Q0VCS6; -.
DR OMA; WLWTDGA; -.
DR OrthoDB; 1201127at2759; -.
DR TreeFam; TF336674; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000030424; Expressed in lung and 97 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Lectin; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..278
FT /note="C-type lectin domain family 1 member A"
FT /id="PRO_0000313577"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 144..258
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 236..249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 278 AA; 32094 MW; B31FA5B249463283 CRC64;
MLAKYSSTRD MLDADGDTTM SLHSQASATS QRPELGHTEH QRPSSAWRPV ALILLTLCLV
LLIGLAALGL VFFQFYQLSN TQQDSILQKE EKLGNLSRQL QSLRTQNRKL AETLHHVAEK
LCRELYNKTG EHRCSPCPEK WKWHGDKCYQ FYKESKSWQG CEYFCIAENS TMLKINTQEV
LEFAMPQSYS EFFYSYWTGL SRNSSGKAWL WMDGTPYSSE LFDVMIDLTS LRSRDCVTIL
NGKAFSKDCR ELRRCACEKA AAMVKVQSLH EPLSRRWR
