CLC1A_HUMAN
ID CLC1A_HUMAN Reviewed; 280 AA.
AC Q8NC01; Q8IUW7; Q9NZH3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=C-type lectin domain family 1 member A;
DE AltName: Full=C-type lectin-like receptor 1;
DE Short=CLEC-1;
GN Name=CLEC1A; Synonyms=CLEC1; ORFNames=UNQ569/PRO1131;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ALA-26.
RX PubMed=10671229;
RX DOI=10.1002/1521-4141(200002)30:2<697::aid-immu697>3.0.co;2-m;
RA Colonna M., Samaridis J., Angman L.;
RT "Molecular characterization of two novel C-type lectin-like receptors, one
RT of which is selectively expressed in human dendritic cells.";
RL Eur. J. Immunol. 30:697-704(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-26.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-26.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-26.
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NC01; Q9HA82: CERS4; NbExp=3; IntAct=EBI-11996768, EBI-2622997;
CC Q8NC01; Q5QGZ9: CLEC12A; NbExp=3; IntAct=EBI-11996768, EBI-13335829;
CC Q8NC01; O15552: FFAR2; NbExp=3; IntAct=EBI-11996768, EBI-2833872;
CC Q8NC01; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-11996768, EBI-12142257;
CC Q8NC01; P48165: GJA8; NbExp=3; IntAct=EBI-11996768, EBI-17458373;
CC Q8NC01; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11996768, EBI-13345167;
CC Q8NC01; Q8TED1: GPX8; NbExp=3; IntAct=EBI-11996768, EBI-11721746;
CC Q8NC01; Q8N386: LRRC25; NbExp=3; IntAct=EBI-11996768, EBI-11304917;
CC Q8NC01; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-11996768, EBI-3925442;
CC Q8NC01; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-11996768, EBI-750085;
CC Q8NC01; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-11996768, EBI-2466594;
CC Q8NC01; Q16623: STX1A; NbExp=3; IntAct=EBI-11996768, EBI-712466;
CC Q8NC01; Q8N609: TRAM1L1; NbExp=3; IntAct=EBI-11996768, EBI-11996766;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in dendritic cells.
CC {ECO:0000269|PubMed:10671229}.
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DR EMBL; AF200949; AAF36830.1; -; mRNA.
DR EMBL; AY358587; AAQ88950.1; -; mRNA.
DR EMBL; AK075114; BAC11410.1; -; mRNA.
DR EMBL; BC039072; AAH39072.1; -; mRNA.
DR EMBL; BC067746; AAH67746.1; -; mRNA.
DR CCDS; CCDS8612.1; -.
DR RefSeq; NP_001284677.1; NM_001297748.1.
DR RefSeq; NP_001284678.1; NM_001297749.1.
DR RefSeq; NP_001284679.1; NM_001297750.1.
DR RefSeq; NP_001284680.1; NM_001297751.1.
DR RefSeq; NP_057595.2; NM_016511.3.
DR AlphaFoldDB; Q8NC01; -.
DR SMR; Q8NC01; -.
DR BioGRID; 119421; 17.
DR IntAct; Q8NC01; 15.
DR STRING; 9606.ENSP00000326407; -.
DR GlyGen; Q8NC01; 2 sites.
DR PhosphoSitePlus; Q8NC01; -.
DR BioMuta; CLEC1A; -.
DR DMDM; 116241301; -.
DR MassIVE; Q8NC01; -.
DR PaxDb; Q8NC01; -.
DR PeptideAtlas; Q8NC01; -.
DR PRIDE; Q8NC01; -.
DR ProteomicsDB; 72840; -.
DR Antibodypedia; 23227; 233 antibodies from 25 providers.
DR DNASU; 51267; -.
DR Ensembl; ENST00000315330.8; ENSP00000326407.4; ENSG00000150048.10.
DR GeneID; 51267; -.
DR KEGG; hsa:51267; -.
DR MANE-Select; ENST00000315330.8; ENSP00000326407.4; NM_016511.4; NP_057595.2.
DR UCSC; uc001qxb.4; human.
DR CTD; 51267; -.
DR DisGeNET; 51267; -.
DR GeneCards; CLEC1A; -.
DR HGNC; HGNC:24355; CLEC1A.
DR HPA; ENSG00000150048; Tissue enhanced (lymphoid tissue, placenta).
DR MalaCards; CLEC1A; -.
DR MIM; 606782; gene.
DR neXtProt; NX_Q8NC01; -.
DR OpenTargets; ENSG00000150048; -.
DR PharmGKB; PA142672097; -.
DR VEuPathDB; HostDB:ENSG00000150048; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000161945; -.
DR InParanoid; Q8NC01; -.
DR OMA; WLWTDGA; -.
DR OrthoDB; 1201127at2759; -.
DR PhylomeDB; Q8NC01; -.
DR TreeFam; TF336674; -.
DR PathwayCommons; Q8NC01; -.
DR SignaLink; Q8NC01; -.
DR BioGRID-ORCS; 51267; 7 hits in 1063 CRISPR screens.
DR ChiTaRS; CLEC1A; human.
DR GeneWiki; CLEC1A; -.
DR GenomeRNAi; 51267; -.
DR Pharos; Q8NC01; Tbio.
DR PRO; PR:Q8NC01; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NC01; protein.
DR Bgee; ENSG00000150048; Expressed in placenta and 118 other tissues.
DR ExpressionAtlas; Q8NC01; baseline and differential.
DR Genevisible; Q8NC01; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..280
FT /note="C-type lectin domain family 1 member A"
FT /id="PRO_0000046609"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 144..258
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 236..249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VARIANT 26
FT /note="G -> A (in dbSNP:rs2306894)"
FT /evidence="ECO:0000269|PubMed:10671229,
FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_050106"
FT CONFLICT 68
FT /note="L -> W (in Ref. 1; AAF36830)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 31952 MW; 138235ED47553F4B CRC64;
MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV ALTLLTLCLV
LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL QSLQVQNIKL AGSLQHVAEK
LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ FYKDSKSWED CKYFCLSENS TMLKINKQED
LEFAASQSYS EFFYSYWTGL LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL
NGMIFSKDCK ELKRCVCERR AGMVKPESLH VPPETLGEGD
