ACHD_BOVIN
ID ACHD_BOVIN Reviewed; 516 AA.
AC P04759;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Acetylcholine receptor subunit delta;
DE Flags: Precursor;
GN Name=CHRND;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3838938; DOI=10.1111/j.1432-1033.1985.tb08885.x;
RA Kubo S., Noda M., Takai T., Tanabe T., Kayano T., Shimizu S., Tanaka K.,
RA Takahashi H., Hirose T., Inayama S., Kikuno R., Miyata T., Numa S.;
RT "Primary structure of delta subunit precursor of calf muscle acetylcholine
RT receptor deduced from cDNA sequence.";
RL Eur. J. Biochem. 149:5-13(1985).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta,
CC and gamma (in immature muscle) or epsilon (in mature muscle) chains.
CC The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon
CC subunits interacts with the alpha-conotoxin ImII (By similarity).
CC {ECO:0000250|UniProtKB:Q07001}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; X02473; CAA26309.1; -; mRNA.
DR PIR; A24613; A24613.
DR RefSeq; NP_776696.1; NM_174271.1.
DR AlphaFoldDB; P04759; -.
DR SMR; P04759; -.
DR STRING; 9913.ENSBTAP00000015135; -.
DR PaxDb; P04759; -.
DR Ensembl; ENSBTAT00000015135; ENSBTAP00000015135; ENSBTAG00000011390.
DR GeneID; 281687; -.
DR KEGG; bta:281687; -.
DR CTD; 1144; -.
DR VEuPathDB; HostDB:ENSBTAG00000011390; -.
DR VGNC; VGNC:27334; CHRND.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000159794; -.
DR HOGENOM; CLU_018074_1_4_1; -.
DR InParanoid; P04759; -.
DR OMA; NFIVSHM; -.
DR OrthoDB; 588360at2759; -.
DR TreeFam; TF315605; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000011390; Expressed in laryngeal cartilage and 51 other tissues.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IEA:Ensembl.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0042166; F:acetylcholine binding; IEA:Ensembl.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050881; P:musculoskeletal movement; IEA:Ensembl.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0048630; P:skeletal muscle tissue growth; IEA:Ensembl.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..21
FT CHAIN 22..516
FT /note="Acetylcholine receptor subunit delta"
FT /id="PRO_0000000321"
FT TOPO_DOM 22..244
FT /note="Extracellular"
FT TRANSMEM 245..269
FT /note="Helical"
FT TRANSMEM 279..296
FT /note="Helical"
FT TRANSMEM 311..332
FT /note="Helical"
FT TOPO_DOM 333..470
FT /note="Cytoplasmic"
FT TRANSMEM 471..493
FT /note="Helical"
FT MOD_RES 389
FT /note="Phosphotyrosine; by Tyr-kinases"
FT /evidence="ECO:0000250"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 150..164
FT /evidence="ECO:0000250"
SQ SEQUENCE 516 AA; 58588 MW; 6EBFA6AC00AB93A0 CRC64;
MEGSVLTLVL LAALVVCGSW GLNEEERLIR HLFEEKAYNK ELRPAAHKES VEISLALTLS
NLISLKEVEE TLTTNVWIEQ GWTDSRLQWD AEDFGNISVL RLPADMVWLP EIVLENNNDG
SFQISYSCNV LIYPSGSVYW LPPAIFRSSC PISVTYFPFD WQNCSLKFSS LKYTTKEITL
SLKQAEEDGR SYPVEWIIID PEGFTENGEW EIVHRPARVN VDPSVPLDSP NRQDVTFYLI
IRRKPLFYVI NILVPCVLIS FMINLVFYLP ADCGEKTSMA ISVLLAQSVF LLLISKRLPA
TSMAIPLIGK FLLFGMVLVT MVVVICVIVL NIHFRTPSTH VLSEPVKKLF LETLPEILHM
SRPAEDGPSP GTLIRRSSSL GYISKAEEYF SLKSRSDLMF EKQSERHGLA RRLTTARRPP
AGSEQAQQEL FSELKPAVDG ANFIVNHMKD QNNYNEEKDC WNRVARTVDR LCLFVVTPIM
VVGTAWIFLQ GAYNQPPPQP FPGDPFSYLE KDKRFI
