CLCB_YERPS
ID CLCB_YERPS Reviewed; 414 AA.
AC Q9AGD5; Q66AD8; Q93AN9;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Voltage-gated ClC-type chloride channel ClcB {ECO:0000255|HAMAP-Rule:MF_01203};
GN Name=clcB {ECO:0000255|HAMAP-Rule:MF_01203}; OrderedLocusNames=YPTB2192;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=487/90 / Serotype 6, AH / Serotype 4b, and YPT1 / Serotype 3;
RX PubMed=12142419; DOI=10.1128/jb.184.16.4489-4499.2002;
RA Carnoy C., Floquet S., Marceau M., Sebbane F., Haentjens-Herwegh S.,
RA Devalckenaere A., Simonet M.;
RT "The superantigen gene ypm is located in an unstable chromosomal locus of
RT Yersinia pseudotuberculosis.";
RL J. Bacteriol. 184:4489-4499(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Probably acts as an electrical shunt for an outwardly-
CC directed proton pump that is linked to amino acid decarboxylation, as
CC part of the extreme acid resistance (XAR) response. {ECO:0000255|HAMAP-
CC Rule:MF_01203}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01203}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClcB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01203}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK28548.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL02238.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL14973.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAH21430.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF335466; AAK28548.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF414083; AAL02238.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF418982; AAL14973.1; ALT_INIT; Genomic_DNA.
DR EMBL; BX936398; CAH21430.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q9AGD5; -.
DR SMR; Q9AGD5; -.
DR EnsemblBacteria; CAH21430; CAH21430; YPTB2192.
DR KEGG; ypo:BZ17_268; -.
DR KEGG; yps:YPTB2192; -.
DR PATRIC; fig|273123.14.peg.284; -.
DR OMA; GPLTMTF; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0010447; P:response to acidic pH; IEA:InterPro.
DR HAMAP; MF_01203; CLC_ClcB; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR023790; Cl-channel_volt-gated_ClcB.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; SSF81340; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chloride; Chloride channel;
KW Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..414
FT /note="Voltage-gated ClC-type chloride channel ClcB"
FT /id="PRO_0000094492"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01203"
FT VARIANT 6
FT /note="V -> L (in strain: 487/90)"
FT VARIANT 66
FT /note="L -> S (in strain: 487/90)"
FT VARIANT 134
FT /note="V -> I (in strain: 487/90)"
FT VARIANT 141
FT /note="K -> N (in strain: 487/90)"
FT VARIANT 207
FT /note="T -> P (in strain: 487/90)"
FT VARIANT 213
FT /note="T -> A (in strain: 487/90)"
FT VARIANT 242
FT /note="A -> S (in strain: 487/90)"
FT VARIANT 256
FT /note="L -> S (in strain: 487/90)"
FT VARIANT 266
FT /note="I -> V (in strain: 487/90)"
FT VARIANT 304
FT /note="I -> V (in strain: 487/90)"
FT VARIANT 342
FT /note="S -> A (in strain: 487/90)"
FT VARIANT 406
FT /note="R -> H (in strain: 487/90)"
SQ SEQUENCE 414 AA; 43477 MW; 3F13891FAB1D59D4 CRC64;
MLRRLVISIM LGMVSALIVW LFHQAMLGLE WLLFSRTDGS LVAAAASITG WRRALTPALG
GLAAGLLLWA YQRYQHRKPS APTDYMEAIE IGDGRLDVSA SLVKSLASLL VVSSGSAIGR
EGAMVLLAAL FASVFAQRYA KPKEWKLWVA CGAAAGMASA YHAPLAGSLF IAEILFGTLM
LASLGPVVIA AVSALLTTNL LQGGQETLYQ VQTLPSPWPV QYFLMALLGL MAGFSGPLFL
KAMAASSHAF RSLNLLPPLQ LALGGIIVGL LSLIFPEVWG NGYSVVQSLL TTPPGVLLIG
GILICKLLAV LASSGSGAPG GVFTPTLFVG AALGMLCGQI FSLWPVLGDN IGLLMALTGM
ATLLAATTHA PIMAALMVCE MTGEYTLLPG LLLSCVIATT IARWLRPISV YRSH
