ID   CLCB_SALDC              Reviewed;         417 AA.
AC   B5FHR3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Voltage-gated ClC-type chloride channel ClcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN   Name=clcB {ECO:0000255|HAMAP-Rule:MF_01203}; OrderedLocusNames=SeD_A1849;
OS   Salmonella dublin (strain CT_02021853).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=439851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT_02021853;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC       directed proton pump that is linked to amino acid decarboxylation, as
CC       part of the extreme acid resistance (XAR) response. {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01203}.
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DR   EMBL; CP001144; ACH78060.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5FHR3; -.
DR   SMR; B5FHR3; -.
DR   KEGG; sed:SeD_A1849; -.
DR   HOGENOM; CLU_015263_5_2_6; -.
DR   OMA; GPLTMTF; -.
DR   Proteomes; UP000008322; Chromosome.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR   HAMAP; MF_01203; CLC_ClcB; 1.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW   Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..417
FT                   /note="Voltage-gated ClC-type chloride channel ClcB"
FT                   /id="PRO_1000138686"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
SQ   SEQUENCE   417 AA;  44105 MW;  10446B3358C83619 CRC64;
     MFRRLLIATL IGILAALAVA AFRHAMQLLE WIFLSNDTGS LVNAAEGLSP WRRLITPALG
     GLAAGLLLWG WQKMNQQRPH APTDYMEALQ TDGQFDVGAS LVKSLASLLV VVSGSAIGRE
     GAMILLAALA ASSFARRFTP REEWKLWIAS GAAAGMAGAY HAPLAGSLFI AEILFGTLML
     ASLGPVVVSA VVALLTTHLL NGSDSLLYTV HLTVDLHARE YVMIVSTGLV AGLCGPLLMW
     LMTASHNSFL RLKLSPPWQL ALGGLIVGLL SLLTPTVWGN GYSVVQSFLL SPPLFSLIGG
     IFACKILAVL ASSGSGAPGG VFTPTLFVGL SIGMFLGRIW GFWLPGSDEI AILLGLAGMA
     TLLAATTHAP IMSTLMICEM TGEYQLLPGL LIACVVASVL SRTLRHDSIY RQHAAEH