ACHD_MOUSE
ID ACHD_MOUSE Reviewed; 520 AA.
AC P02716; Q61267;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Acetylcholine receptor subunit delta;
DE Flags: Precursor;
GN Name=Chrnd; Synonyms=Acrd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6096870; DOI=10.1073/pnas.81.24.7970;
RA Lapolla R.J., Mayne K.M., Davidson N.;
RT "Isolation and characterization of a cDNA clone for the complete protein
RT coding region of the delta subunit of the mouse acetylcholine receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:7970-7974(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Boulter J.;
RT "Molecular cloning of the mouse muscle acetylcholine receptor delta
RT subunit.";
RL Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70.
RX PubMed=3244354; DOI=10.1128/mcb.8.12.5257-5267.1988;
RA Crowder C.M., Merlie J.P.;
RT "Stepwise activation of the mouse acetylcholine receptor delta- and gamma-
RT subunit genes in clonal cell lines.";
RL Mol. Cell. Biol. 8:5257-5267(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
RX PubMed=3198687; DOI=10.1083/jcb.107.6.2271;
RA Baldwin T.J., Burden S.J.;
RT "Isolation and characterization of the mouse acetylcholine receptor delta
RT subunit gene: identification of a 148-bp cis-acting region that confers
RT myotube-specific expression.";
RL J. Cell Biol. 107:2271-2279(1988).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta,
CC and gamma (in immature muscle) or epsilon (in mature muscle) chains.
CC The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon
CC subunits interacts with the alpha-conotoxin ImII (By similarity).
CC {ECO:0000250|UniProtKB:Q07001}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; K02582; AAA37157.1; -; mRNA.
DR EMBL; L10076; AAA39803.1; -; mRNA.
DR EMBL; M22380; AAA37155.1; -; Genomic_DNA.
DR EMBL; X13959; CAA32140.1; -; Genomic_DNA.
DR CCDS; CCDS15129.1; -.
DR PIR; A03175; ACMSD1.
DR PIR; I49459; I49459.
DR RefSeq; NP_067611.2; NM_021600.3.
DR AlphaFoldDB; P02716; -.
DR SMR; P02716; -.
DR BioGRID; 197937; 2.
DR ComplexPortal; CPX-252; Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma.
DR ComplexPortal; CPX-257; Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon.
DR STRING; 10090.ENSMUSP00000072983; -.
DR BindingDB; P02716; -.
DR ChEMBL; CHEMBL3038460; -.
DR ChEMBL; CHEMBL3137264; -.
DR GlyGen; P02716; 3 sites.
DR iPTMnet; P02716; -.
DR PhosphoSitePlus; P02716; -.
DR SwissPalm; P02716; -.
DR PaxDb; P02716; -.
DR PRIDE; P02716; -.
DR Antibodypedia; 20219; 197 antibodies from 26 providers.
DR DNASU; 11447; -.
DR Ensembl; ENSMUST00000073252; ENSMUSP00000072983; ENSMUSG00000026251.
DR GeneID; 11447; -.
DR KEGG; mmu:11447; -.
DR UCSC; uc007bwf.2; mouse.
DR CTD; 1144; -.
DR MGI; MGI:87893; Chrnd.
DR VEuPathDB; HostDB:ENSMUSG00000026251; -.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000159794; -.
DR InParanoid; P02716; -.
DR OMA; NFIVSHM; -.
DR OrthoDB; 588360at2759; -.
DR PhylomeDB; P02716; -.
DR TreeFam; TF315605; -.
DR Reactome; R-MMU-629587; Highly sodium permeable postsynaptic acetylcholine nicotinic receptors.
DR BioGRID-ORCS; 11447; 1 hit in 73 CRISPR screens.
DR PRO; PR:P02716; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P02716; protein.
DR Bgee; ENSMUSG00000026251; Expressed in secondary oocyte and 20 other tissues.
DR ExpressionAtlas; P02716; baseline and differential.
DR Genevisible; P02716; MM.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IDA:MGI.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IDA:SynGO.
DR GO; GO:0031594; C:neuromuscular junction; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0042166; F:acetylcholine binding; IGI:MGI.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IGI:MGI.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated ion channel activity; ISO:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; ISO:MGI.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IDA:ComplexPortal.
DR GO; GO:0006812; P:cation transport; ISO:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050881; P:musculoskeletal movement; ISO:MGI.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IGI:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0003009; P:skeletal muscle contraction; ISO:MGI.
DR GO; GO:0048630; P:skeletal muscle tissue growth; ISO:MGI.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..24
FT CHAIN 25..520
FT /note="Acetylcholine receptor subunit delta"
FT /id="PRO_0000000323"
FT TOPO_DOM 25..248
FT /note="Extracellular"
FT TRANSMEM 249..273
FT /note="Helical"
FT TRANSMEM 281..299
FT /note="Helical"
FT TRANSMEM 315..336
FT /note="Helical"
FT TOPO_DOM 337..474
FT /note="Cytoplasmic"
FT TRANSMEM 475..493
FT /note="Helical"
FT MOD_RES 393
FT /note="Phosphotyrosine; by Tyr-kinases"
FT /evidence="ECO:0000250"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 154..168
FT /evidence="ECO:0000250"
FT CONFLICT 387..388
FT /note="IC -> TA (in Ref. 2; AAA39803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 59143 MW; C46177ACA4A9B4A9 CRC64;
MAGPVLTLGL LAALVVCALP GSWGLNEEQR LIQHLFNEKG YDKDLRPVAR KEDKVDVALS
LTLSNLISLK EVEETLTTNV WIDHAWVDSR LQWDANDFGN ITVLRLPPDM VWLPEIVLEN
NNDGSFQISY ACNVLVYDSG YVTWLPPAIF RSSCPISVTY FPFDWQNCSL KFSSLKYTAK
EITLSLKQEE ENNRSYPIEW IIIDPEGFTE NGEWEIVHRA AKLNVDPSVP MDSTNHQDVT
FYLIIRRKPL FYIINILVPC VLISFMINLV FYLPGDCGEK TSVAISVLLA QSVFLLLISK
RLPATSMAIP LVGKFLLFGM VLVTMVVVIC VIVLNIHFRT PSTHVLSEGV KKFFLETLPK
LLHMSRPAEE DPGPRALIRR SSSLGYICKA EEYFSLKSRS DLMFEKQSER HGLARRLTTA
RRPPASSEQV QQELFNEMKP AVDGANFIVN HMRDQNSYNE EKDNWNQVAR TVDRLCLFVV
TPVMVVGTAW IFLQGVYNQP PLQPFPGDPF SYSEQDKRFI
