CLC1A_MOUSE
ID CLC1A_MOUSE Reviewed; 269 AA.
AC Q8BWY2; Q7TPX7; Q8BMH5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=C-type lectin domain family 1 member A;
GN Name=Clec1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
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DR EMBL; AK031121; BAC27264.1; -; mRNA.
DR EMBL; AK049608; BAC33840.1; -; mRNA.
DR EMBL; BC052840; AAH52840.1; -; mRNA.
DR CCDS; CCDS20587.1; -.
DR RefSeq; NP_001334404.1; NM_001347475.1.
DR RefSeq; NP_780735.2; NM_175526.3.
DR AlphaFoldDB; Q8BWY2; -.
DR SMR; Q8BWY2; -.
DR STRING; 10090.ENSMUSP00000047065; -.
DR GlyGen; Q8BWY2; 4 sites.
DR iPTMnet; Q8BWY2; -.
DR PhosphoSitePlus; Q8BWY2; -.
DR MaxQB; Q8BWY2; -.
DR PaxDb; Q8BWY2; -.
DR PRIDE; Q8BWY2; -.
DR ProteomicsDB; 279099; -.
DR Antibodypedia; 23227; 233 antibodies from 25 providers.
DR DNASU; 243653; -.
DR Ensembl; ENSMUST00000037481; ENSMUSP00000047065; ENSMUSG00000033082.
DR GeneID; 243653; -.
DR KEGG; mmu:243653; -.
DR UCSC; uc009eft.2; mouse.
DR CTD; 51267; -.
DR MGI; MGI:2444151; Clec1a.
DR VEuPathDB; HostDB:ENSMUSG00000033082; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000161945; -.
DR HOGENOM; CLU_049894_8_0_1; -.
DR InParanoid; Q8BWY2; -.
DR OMA; WLWTDGA; -.
DR OrthoDB; 1201127at2759; -.
DR PhylomeDB; Q8BWY2; -.
DR TreeFam; TF336674; -.
DR BioGRID-ORCS; 243653; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Clec1a; mouse.
DR PRO; PR:Q8BWY2; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BWY2; protein.
DR Bgee; ENSMUSG00000033082; Expressed in left lung lobe and 113 other tissues.
DR ExpressionAtlas; Q8BWY2; baseline and differential.
DR Genevisible; Q8BWY2; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..269
FT /note="C-type lectin domain family 1 member A"
FT /id="PRO_0000046610"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 143..257
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 164..256
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 235..248
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CONFLICT 6
FT /note="S -> G (in Ref. 2; AAH52840)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="E -> Q (in Ref. 1; BAC27264)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="T -> N (in Ref. 1; BAC27264)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 30958 MW; DEC53DB093451ED0 CRC64;
MQAKYSSTRD MLDDDDTTIS LYSGTSTVTR RAEPRHSENG TPSSVWRPVA LTLLTLCLVL
LVGLAALGLV FFQFYQLSNI QQDSITEKDE KLGNMSRQLQ SLQAQNRKLI ETLQQVAVKL
CRELYNKSGG HRCSPCPEKW KWYGDKCYQF YKESKNWQSC EYFCLADNAT MLKISTQEEL
DFAMPQSYSE FFYSYWTGLS RNGSGKAWLW TDGTPYSFEL FEIIIDPTNL RNRDCMTIFN
GKAYSKDCKE LRRCACERIA GRVVPGELQ
