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CLCB_DICDI
ID   CLCB_DICDI              Reviewed;         815 AA.
AC   Q86AZ6; Q550H1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Chloride channel protein B;
GN   Name=clcB; ORFNames=DDB_G0276865;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC       several functions including the regulation of cell volume, membrane
CC       potential stabilization and signal transduction (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000019; EAL68934.1; -; Genomic_DNA.
DR   RefSeq; XP_642961.1; XM_637869.1.
DR   AlphaFoldDB; Q86AZ6; -.
DR   SMR; Q86AZ6; -.
DR   STRING; 44689.DDB0233305; -.
DR   PaxDb; Q86AZ6; -.
DR   EnsemblProtists; EAL68934; EAL68934; DDB_G0276865.
DR   GeneID; 8620831; -.
DR   KEGG; ddi:DDB_G0276865; -.
DR   dictyBase; DDB_G0276865; clcB.
DR   eggNOG; KOG0474; Eukaryota.
DR   HOGENOM; CLU_003181_4_1_1; -.
DR   InParanoid; Q86AZ6; -.
DR   OMA; DYDVCEN; -.
DR   PhylomeDB; Q86AZ6; -.
DR   PRO; PR:Q86AZ6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.580.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; SSF54631; 2.
DR   SUPFAM; SSF81340; SSF81340; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..815
FT                   /note="Chloride channel protein B"
FT                   /id="PRO_0000328044"
FT   TOPO_DOM        1..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          607..714
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          768..815
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          654..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  91016 MW;  33257A31E2047AAF CRC64;
     MSNNYKAGTA INGNDYLLLN IDGNKDCDTD NGFFSGKNFF GGNQTSITHR RHHKMTTKTD
     RELMSHFESL DFNAIDNIIH RKYTFEKKKY QKILKTLGKW VICTLIGVVV GLVCYCLKES
     VDQLQSLKLT QVKKFYSTES TIFIPFLVYL GFNLCYGLIS GLLVCIFGPM SSSSGLPEVK
     GYLNGIRISK AFNLKTVLGK LVSLIFSFSS GLVLGPEGPM FHIGAGIGSS MSQFKSKTLK
     FHLKSFWIFQ NDSDKRDFIS CGAAAGIAAA FGAPIGGVLF CLEEGSSFWS RQLTWRTFFS
     CLIATMTANL FLQGFTQQIH DYGVLTFGVS KSYLYTYTEL IPFMIMGIIG GLLGAIFVHV
     NVRVNHWRKK LFANKSKLYK MIEVCVIVIL SSVVCFFPAL LADCRPISGI SGLTPGTCDP
     GDDSTLILNQ FNCAEGYYNP MATLTLTTLE NSLQIVFSRS TNIFTAQTLL TFSIFYYVLT
     IITSGLYVAS GIFIPMMLIG SSWGRLIGIF LSKYFTSIDP SIYALIGAAS MMAGSLRMTI
     SLVVIIVELT ETTQYLLPVI LSVMVGKWCG DIFNESIYEH LIELKHIPYL NSQPPNHLRK
     KTVAEAMSTD VKTLPEIVKV KTALTILETC PHNGFPVVML PQLHSNSNLN DSNQLSLSLN
     LNNNNNNNNN NNNNNNNNNN NNNNNNNNNI LCGLILRSQL SVLLRRKIFN SPEDLKNIDF
     ISDKGYNLPI DHTEFSQELA SKIPPIHELS KLITKEDLDM YIDLRPYMNF AVVSIKNYSS
     LSEAYQIFRQ VGLRHMVVIN VFNNVVGMLT RKDLC
 
 
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