CLC2E_MOUSE
ID CLC2E_MOUSE Reviewed; 204 AA.
AC Q80XD9; Q8VI18;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=C-type lectin domain family 2 member E;
DE AltName: Full=C-type lectin-related protein A;
DE Short=Clr-a;
GN Name=Clec2e; Synonyms=Clra;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=11398965; DOI=10.1007/s002510100319;
RA Plougastel B., Dubbelde C., Yokoyama W.M.;
RT "Cloning of Clr, a new family of lectin-like genes localized between mouse
RT Nkrp1a and Cd69.";
RL Immunogenetics 53:209-214(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Lectin-type cell surface receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
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DR EMBL; AF320600; AAL37200.1; -; Genomic_DNA.
DR EMBL; BC051091; AAH51091.1; -; mRNA.
DR AlphaFoldDB; Q80XD9; -.
DR SMR; Q80XD9; -.
DR STRING; 10090.ENSMUSP00000032258; -.
DR GlyGen; Q80XD9; 1 site.
DR PaxDb; Q80XD9; -.
DR PRIDE; Q80XD9; -.
DR ProteomicsDB; 285466; -.
DR MGI; MGI:3028921; Clec2e.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; Q80XD9; -.
DR PhylomeDB; Q80XD9; -.
DR ChiTaRS; Clec2e; mouse.
DR PRO; PR:Q80XD9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80XD9; protein.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..204
FT /note="C-type lectin domain family 2 member E"
FT /id="PRO_0000315287"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..59
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 84..188
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 77..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 105..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CONFLICT 27
FT /note="G -> R (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 31
FT /note="A -> T (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="V -> S (in Ref. 1; AAL37200)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="T -> A (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="S -> P (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="H -> R (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="N -> S (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="R -> C (in Ref. 2; AAH51091)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22754 MW; 4BA3229004C1C2BC CRC64;
MLKTDLTAPD CLQEGEMGKK LQAKCLGIIS AASCVKLYCC YGVIMVLTVA VVALSVTLSV
RKKKPVMESC EPCYAVCSSG WIGFGNKCFY FSEDMGNWTF SQSSCIALDA HLALFDSLEE
LNFLKRYKGA SDHWIGLHRE SSEHPWIWTD NTEYNNLVLT RGGGECAYLS NRGIYNSSGD
IHKKWICNKP NNYTLQRPLI VNPG
