ACHG_BOVIN
ID ACHG_BOVIN Reviewed; 519 AA.
AC P13536;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Acetylcholine receptor subunit gamma;
DE Flags: Precursor;
GN Name=CHRNG;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6547904; DOI=10.1111/j.1432-1033.1984.tb08348.x;
RA Takai T., Noda M., Furutani Y., Takahashi H., Notake M., Shimizu S.,
RA Kayano T., Tanabe T., Tanaka K., Hirose T., Inayama S., Numa S.;
RT "Primary structure of gamma subunit precursor of calf-muscle acetylcholine
RT receptor deduced from the cDNA sequence.";
RL Eur. J. Biochem. 143:109-115(1984).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta,
CC and gamma (in immature muscle) or epsilon (in mature muscle) chains.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M28307; AAA30351.1; -; mRNA.
DR PIR; I45847; I45847.
DR RefSeq; NP_776698.1; NM_174273.2.
DR AlphaFoldDB; P13536; -.
DR SMR; P13536; -.
DR STRING; 9913.ENSBTAP00000048242; -.
DR PaxDb; P13536; -.
DR PRIDE; P13536; -.
DR Ensembl; ENSBTAT00000053164; ENSBTAP00000048242; ENSBTAG00000045943.
DR GeneID; 281689; -.
DR KEGG; bta:281689; -.
DR CTD; 1146; -.
DR VEuPathDB; HostDB:ENSBTAG00000045943; -.
DR VGNC; VGNC:27336; CHRNG.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000160041; -.
DR HOGENOM; CLU_018074_1_4_1; -.
DR InParanoid; P13536; -.
DR OMA; CVDACNL; -.
DR OrthoDB; 588360at2759; -.
DR TreeFam; TF315605; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000045943; Expressed in laryngeal cartilage and 22 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IDA:SynGO.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT CHAIN 23..519
FT /note="Acetylcholine receptor subunit gamma"
FT /id="PRO_0000000333"
FT TOPO_DOM 23..240
FT /note="Extracellular"
FT TRANSMEM 241..265
FT /note="Helical"
FT TRANSMEM 274..292
FT /note="Helical"
FT TRANSMEM 308..329
FT /note="Helical"
FT TOPO_DOM 330..476
FT /note="Cytoplasmic"
FT TRANSMEM 477..497
FT /note="Helical"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 150..164
FT /evidence="ECO:0000250"
SQ SEQUENCE 519 AA; 58179 MW; B72DE5487F7B5C4E CRC64;
MCGGQRPLFL LPLLAVCLGA KGRNQEERLL GDLMQGYNPH LRPAEHDSDV VNVSLKLTLT
NLISLNEREE ALTTNVWIEM QWCDYRLRWD PRDYGGLWVL RVPSTMVWRP DIVLENNVDG
VFEVALYCNV LVSPDGCVYW LPPAIFRSSC PVSVTFFPFD WQNCSLIFQS QTYSTNEINL
QLSQEDGQTI EWIFIDPEAF TENGEWAIRH RPAKMLLDEA APAEEAGHQK VVFYLLIQRK
PLFYVINIIA PCVLISSVAI LIYFLPAKAG GQKCTVAINV LLAQTVFLFL VAKKVPETSQ
AVPLISKYLT FLLVVTILIV VNAVVVLNVS LRSPHTHSMA RGVRKVFLRL LPQLLRMHVR
PLAPVAVQDA HPRLQNGSSS GWPITAGEEV ALCLPRSELL FRQRQRNGLV RAALEKLEKG
PESGQSPEWC GSLKQAAPAI QACVEACNLI ARARHQQTHF DSGNKEWFLV GRVLDRVCFL
AMLSLFVCGT AGIFLMAHYN RVPALPFPGD PRSYLPSSD
