CLCE_DICDI
ID CLCE_DICDI Reviewed; 994 AA.
AC Q54LQ4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Chloride channel protein E;
GN Name=clcE; ORFNames=DDB_G0286491;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC several functions including the regulation of cell volume, membrane
CC potential stabilization and signal transduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000086; EAL64196.1; -; Genomic_DNA.
DR RefSeq; XP_637702.1; XM_632610.1.
DR AlphaFoldDB; Q54LQ4; -.
DR SMR; Q54LQ4; -.
DR STRING; 44689.DDB0233306; -.
DR PaxDb; Q54LQ4; -.
DR EnsemblProtists; EAL64196; EAL64196; DDB_G0286491.
DR GeneID; 8625644; -.
DR KEGG; ddi:DDB_G0286491; -.
DR dictyBase; DDB_G0286491; clcE.
DR eggNOG; KOG0476; Eukaryota.
DR HOGENOM; CLU_300996_0_0_1; -.
DR InParanoid; Q54LQ4; -.
DR OMA; YKIHSIF; -.
DR PhylomeDB; Q54LQ4; -.
DR Reactome; R-DDI-2672351; Stimuli-sensing channels.
DR PRO; PR:Q54LQ4; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF81340; SSF81340; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..994
FT /note="Chloride channel protein E"
FT /id="PRO_0000328047"
FT TOPO_DOM 1..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 644..705
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 944..994
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 110302 MW; 9DE0EE43EFB7896C CRC64;
MTRKENEESE SLSSSSSPID NSNNNNNNNN HSIFNPIGHI QNAFNNIDLN PLNVDFKGHT
DKVVNFFQHG TGDLNDRMQG VVSKLRSNEY RKKMHSVLTK IKDTKEYKST SNTDYDVIFE
SVDMYSNLQQ DPTMDKDEID VVTDLSSYKK KFTHWLGKER ISTLLFIPTL GILIALMGIL
CDFLLMELGT LRDFVTSRHN SHVIPTDGTT PTPNSSIADK YDLVEGIVFV GYSVFFALIS
VCCISFISPY AVGSGIPEMK SIMSGINLSR VLGFKTLVSK IVGMVCASAA GLTIGRTGPF
MHASAIISQM LMNLKVFGAI KKNQIVRYQM LICALTSGVV ANFGAPIGGL LFAIEVTATT
AVMGNLWKGF LCATTTAIIF FLSRSTFSKG NFHSVYEFEF VPKEYGVADL ITFVGIGIIT
GLIGAFFVFI YEKLVRFRLR YPILKQSRII LVLVVSLFSA IITYSAGPLC RVSLPTAMKQ
FLGQNEPKPF LFEQDQTPYY KYLNLLVFIV VKLILTAFNI VLPIPGGAIT PFIVTGAALG
RLFGEILKDH FDSQAIEPAG FAAIASAGLV SGTIRNISPS IFVLELTGQL SLLVPILICS
ITSTAVGNFF NRPLFDTALK IQGLPFLSNY RSSKVYTMTA KQVMKKNINY LSMTSTVIEM
KNFLDTFKYT FIPIVDSKEN MLLVGIVERS SMIYMLDIHI ENIEQKIDEF KSKYFVNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NSNNSENLEI ENTGAILNTN
SNNNNSDEED YDRKDNDKIS LIKPNQDESS SNSNGGSSSD FEEILNTQNT NINKNDNEDL
IKEIEDENSS LGEKPIIEHD DEDDDEEEGD GIPLVSMKDQ QPVLRNRHTT TTTTTTTTTP
ITENIYVNDA FEISINDLKN GGQSVWGKHI LGDIIHSGET ALLMDLAPSQ VPDLTPLNKV
FHLFTMLGLG FTYVTSLGKL VGVITKNSLM EQDL
