CLCB_YERPE
ID CLCB_YERPE Reviewed; 414 AA.
AC Q8ZEB3; Q0WEQ2;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Voltage-gated ClC-type chloride channel ClcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN Name=clcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN OrderedLocusNames=YPO2270, y2112, YP_2066;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC directed proton pump that is linked to amino acid decarboxylation, as
CC part of the extreme acid resistance (XAR) response. {ECO:0000255|HAMAP-
CC Rule:MF_01203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01203}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01203}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM85675.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62278.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAL20897.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL20897.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE009952; AAM85675.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62278.1; ALT_INIT; Genomic_DNA.
DR PIR; AF0276; AF0276.
DR AlphaFoldDB; Q8ZEB3; -.
DR SMR; Q8ZEB3; -.
DR STRING; 214092.YPO2270; -.
DR PaxDb; Q8ZEB3; -.
DR EnsemblBacteria; AAM85675; AAM85675; y2112.
DR EnsemblBacteria; AAS62278; AAS62278; YP_2066.
DR KEGG; ype:YPO2270; -.
DR KEGG; ypj:CH55_361; -.
DR KEGG; ypk:y2112; -.
DR KEGG; ypl:CH46_2843; -.
DR KEGG; ypm:YP_2066; -.
DR KEGG; ypv:BZ15_1270; -.
DR KEGG; ypw:CH59_3846; -.
DR PATRIC; fig|632.151.peg.1239; -.
DR eggNOG; COG0038; Bacteria.
DR HOGENOM; CLU_015263_5_2_6; -.
DR OMA; GPLTMTF; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR HAMAP; MF_01203; CLC_ClcB; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; SSF81340; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..414
FT /note="Voltage-gated ClC-type chloride channel ClcB"
FT /id="PRO_0000094491"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
SQ SEQUENCE 414 AA; 43489 MW; 9D3E670D8AC0BBF5 CRC64;
MLRRLVISIM LGMVSALIVW LFHQAMLGLE WLLFSRTDGS LVAAAASITG WRRALTPALG
GLAAGLLLWA YQRYQHRKPS APTDYMEAIE IGDGRLDVSA SLVKSLASLL VVSSGSAIGR
EGAMVLLAAL FASVFAQRYA KPKEWKLWVA CGAAAGMASA YHAPLAGSLF IAEILFGTLM
LASLGPVVIA AVSALLTINL LQGGQETLYQ VQTLPSPWPV QYFLMALLGL MAGFSGPLFL
KAMAASSHAF RSLNLLPPLQ LALGGIIVGL LSLIFPEVWG NGYSVVQSLL TTPPGVLLIG
GILICKLLAV LASSGSGAPG GVFTPTLFVG AALGMLCGQI FSLWPVLGDN IGLLMALTGM
ATLLAATTHA PIMAALMVCE MTGEYTLLPG LLLSCVIATT IARWLRPISV YRSH
