CLC2L_HUMAN
ID CLC2L_HUMAN Reviewed; 214 AA.
AC P0C7M8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=C-type lectin domain family 2 member L;
GN Name=CLEC2L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC005531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47724.1; -.
DR RefSeq; NP_001073980.2; NM_001080511.2.
DR AlphaFoldDB; P0C7M8; -.
DR SMR; P0C7M8; -.
DR BioGRID; 127555; 2.
DR STRING; 9606.ENSP00000390661; -.
DR iPTMnet; P0C7M8; -.
DR PhosphoSitePlus; P0C7M8; -.
DR BioMuta; CLEC2L; -.
DR DMDM; 190358747; -.
DR MassIVE; P0C7M8; -.
DR PaxDb; P0C7M8; -.
DR PeptideAtlas; P0C7M8; -.
DR PRIDE; P0C7M8; -.
DR ProteomicsDB; 52347; -.
DR Antibodypedia; 52522; 61 antibodies from 15 providers.
DR DNASU; 154790; -.
DR Ensembl; ENST00000422142.7; ENSP00000390661.2; ENSG00000236279.7.
DR GeneID; 154790; -.
DR KEGG; hsa:154790; -.
DR MANE-Select; ENST00000422142.7; ENSP00000390661.2; NM_001080511.4; NP_001073980.2.
DR UCSC; uc010lnd.4; human.
DR CTD; 154790; -.
DR GeneCards; CLEC2L; -.
DR HGNC; HGNC:21969; CLEC2L.
DR HPA; ENSG00000236279; Tissue enhanced (brain, parathyroid gland).
DR neXtProt; NX_P0C7M8; -.
DR OpenTargets; ENSG00000236279; -.
DR PharmGKB; PA142672101; -.
DR VEuPathDB; HostDB:ENSG00000236279; -.
DR eggNOG; KOG1766; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000162503; -.
DR HOGENOM; CLU_1528662_0_0_1; -.
DR InParanoid; P0C7M8; -.
DR OMA; DCLMTRP; -.
DR OrthoDB; 1201127at2759; -.
DR PhylomeDB; P0C7M8; -.
DR TreeFam; TF351467; -.
DR PathwayCommons; P0C7M8; -.
DR SignaLink; P0C7M8; -.
DR BioGRID-ORCS; 154790; 8 hits in 1075 CRISPR screens.
DR GenomeRNAi; 154790; -.
DR Pharos; P0C7M8; Tdark.
DR PRO; PR:P0C7M8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0C7M8; protein.
DR Bgee; ENSG00000236279; Expressed in prefrontal cortex and 127 other tissues.
DR ExpressionAtlas; P0C7M8; baseline and differential.
DR Genevisible; P0C7M8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Lectin; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..214
FT /note="C-type lectin domain family 2 member L"
FT /id="PRO_0000339385"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 107..209
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 32
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0ZCA7"
FT DISULFID 128..208
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 187..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 214 AA; 23927 MW; 5D4A8E589C8670C2 CRC64;
MEPAREPPSR ARPPPPLAAR PAPAPAAPRP RSPAEAEARG PEGLLRRSGS GYEGSTSWKA
ALEDTTTRLL LGAIAVLLFA ILVVMSILAS KGCIKCEAPC PEDWLLYGRK CYFFSEEPRD
WNTGRQYCHT HEAVLAVIQS QKELEFMFKF TRREPWIGLR RVGDEFHWVN GDPFDPDTFT
IAGPGECVFV EPTRLVSTEC LMTRPWVCSK MAYT
