ID   ACHG_CHICK              Reviewed;         514 AA.
AC   P02713;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Acetylcholine receptor subunit gamma;
DE   Flags: Precursor;
GN   Name=CHRNG;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6096871; DOI=10.1073/pnas.81.24.7975;
RA   Nef P., Mauron A., Stalder R., Alliod C., Ballivet M.;
RT   "Structure linkage, and sequence of the two genes encoding the delta and
RT   gamma subunits of the nicotinic acetylcholine receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:7975-7979(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ballivet M.;
RL   Submitted (OCT-1985) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
RX   PubMed=1330309; DOI=10.1007/bf00712929;
RA   Jia H.-T., Tsay H.-J., Schmidt J.;
RT   "Analysis of binding and activating functions of the chick muscle
RT   acetylcholine receptor gamma-subunit upstream sequence.";
RL   Cell. Mol. Neurobiol. 12:241-258(1992).
CC   -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC       extensive change in conformation that affects all subunits and leads to
CC       opening of an ion-conducting channel across the plasma membrane.
CC   -!- SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta,
CC       and gamma chains.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC       protein. Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; K02904; AAB59945.1; -; Genomic_DNA.
DR   EMBL; S47175; AAD13851.1; -; Genomic_DNA.
DR   PIR; A03172; ACCHG1.
DR   AlphaFoldDB; P02713; -.
DR   SMR; P02713; -.
DR   ComplexPortal; CPX-254; Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma.
DR   STRING; 9031.ENSGALP00000012818; -.
DR   PaxDb; P02713; -.
DR   VEuPathDB; HostDB:geneid_429151; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   InParanoid; P02713; -.
DR   PhylomeDB; P02713; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005892; C:acetylcholine-gated channel complex; IC:ComplexPortal.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IC:ComplexPortal.
DR   Gene3D; 1.20.58.390; -; 2.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Phosphoprotein;
KW   Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..22
FT   CHAIN           23..514
FT                   /note="Acetylcholine receptor subunit gamma"
FT                   /id="PRO_0000000337"
FT   TOPO_DOM        23..241
FT                   /note="Extracellular"
FT   TRANSMEM        242..266
FT                   /note="Helical"
FT   TRANSMEM        275..293
FT                   /note="Helical"
FT   TRANSMEM        309..330
FT                   /note="Helical"
FT   TOPO_DOM        331..473
FT                   /note="Cytoplasmic"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT   MOD_RES         386
FT                   /note="Phosphotyrosine; by Tyr-kinases"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        150..164
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   514 AA;  58926 MW;  15F87F91B436A13F CRC64;
     MRCSDLLLLF LLALCVLPGI SCRNQEEKLL QDLMTNYNRH LRPALRGDQV IDVTLKLTLT
     NLISLNEREE TLTTNVWIEM QWSDYRLRWD PDKYDDIQQL RVPSAMVWLP DIVLENNIDG
     TFEITLYTNV LVYPDGSIYW LPPAIYRSSC SIHVTYFPFD WQNCTMVFQS QTYSANEINL
     LLTVEEGQTI EWIFIDPEAF TENGEWAIKH RPARKIINSG RFTPDDIQYQ QVIFYLIIQR
     KPLFYIINII VPCVLISSMA VLVYFLPAKA GGQKCTVSIN VLLAQTVFLF LIAQKVPETS
     QAVPLIGKYL TFLMVVTVVI VVNAVIVLNV SLRTPNTHSM SQRVRQVWLH LLPRYLGMHM
     PEEAPGPPQA TRRRSSLGLM VKADEYMLWK ARTELLFEKQ KERDGLMKTV LEKIGRGLES
     NCAQDFCQSL EEASPEIRAC VEACNHIANA TREQNDFSSE NEEWILVGRV IDRVCFFIMA
     SLFVCGTIGI FLMAHFNQAP ALPFPGDPKT YLPP