ID   CLC5_CAEEL              Reviewed;         281 AA.
AC   Q9NGJ7;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Clc-like protein 5;
GN   Name=clc-5; ORFNames=C01C10.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=Bristol N2;
RX   PubMed=10395899; DOI=10.1016/s0378-1119(99)00199-7;
RA   Agostoni E., Gobessi S., Brancolini C., Schneider C.;
RT   "Identification and characterization of a new member of the gas3/PMP22 gene
RT   family in C. elegans.";
RL   Gene 234:267-274(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC       {ECO:0000269|PubMed:10395899}.
CC   -!- SIMILARITY: Belongs to the Clc family. {ECO:0000305}.
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DR   EMBL; AF252605; AAF67351.1; -; mRNA.
DR   EMBL; FO080255; CCD62385.1; -; Genomic_DNA.
DR   RefSeq; NP_509258.1; NM_076857.4.
DR   AlphaFoldDB; Q9NGJ7; -.
DR   TCDB; 1.H.2.2.1; the invertebrate pmp22-claudin (claudin2) family.
DR   EPD; Q9NGJ7; -.
DR   PaxDb; Q9NGJ7; -.
DR   PeptideAtlas; Q9NGJ7; -.
DR   EnsemblMetazoa; C01C10.4.1; C01C10.4.1; WBGene00000526.
DR   GeneID; 181000; -.
DR   KEGG; cel:CELE_C01C10.4; -.
DR   UCSC; C01C10.4; c. elegans.
DR   CTD; 181000; -.
DR   WormBase; C01C10.4; CE28882; WBGene00000526; clc-5.
DR   eggNOG; ENOG502RXPB; Eukaryota.
DR   HOGENOM; CLU_980832_0_0_1; -.
DR   InParanoid; Q9NGJ7; -.
DR   OMA; DTDAHRY; -.
DR   OrthoDB; 1030786at2759; -.
DR   PhylomeDB; Q9NGJ7; -.
DR   PRO; PR:Q9NGJ7; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000526; Expressed in embryo and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR010761; Clc_prot-like.
DR   Pfam; PF07062; Clc-like; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Clc-like protein 5"
FT                   /id="PRO_0000089853"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  32136 MW;  CA84B0A0B56A61CD CRC64;
     MLVFQTKLQK YQLATLISSV ISNFLIFFAT ITPAWQVADD LDADRYVQSG LWLYCPGQAQ
     CWYIFSDSLI NYYEKVDVCR FFLIGDCRKK LLRTPYFFGW HYAVLILNVI SMICMSLCAA
     AVIFSYVKPA RSRISVIMLD VFAGFASLLL CVSLIVFMVN AEMLESKYLI GIKNTYEKEY
     GYSYYLAGLA FVISVITVLF AALVSTYTFL FPEEVADSEY TLKMSNNQFA VRYNNDLPQP
     YQPPMSQLSM QIPSTEHGSY IAGAISPRGD FKSQTRHFYS Y