CLC2H_MOUSE
ID CLC2H_MOUSE Reviewed; 218 AA.
AC Q8C1T8; Q78IZ7; Q924B2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=C-type lectin domain family 2 member H;
DE AltName: Full=C-type lectin-related protein F;
DE Short=Clr-f;
GN Name=Clec2h; Synonyms=Clrf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Natural killer cell;
RX PubMed=11398965; DOI=10.1007/s002510100319;
RA Plougastel B., Dubbelde C., Yokoyama W.M.;
RT "Cloning of Clr, a new family of lectin-like genes localized between mouse
RT Nkrp1a and Cd69.";
RL Immunogenetics 53:209-214(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Intestinal mucosa;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-8.
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Lectin-type cell surface receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in ileum, liver, kidney and in IL2-
CC activated natural killer cells. {ECO:0000269|PubMed:11398965}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK70358.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF350410; AAK70358.1; ALT_INIT; mRNA.
DR EMBL; AK090364; BAC41184.1; -; mRNA.
DR EMBL; BC021766; AAH21766.2; -; mRNA.
DR CCDS; CCDS20576.1; -.
DR RefSeq; NP_444395.2; NM_053165.5.
DR AlphaFoldDB; Q8C1T8; -.
DR SMR; Q8C1T8; -.
DR STRING; 10090.ENSMUSP00000032518; -.
DR GlyGen; Q8C1T8; 1 site.
DR iPTMnet; Q8C1T8; -.
DR PhosphoSitePlus; Q8C1T8; -.
DR PaxDb; Q8C1T8; -.
DR PRIDE; Q8C1T8; -.
DR ProteomicsDB; 283365; -.
DR DNASU; 94071; -.
DR Ensembl; ENSMUST00000032518; ENSMUSP00000032518; ENSMUSG00000030364.
DR GeneID; 94071; -.
DR KEGG; mmu:94071; -.
DR UCSC; uc009eek.2; mouse.
DR CTD; 94071; -.
DR MGI; MGI:2136934; Clec2h.
DR VEuPathDB; HostDB:ENSMUSG00000030364; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155319; -.
DR HOGENOM; CLU_049894_8_1_1; -.
DR InParanoid; Q8C1T8; -.
DR OMA; THRKWIC; -.
DR OrthoDB; 1289964at2759; -.
DR PhylomeDB; Q8C1T8; -.
DR TreeFam; TF351467; -.
DR BioGRID-ORCS; 94071; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Clec2h; mouse.
DR PRO; PR:Q8C1T8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8C1T8; protein.
DR Bgee; ENSMUSG00000030364; Expressed in epithelium of small intestine and 62 other tissues.
DR ExpressionAtlas; Q8C1T8; baseline and differential.
DR Genevisible; Q8C1T8; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
DR GO; GO:0030246; F:carbohydrate binding; ISS:MGI.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:MGI.
DR GO; GO:0006968; P:cellular defense response; TAS:MGI.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..218
FT /note="C-type lectin domain family 2 member H"
FT /id="PRO_0000315290"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 97..201
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 118..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VARIANT 8
FT /note="T -> M (in strain: FVB/N)"
FT /evidence="ECO:0000269|PubMed:15489334"
SQ SEQUENCE 218 AA; 24162 MW; F041169652E02CA7 CRC64;
MNAAKVETSS MGMLQRADLT AADCLQEGEM GKKIQGKCFR IISTVSPVKL YCCYGVIMVL
TVAVIALSVA LSVRNKIPAM EDREPCYTAC PSGWIGFGSK CFYFSEDMGN WTFSQSSCVA
SNSHLALFHS LEELNFLKRY KGTSDHWIGL HRASTQHPWI WTDNTEYSNL VLTRGGGECG
FLSDNGISSG RSYTHRKWIC SKFVSSCKSR VGSVPRHV
