CLCC_DICDI
ID CLCC_DICDI Reviewed; 757 AA.
AC Q75JF3; Q552G7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Chloride channel protein C;
GN Name=clcC; ORFNames=DDB_G0276229;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC several functions including the regulation of cell volume, membrane
CC potential stabilization and signal transduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69414.1; -; Genomic_DNA.
DR RefSeq; XP_643243.1; XM_638151.1.
DR AlphaFoldDB; Q75JF3; -.
DR SMR; Q75JF3; -.
DR STRING; 44689.DDB0233304; -.
DR PaxDb; Q75JF3; -.
DR EnsemblProtists; EAL69414; EAL69414; DDB_G0276229.
DR GeneID; 8620286; -.
DR KEGG; ddi:DDB_G0276229; -.
DR dictyBase; DDB_G0276229; clcC.
DR eggNOG; KOG0474; Eukaryota.
DR HOGENOM; CLU_003181_4_1_1; -.
DR InParanoid; Q75JF3; -.
DR OMA; YWAGFLY; -.
DR PhylomeDB; Q75JF3; -.
DR PRO; PR:Q75JF3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF81340; SSF81340; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..757
FT /note="Chloride channel protein C"
FT /id="PRO_0000328045"
FT TOPO_DOM 1..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 600..667
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 710..757
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ SEQUENCE 757 AA; 85415 MW; 5C353B22B2A75C0D CRC64;
MGSSLNKPLS DRVEDINNQS SMIYDPWRHR GDVNSTYHSS SSVTHRRRNH RLSPLEKQKM
KNIQSLNFSV NDNLLQREEY EKTTKGLHLK KTFGKWIICL FLGVIVGCIA YVIKMVVQLL
QGLKFHYTNH YVSNGLQGEA FLTFLGINLL FVFLSCLMVI VAGPLASSSG IPEVKGILNG
VKVREALGFR ALLGKIVSLV LSFSSGLFVG PEGPMIHIGS AVGAAISQFK SSTMGFYPSL
FLSYRNDRDK RDFISIGAAT GLAAAFGAPI GGVLFSIEEV SSFWSRQLTW RTFFTCVIAA
FTTNFLLQGI GSSPDMHDTG LLTFGFSRLY LFRYSELLCF CFLGLIGGLL GAFFVFLNIH
LNKWRKEKLK QNPYLRLFEA LFVSVVTSVV CYYASFIFDC RYQSNIVIET SVCEDQSNTE
MVQFFCPDGM YSELGSLLFG NPDQALRRLY SRTNNMFTLP PLLVFTLISL FFSIWSSGLW
VAGGLFVPMM MVGAGFGRLF GQTISMWFTN IDSSIYALVG SAAMMAGYCR MTVCIVVIMV
ELTEGTQYLV PIILAVMISK WVGDFFNESV YEHLMEQKSI PFLQSKPPHS TNNIRISDVM
SKNVVVLPEV CQVRLLVNIL NSNNHNAFPV INSGPYDNQR LYRGIILRDH ILVLLFYRVF
YRGTGEEIYL DENFDFDKFT TETSKSPPPL SEMNFDQFEL DSFIDLRPYM NSSGVTIHNT
FSFVEAYKLF RNMGLRHLPV IDINNEVVGM VTRNDLF
