CLC3A_MOUSE
ID CLC3A_MOUSE Reviewed; 196 AA.
AC Q9EPW4;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=C-type lectin domain family 3 member A;
DE AltName: Full=C-type lectin superfamily member 1;
DE AltName: Full=Cartilage-derived C-type lectin;
DE Flags: Precursor;
GN Name=Clec3a; Synonyms=Clecsf1, Gm796;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ES129/Sv;
RA Neame P.J., Grimm D.R.;
RT "Mouse homolog of human CLECSF1, a cartilage derived C-type lectin.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes cell adhesion to laminin and fibronectin.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; AF317204; AAG48620.1; -; Genomic_DNA.
DR CCDS; CCDS22690.1; -.
DR RefSeq; NP_001007224.1; NM_001007223.3.
DR AlphaFoldDB; Q9EPW4; -.
DR SMR; Q9EPW4; -.
DR STRING; 10090.ENSMUSP00000009018; -.
DR PhosphoSitePlus; Q9EPW4; -.
DR MaxQB; Q9EPW4; -.
DR PaxDb; Q9EPW4; -.
DR PRIDE; Q9EPW4; -.
DR ProteomicsDB; 283366; -.
DR Antibodypedia; 30410; 61 antibodies from 13 providers.
DR DNASU; 403395; -.
DR Ensembl; ENSMUST00000009018; ENSMUSP00000009018; ENSMUSG00000008874.
DR GeneID; 403395; -.
DR KEGG; mmu:403395; -.
DR UCSC; uc009nob.2; mouse.
DR CTD; 10143; -.
DR MGI; MGI:2685642; Clec3a.
DR VEuPathDB; HostDB:ENSMUSG00000008874; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00950000183186; -.
DR HOGENOM; CLU_049894_6_0_1; -.
DR InParanoid; Q9EPW4; -.
DR OMA; WIGVADI; -.
DR OrthoDB; 1236353at2759; -.
DR PhylomeDB; Q9EPW4; -.
DR TreeFam; TF330481; -.
DR BioGRID-ORCS; 403395; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9EPW4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9EPW4; protein.
DR Bgee; ENSMUSG00000008874; Expressed in intervertebral disk and 23 other tissues.
DR ExpressionAtlas; Q9EPW4; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..196
FT /note="C-type lectin domain family 3 member A"
FT /id="PRO_0000017375"
FT DOMAIN 74..192
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 68..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 95..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 167..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 196 AA; 22192 MW; 9AE4C809D119E852 CRC64;
MAKNGLVLCI LVVSLLLDQT DGYPSRMKAR KHSKRRVKAK DDDLKSQVEK LWREVNALKE
MQALQTVCLR GTKVHKKCYL ASEGLKHYHE ANEDCISKGG TLVVPRNSDE INALRDYGKR
SLPGVNDFWL GINDMVTEGK FLDVHGFAVS FLNWDRAQPS GGKRENCVLF SQSAQGKWSD
EACRSSKRYI CEFIIP
