CLCB_DICDI
ID CLCB_DICDI Reviewed; 815 AA.
AC Q86AZ6; Q550H1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Chloride channel protein B;
GN Name=clcB; ORFNames=DDB_G0276865;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC several functions including the regulation of cell volume, membrane
CC potential stabilization and signal transduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL68934.1; -; Genomic_DNA.
DR RefSeq; XP_642961.1; XM_637869.1.
DR AlphaFoldDB; Q86AZ6; -.
DR SMR; Q86AZ6; -.
DR STRING; 44689.DDB0233305; -.
DR PaxDb; Q86AZ6; -.
DR EnsemblProtists; EAL68934; EAL68934; DDB_G0276865.
DR GeneID; 8620831; -.
DR KEGG; ddi:DDB_G0276865; -.
DR dictyBase; DDB_G0276865; clcB.
DR eggNOG; KOG0474; Eukaryota.
DR HOGENOM; CLU_003181_4_1_1; -.
DR InParanoid; Q86AZ6; -.
DR OMA; DYDVCEN; -.
DR PhylomeDB; Q86AZ6; -.
DR PRO; PR:Q86AZ6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; SSF54631; 2.
DR SUPFAM; SSF81340; SSF81340; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..815
FT /note="Chloride channel protein B"
FT /id="PRO_0000328044"
FT TOPO_DOM 1..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 607..714
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 768..815
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 654..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 91016 MW; 33257A31E2047AAF CRC64;
MSNNYKAGTA INGNDYLLLN IDGNKDCDTD NGFFSGKNFF GGNQTSITHR RHHKMTTKTD
RELMSHFESL DFNAIDNIIH RKYTFEKKKY QKILKTLGKW VICTLIGVVV GLVCYCLKES
VDQLQSLKLT QVKKFYSTES TIFIPFLVYL GFNLCYGLIS GLLVCIFGPM SSSSGLPEVK
GYLNGIRISK AFNLKTVLGK LVSLIFSFSS GLVLGPEGPM FHIGAGIGSS MSQFKSKTLK
FHLKSFWIFQ NDSDKRDFIS CGAAAGIAAA FGAPIGGVLF CLEEGSSFWS RQLTWRTFFS
CLIATMTANL FLQGFTQQIH DYGVLTFGVS KSYLYTYTEL IPFMIMGIIG GLLGAIFVHV
NVRVNHWRKK LFANKSKLYK MIEVCVIVIL SSVVCFFPAL LADCRPISGI SGLTPGTCDP
GDDSTLILNQ FNCAEGYYNP MATLTLTTLE NSLQIVFSRS TNIFTAQTLL TFSIFYYVLT
IITSGLYVAS GIFIPMMLIG SSWGRLIGIF LSKYFTSIDP SIYALIGAAS MMAGSLRMTI
SLVVIIVELT ETTQYLLPVI LSVMVGKWCG DIFNESIYEH LIELKHIPYL NSQPPNHLRK
KTVAEAMSTD VKTLPEIVKV KTALTILETC PHNGFPVVML PQLHSNSNLN DSNQLSLSLN
LNNNNNNNNN NNNNNNNNNN NNNNNNNNNI LCGLILRSQL SVLLRRKIFN SPEDLKNIDF
ISDKGYNLPI DHTEFSQELA SKIPPIHELS KLITKEDLDM YIDLRPYMNF AVVSIKNYSS
LSEAYQIFRQ VGLRHMVVIN VFNNVVGMLT RKDLC
