ID   CLCR_PSEPU              Reviewed;         294 AA.
AC   Q05840;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator ClcR;
DE   AltName: Full=ClcABD operon transcriptional activator;
GN   Name=clcR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid pDC15.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAC27;
RX   PubMed=8419291; DOI=10.1128/jb.175.2.417-427.1993;
RA   Coco W.M., Rothmel R.K., Henikoff S., Chakrabarty A.M.;
RT   "Nucleotide sequence and initial functional characterization of the clcR
RT   gene encoding a LysR family activator of the clcABD chlorocatechol operon
RT   in Pseudomonas putida.";
RL   J. Bacteriol. 175:417-427(1993).
CC   -!- FUNCTION: Involved in regulation of chlorinated catechol metabolism.
CC       Transcriptional activator of the clcABD chlorocatechol oxidative
CC       operon.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L06464; AAA25771.1; -; Genomic_DNA.
DR   PIR; A40641; A40641.
DR   AlphaFoldDB; Q05840; -.
DR   SMR; Q05840; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08485; PBP2_ClcR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037421; ClcR_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Aromatic hydrocarbons catabolism; Cytoplasm; DNA-binding;
KW   Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..294
FT                   /note="HTH-type transcriptional regulator ClcR"
FT                   /id="PRO_0000105611"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   294 AA;  32528 MW;  8F6345BF8A11ABE3 CRC64;
     MEFRQLRYFI AVAEEGNIGA AARRLHISQP PITRQIQALE QDLGVVLFER THRGVELTAA
     GTTFLEDARR LLHVTEISRV RSRAASRGEI GELRVAYFGT VVLHTLPLLL RQLLSVAPSA
     TVSLTQMSKN RQIEALDAGT IDIGFGRFYP YQEGVVVRNV TNERLFLGAQ KSRARSFGEQ
     VHCSALRNEP FILFPREGRP SFADEVIGVF KNARVEPKVV AIVEDVNAAM ALALAGVGVT
     IVPETVAMIS WPDFGFTELV GSKATVPVSC IYRHDHIAPI LKTFLNLLPI RESQ