ID   CLCB_YERP3              Reviewed;         414 AA.
AC   A7FHW4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Voltage-gated ClC-type chloride channel ClcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN   Name=clcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN   OrderedLocusNames=YpsIP31758_1867;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC       directed proton pump that is linked to amino acid decarboxylation, as
CC       part of the extreme acid resistance (XAR) response. {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01203}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01203}.
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DR   EMBL; CP000720; ABS49534.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7FHW4; -.
DR   SMR; A7FHW4; -.
DR   EnsemblBacteria; ABS49534; ABS49534; YpsIP31758_1867.
DR   KEGG; ypi:YpsIP31758_1867; -.
DR   HOGENOM; CLU_015263_5_2_6; -.
DR   OMA; GPLTMTF; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR   HAMAP; MF_01203; CLC_ClcB; 1.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW   Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..414
FT                   /note="Voltage-gated ClC-type chloride channel ClcB"
FT                   /id="PRO_1000066133"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
SQ   SEQUENCE   414 AA;  43477 MW;  3F13891FAB1D59D4 CRC64;
     MLRRLVISIM LGMVSALIVW LFHQAMLGLE WLLFSRTDGS LVAAAASITG WRRALTPALG
     GLAAGLLLWA YQRYQHRKPS APTDYMEAIE IGDGRLDVSA SLVKSLASLL VVSSGSAIGR
     EGAMVLLAAL FASVFAQRYA KPKEWKLWVA CGAAAGMASA YHAPLAGSLF IAEILFGTLM
     LASLGPVVIA AVSALLTTNL LQGGQETLYQ VQTLPSPWPV QYFLMALLGL MAGFSGPLFL
     KAMAASSHAF RSLNLLPPLQ LALGGIIVGL LSLIFPEVWG NGYSVVQSLL TTPPGVLLIG
     GILICKLLAV LASSGSGAPG GVFTPTLFVG AALGMLCGQI FSLWPVLGDN IGLLMALTGM
     ATLLAATTHA PIMAALMVCE MTGEYTLLPG LLLSCVIATT IARWLRPISV YRSH