CLCF_DICDI
ID CLCF_DICDI Reviewed; 809 AA.
AC Q54C67;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Chloride channel protein F;
GN Name=clcF; ORFNames=DDB_G0293130;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Voltage-gated chloride channel. Chloride channels may have
CC several functions including the regulation of cell volume, membrane
CC potential stabilization and signal transduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000199; EAL60917.1; -; Genomic_DNA.
DR RefSeq; XP_629352.1; XM_629350.1.
DR AlphaFoldDB; Q54C67; -.
DR SMR; Q54C67; -.
DR STRING; 44689.DDB0233307; -.
DR PaxDb; Q54C67; -.
DR EnsemblProtists; EAL60917; EAL60917; DDB_G0293130.
DR GeneID; 8629076; -.
DR KEGG; ddi:DDB_G0293130; -.
DR dictyBase; DDB_G0293130; clcF.
DR eggNOG; KOG0476; Eukaryota.
DR HOGENOM; CLU_006904_2_0_1; -.
DR InParanoid; Q54C67; -.
DR OMA; EAQKWMH; -.
DR PhylomeDB; Q54C67; -.
DR Reactome; R-DDI-2672351; Stimuli-sensing channels.
DR PRO; PR:Q54C67; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF81340; SSF81340; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..809
FT /note="Chloride channel protein F"
FT /id="PRO_0000328048"
FT TOPO_DOM 1..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 539..597
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 756..809
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 604..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 89427 MW; 3D30D340562465A2 CRC64;
MSTSKYSKMI SSKHGYKKTR IKNNTSDSDL FNLVMPKADV VGFKSKQGGI SRQAISWAKF
ARLNNFYIWL FLAAVGLLGS IYLVAVDLIF KYVVFSWREA FMSLTENYFL QYLSFIAWTV
ALATGSCFII KKICPAAVGS GIPDLKSIFS GFWNPFVVAP MVLLWKTIGL LLSYGSGLSI
GKEGPYIHIS ATLANTLLSI KPFKSIAQND TQRSQLLAAC CALGVAATFG SPIGGVLFSI
EATGTFYLIS NYWRAFFTAT VGAVGIKILL SNPSNDLLES FRTHFADLNL ASAQLIAFII
LGVLCGLLAS LFISLYTKIY NWKKHNAELF KKITPFGEVI IVAAATAILS FPLKFLRLDH
ATAVHTMFTA TPDSDNSEVL SELAVWTDSM PFNHGIILAC FLYVVVKLVL TAVSITLPIP
YGIYIPLFAI GSAVGRFVGE LMLVLFPNSK EIYPTGYAVV GAAALCGGAT RTVSSAMIIL
ELTNDLTYMV PVLLGVVLSC GIGNLLNHSI YDCFLKNKNL PYLPFYKAKS DSLIARDVMK
RDLYYVCQNT TLSQISNLLK RVDEHSIPVV SSDNDLQLIG TISTTTLEEV IAYHERLHSY
SKSPLSLSDN GIDINDNDNN DNINNNQNNN NNNNNNNNNN NSNNQNNSLV SEAIEMNVLS
DSDNDENNNL IPNIPINDNN IIIQNNIRNN NNNNFSDNNN NYNNNNYNNN NNNNNDNNTN
NDNNINNNSN DINESISEET TIDLVQMELQ NPWVVIDSSP FQIQETMPVR KIVFMFMMLG
GNILYVTNKG KLTGVVAKTE LVHQNNNKH
