CLC4G_MOUSE
ID CLC4G_MOUSE Reviewed; 294 AA.
AC Q8BNX1; Q5I0T7; Q8R188;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=C-type lectin domain family 4 member G;
GN Name=Clec4g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but
CC not galactose, in a Ca(2+)-dependent manner.
CC {ECO:0000250|UniProtKB:Q6UXB4}.
CC -!- INTERACTION:
CC Q8BNX1; P56817: BACE1; Xeno; NbExp=2; IntAct=EBI-11176364, EBI-2433139;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UXB4};
CC Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6UXB4}.
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DR EMBL; AK079992; BAC37800.1; -; mRNA.
DR EMBL; BC025069; AAH25069.1; -; mRNA.
DR EMBL; BC087963; AAH87963.1; -; mRNA.
DR CCDS; CCDS22072.1; -.
DR RefSeq; NP_083741.1; NM_029465.3.
DR AlphaFoldDB; Q8BNX1; -.
DR SMR; Q8BNX1; -.
DR BioGRID; 217802; 1.
DR IntAct; Q8BNX1; 3.
DR MINT; Q8BNX1; -.
DR STRING; 10090.ENSMUSP00000059574; -.
DR GlyGen; Q8BNX1; 4 sites.
DR iPTMnet; Q8BNX1; -.
DR PhosphoSitePlus; Q8BNX1; -.
DR jPOST; Q8BNX1; -.
DR MaxQB; Q8BNX1; -.
DR PaxDb; Q8BNX1; -.
DR PRIDE; Q8BNX1; -.
DR ProteomicsDB; 285469; -.
DR Antibodypedia; 2674; 101 antibodies from 23 providers.
DR DNASU; 75863; -.
DR Ensembl; ENSMUST00000062037; ENSMUSP00000059574; ENSMUSG00000074491.
DR GeneID; 75863; -.
DR KEGG; mmu:75863; -.
DR UCSC; uc009ksp.2; mouse.
DR CTD; 339390; -.
DR MGI; MGI:1923113; Clec4g.
DR VEuPathDB; HostDB:ENSMUSG00000074491; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000161836; -.
DR HOGENOM; CLU_049894_7_2_1; -.
DR InParanoid; Q8BNX1; -.
DR OMA; GQEDCVM; -.
DR OrthoDB; 1442007at2759; -.
DR PhylomeDB; Q8BNX1; -.
DR TreeFam; TF333341; -.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR BioGRID-ORCS; 75863; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8BNX1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BNX1; protein.
DR Bgee; ENSMUSG00000074491; Expressed in left lobe of liver and 40 other tissues.
DR ExpressionAtlas; Q8BNX1; baseline and differential.
DR Genevisible; Q8BNX1; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0097367; F:carbohydrate derivative binding; ISO:MGI.
DR GO; GO:0070061; F:fructose binding; ISO:MGI.
DR GO; GO:0005537; F:mannose binding; ISO:MGI.
DR GO; GO:0030247; F:polysaccharide binding; IDA:MGI.
DR GO; GO:0120274; F:virus coreceptor activity; ISO:MGI.
DR GO; GO:0001618; F:virus receptor activity; ISO:MGI.
DR GO; GO:0046633; P:alpha-beta T cell proliferation; IMP:MGI.
DR GO; GO:0033080; P:immature T cell proliferation in thymus; IMP:MGI.
DR GO; GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.
DR GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IMP:MGI.
DR GO; GO:0002710; P:negative regulation of T cell mediated immunity; IDA:MGI.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:MGI.
DR GO; GO:1903902; P:positive regulation of viral life cycle; ISO:MGI.
DR GO; GO:0002456; P:T cell mediated immunity; IMP:MGI.
DR GO; GO:0046718; P:viral entry into host cell; ISO:MGI.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Disulfide bond; Glycoprotein; Lectin; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..294
FT /note="C-type lectin domain family 4 member G"
FT /id="PRO_0000223692"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 172..287
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT COILED 100..151
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 264..278
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CONFLICT 2
FT /note="N -> S (in Ref. 2; AAH87963)"
FT /evidence="ECO:0000305"
FT CONFLICT 8
FT /note="K -> E (in Ref. 2; AAH87963)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 294 AA; 33327 MW; 020F933346C4787B CRC64;
MNTGEYNKLG SAIEEVSRGQ LGRWECYKQR LFFLVLALLV ATVLWALILS TLLSSASSKL
RVLLSHQDLL RTNASEQKMT LSSLKDDIGA CRNCCSVTKA QLQTTLAEFK DIQAKLMEQE
SILKELQERV TQDLAKASRD RENIRSELFQ ALEAVKRQNS SCEQCPPSWL PFQGSCYYFS
ETQATWDTAQ SYCGGQGAHL VIVRGLNEQG FLSQHTRGRG YWLGLRAVRH LNKIQGYRWV
DGASLNFSHW NSGEPNDSRG HEDCIMMLHS GLWNDAPCTN ERDGWICEKR SSCY
