ID   CLCB_ECO7I              Reviewed;         418 AA.
AC   B7NUP7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Voltage-gated ClC-type chloride channel ClcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN   Name=clcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN   OrderedLocusNames=ECIAI39_1466;
OS   Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI39 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC       directed proton pump that is linked to amino acid decarboxylation, as
CC       part of the extreme acid resistance (XAR) response. {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01203}.
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DR   EMBL; CU928164; CAR17599.1; -; Genomic_DNA.
DR   RefSeq; YP_002407471.1; NC_011750.1.
DR   AlphaFoldDB; B7NUP7; -.
DR   SMR; B7NUP7; -.
DR   STRING; 585057.ECIAI39_1466; -.
DR   EnsemblBacteria; CAR17599; CAR17599; ECIAI39_1466.
DR   KEGG; ect:ECIAI39_1466; -.
DR   PATRIC; fig|585057.6.peg.1531; -.
DR   HOGENOM; CLU_015263_5_2_6; -.
DR   OMA; GPLTMTF; -.
DR   Proteomes; UP000000749; Chromosome.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR   HAMAP; MF_01203; CLC_ClcB; 1.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW   Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..418
FT                   /note="Voltage-gated ClC-type chloride channel ClcB"
FT                   /id="PRO_1000138681"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        178..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
SQ   SEQUENCE   418 AA;  44121 MW;  42EC5E6BCC435670 CRC64;
     MFRRLLIATV VGILAAFAVA GFRHAMLLLE WLFLNNDSGS LVNAATNLSP WRRLLTPALG
     GLAAGLLLMG WQKFTQQRPH APTDYMEALQ TDGQFDYAAS LVKSLASLLV VTSGSAIGRE
     GAMILLAALA ASCFAQCFTP RQEWKLWIAC GAAAGMAAAY RAPLAGSLFI AEVLFGTMML
     ASLGPVIISA VVALLVSNLI NHSDALLYSV QLSVTVLARD YALIISTGVL AGLCGPLLLT
     LMNACHRGFV SLKLAPPWQL ALGGLIVGLL SLFTPAVWGN GYSTVQSFLT APPLLMIIAG
     IFLCKLFAVL ASSGSGAPGG VFTPTLFIGL AIGMLYGRSL GLWFPDGEEI TLLLGLTGMA
     TLLAATTHAP IMSTLMICEM TGEYQLLPGL LIACVIASVI SRTLHRDSIY RQHTAKHS