ID   CLC2_CAEEL              Reviewed;         252 AA.
AC   Q11085; Q9NGJ8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Clc-like protein 2;
GN   Name=clc-2; Synonyms=clc-4; ORFNames=C01C10.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=Bristol N2;
RX   PubMed=10395899; DOI=10.1016/s0378-1119(99)00199-7;
RA   Agostoni E., Gobessi S., Brancolini C., Schneider C.;
RT   "Identification and characterization of a new member of the gas3/PMP22 gene
RT   family in C. elegans.";
RL   Gene 234:267-274(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC       {ECO:0000269|PubMed:10395899}.
CC   -!- SIMILARITY: Belongs to the Clc family. {ECO:0000305}.
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DR   EMBL; AF252604; AAF67350.1; -; mRNA.
DR   EMBL; FO080255; CCD62382.1; -; Genomic_DNA.
DR   RefSeq; NP_509257.1; NM_076856.4.
DR   AlphaFoldDB; Q11085; -.
DR   STRING; 6239.C01C10.1; -.
DR   TCDB; 1.H.2.2.3; the invertebrate pmp22-claudin (claudin2) family.
DR   PaxDb; Q11085; -.
DR   EnsemblMetazoa; C01C10.1a.1; C01C10.1a.1; WBGene00000523.
DR   GeneID; 180999; -.
DR   KEGG; cel:CELE_C01C10.1; -.
DR   UCSC; C01C10.1; c. elegans.
DR   CTD; 180999; -.
DR   WormBase; C01C10.1a; CE28881; WBGene00000523; clc-2.
DR   eggNOG; ENOG502S5JX; Eukaryota.
DR   HOGENOM; CLU_1112369_0_0_1; -.
DR   InParanoid; Q11085; -.
DR   OMA; PAWQVVY; -.
DR   OrthoDB; 1135009at2759; -.
DR   PhylomeDB; Q11085; -.
DR   PRO; PR:Q11085; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000523; Expressed in embryo and 3 other tissues.
DR   ExpressionAtlas; Q11085; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR   GO; GO:0090136; P:epithelial cell-cell adhesion; IMP:WormBase.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR010761; Clc_prot-like.
DR   Pfam; PF07062; Clc-like; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..252
FT                   /note="Clc-like protein 2"
FT                   /id="PRO_0000089852"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  29062 MW;  2768575CEC55BE06 CRC64;
     MSQAVSYAIL VLTIIAFLLT AAALCTPAWQ VVYAREIRQW VQSGLWLSCQ TRPNGMYSCT
     YTFSHDDFNT YFSDEVSGFR TPSFYPWQRT LFHIYLISQA FAMLSLISFC VSVSHKESKM
     PNILRSVFLV LAAVIAFGCL IAFAVYSYMV EYRFFHVSVS GIYEKHRGYS WYIALTGAFV
     YLVAIILSVV HVLLQARNSN TTMSRQNINS SLQSDFFEYQ YHPNRSMESF EDRFAMRTLP
     PVPRQEKKTT VF