CLCB_SALTI
ID CLCB_SALTI Reviewed; 417 AA.
AC Q8Z6Y0;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Voltage-gated ClC-type chloride channel ClcB;
GN Name=clcB; OrderedLocusNames=STY1574, t1411;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC directed proton pump that is linked to amino acid decarboxylation, as
CC part of the extreme acid resistance (XAR) response. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO69055.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD01823.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL513382; CAD01823.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014613; AAO69055.1; ALT_INIT; Genomic_DNA.
DR PIR; AF0681; AF0681.
DR RefSeq; NP_455989.3; NC_003198.1.
DR AlphaFoldDB; Q8Z6Y0; -.
DR SMR; Q8Z6Y0; -.
DR STRING; 220341.16502667; -.
DR EnsemblBacteria; AAO69055; AAO69055; t1411.
DR KEGG; stt:t1411; -.
DR KEGG; sty:STY1574; -.
DR PATRIC; fig|220341.7.peg.1583; -.
DR eggNOG; COG0038; Bacteria.
DR HOGENOM; CLU_015263_5_2_6; -.
DR OMA; GPLTMTF; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR HAMAP; MF_01203; CLC_ClcB; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; SSF81340; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..417
FT /note="Voltage-gated ClC-type chloride channel ClcB"
FT /id="PRO_0000094488"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..53
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..172
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..257
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..315
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..379
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..417
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 417 AA; 44200 MW; B43C8AD1268406AD CRC64;
MFRRLLIATL IGILAALAVA AFRHAMQLLE WIFLSNDTGS LVNAAEGLSP WRRLITPALG
GLAAGLLLWG WQKMNQQRPH APTDYMEALQ TDGQFDVGAS LVKSLASLLV VVSGSAIGRE
GAMILLAALA ASSFARRFTP REEWKLWIAS GAAAGMAGAY HAPLAGSLFI AEILFGTLML
ASLGPVVVSA VVALLTTHVL NGSDSLLYTV HLTVDLYARE YVMIVSTGLV AGLWGPLLMW
LMTASHNSFL RLKLSPPWQL ALGGLIVGLL SLLTPTVWGN GYSVVQSFLL SPPLFSLIGG
IFACKILAVL ASSGSGAPGG VFTPTLFVGL SIGMFLGRIW GFWLPGSDEI AILLGLAGMA
TLLAATTHAP IMSTLMICEM TGEYQLLPGL LIACVVASVL SRTLRHDSIY RQHAAEH
