ID   CLCNX_USTMA             Reviewed;        1131 AA.
AC   P0C197; A0A0D1DXR2; Q4P8S3;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Probable chloride channel protein UM03490-D;
GN   ORFNames=UMAG_11084;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-gated chloride channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000305}.
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DR   EMBL; CM003148; KIS68396.1; -; Genomic_DNA.
DR   RefSeq; XP_011390091.1; XM_011391789.1.
DR   AlphaFoldDB; P0C197; -.
DR   SMR; P0C197; -.
DR   STRING; 5270.UM03490P0; -.
DR   PRIDE; P0C197; -.
DR   EnsemblFungi; KIS68396; KIS68396; UMAG_11084.
DR   GeneID; 23567013; -.
DR   KEGG; uma:UMAG_11084; -.
DR   VEuPathDB; FungiDB:UMAG_11084; -.
DR   eggNOG; KOG0415; Eukaryota.
DR   eggNOG; KOG0475; Eukaryota.
DR   eggNOG; KOG0590; Eukaryota.
DR   eggNOG; KOG2210; Eukaryota.
DR   InParanoid; P0C197; -.
DR   OrthoDB; 271925at2759; -.
DR   Proteomes; UP000000561; Chromosome 9.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0000324; C:fungal-type vacuole; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF81340; SSF81340; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   Chloride; Chloride channel; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1131
FT                   /note="Probable chloride channel protein UM03490-D"
FT                   /id="PRO_0000232936"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        577..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        603..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        643..663
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        680..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          944..1000
FT                   /note="CBS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          815..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1061..1131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        820..835
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        858..883
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        884..901
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1081..1099
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1102..1120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1131 AA;  120695 MW;  4EC300BA7D7413E6 CRC64;
     MNASPHSKPS AALAPSPTAA FFPSTSRVYT SKAATVVDDD EALDEIRRYE SFSTVDWVVD
     NTRERNRLAR ERQAASAHFV SSSSNAHLGN ADAAWGHIGF GRGGVPPRWW SRGPWGRRAW
     LVWGIVKSAS SAFTDSGVIV LVGILIGLNM GVISLATEWA SDLKQGYCSS GWWLNQKFCC
     WEMMDQAGPG GAPLPAAAKA LATATVTVTA SIGAAAAATD SAPILPATPA ATPTAAIRAV
     AQEAYNLTIR AIPDHQLWSR SAQDVIQDGF GTGLRLLSRA EGAASGAGDL SETCTDWVRW
     SKWSFPAWII YMLFAGLLSF ICAHLVKSFA PYAAGSGISE IKCILAGFVI NGYLGFWTLA
     IKSLTLPLAI ASGLSVGKEG PAVHVACCIG NVVASFFRSF NRSQAKMREL LTASSAAGVA
     VAFGSPIGGV LFSLEEMAYN FPASTMWRSF LCALAATVTL SFMNPFRTGK LVLFQVSYDR
     DWHYFEIMFY ILIGIFGGLY GAFVIKYNLQ VQSFRRSYLV KHGVSEVVVL ATLTAFVGYA
     NKFLRIDMTE SLEILFRECE GGGDYDNLCQ SWAQWRMVNS LLLATVLRTA LVIVSYGCKV
     PAGIFVPSMA IGATFGRMVG ILVKALYNAF PHWSLFSACQ PDVPCITPGT YAFLGAAAAL
     AGVTRITVAV VVIMFELTGA LTYILPTMIV VGITKGVADW FSRGGIAEQM IKFSGYPFLD
     KDDHNFGIPV ADVMRVCPQV LFASGMKLSE LEGKLADGSY KGFPLVLAKH DATLLGYVGK
     VELRYAIGKA RRARALDGDT LCLFSVGPNA LDRADGVESS AHGAQQQQPD LLSVASLPTT
     AAADRAVRED MLSRFSGATG AGSASGLGST SATGVASQRR HESESLIGQL DVEDDRSSAP
     SYRSRVDAGD NMSSSSDDDA VVGNAGGGVD GESDLDKLEL GGWIDPTPLI VQPGMPLETV
     MDMFKNLGPR VILVVEYGRL SGLVTVKDVL KRIAMQEKAE AAARTAAAAG LPMSGSANSF
     TGEGAGAGGG ELEALLKEAY EWAQEKWALI SPRIERISAR RASASRGGAP GSQAGQARYS
     HLRESTEDRY DDSDAVAEDM PMHSTRQTSA TKNTRSEHHQ FVLGAQDDDD E