ID   CLCE_PSEKB              Reviewed;         352 AA.
AC   O30847;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Maleylacetate reductase;
DE            EC=1.3.1.32;
GN   Name=clcE;
OS   Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1301098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9171435; DOI=10.1128/jb.179.11.3801-3803.1997;
RA   Kasberg T., Seibert V., Schlomann M., Reineke W.;
RT   "Cloning, characterization, and sequence analysis of the clcE gene encoding
RT   the maleylacetate reductase of Pseudomonas sp. strain B13.";
RL   J. Bacteriol. 179:3801-3803(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH;
CC         Xref=Rhea:RHEA:16981, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.32;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH;
CC         Xref=Rhea:RHEA:16985, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.32;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-chlorocatechol degradation.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; AF019038; AAB71540.1; -; Genomic_DNA.
DR   RefSeq; WP_011489357.1; NZ_HG322950.1.
DR   AlphaFoldDB; O30847; -.
DR   SMR; O30847; -.
DR   STRING; 1301098.PKB_3277; -.
DR   eggNOG; COG1454; Bacteria.
DR   OMA; CGRSMAR; -.
DR   OrthoDB; 1456634at2; -.
DR   BioCyc; MetaCyc:MON-14383; -.
DR   UniPathway; UPA00083; -.
DR   GO; GO:0018506; F:maleylacetate reductase activity; IDA:CACAO.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08177; MAR; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR034786; MAR.
DR   PANTHER; PTHR11496; PTHR11496; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN           1..352
FT                   /note="Maleylacetate reductase"
FT                   /id="PRO_0000087846"
SQ   SEQUENCE   352 AA;  37769 MW;  D4DBFDD69D990E79 CRC64;
     MNFIHDYRSP RVIFGPDSLA RLPQELERLG IDRALVLTTP EQAPLGRQVA EPVIGHVAAF
     YDGATMHVPA LVAEEACKIA RTSEANGVIA IGGGSTIGLA KIVALRTELP IVAVPTTYAG
     SEMTSIFGIT EGGVKKTGRD ARVMPRAVIY EPRLTLELPL SISVTSAINA IAHAVEGLYA
     PDATPLLTIM AQEGIAATVR AISRMYQSPR DLQARGDALY GAWLCASVLG NVSMALHHKL
     CHTLGGTLDL PHAQTHTVVL PHALAYNARA VPDAMRVLRI ALGHDDPPTA LYELARDNGA
     PVALRDLGMR EEDIEHVGDL ALQDRYPNPR ELDRDALLAL LRDAYHGRPP SA