ID   CLD11_PONAB             Reviewed;         200 AA.
AC   Q5REK8;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Claudin-11;
GN   Name=CLDN11;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with tetraspanin-3/TSPAN3. Interacts with OCLN.
CC       {ECO:0000250|UniProtKB:O75508, ECO:0000250|UniProtKB:Q60771}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250|UniProtKB:O75508}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; CR857517; CAH89799.1; -; mRNA.
DR   AlphaFoldDB; Q5REK8; -.
DR   SMR; Q5REK8; -.
DR   STRING; 9601.ENSPPYP00000015975; -.
DR   eggNOG; ENOG502QSDJ; Eukaryota.
DR   InParanoid; Q5REK8; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003555; Claudin11.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   PANTHER; PTHR12002:SF6; PTHR12002:SF6; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01384; CLAUDIN11.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Phosphoprotein; Reference proteome;
KW   Tight junction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..200
FT                   /note="Claudin-11"
FT                   /id="PRO_0000144763"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..115
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..150
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         190
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q60771"
FT   MOD_RES         191
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q60771"
SQ   SEQUENCE   200 AA;  21248 MW;  ED89F1B2127A0029 CRC64;
     MVATCLQVVG FVTSFVGWIG VIVTTSTNDW VVTCGYTIPT CRKLDELGSK GLWADCVMAT
     GLYHCKPLVD ILPCRALMIA ASVLGLPAIL LLLTVLPCIR MGQEPGVAKY RRAQLAGVLL
     ILLALCAIVA TIWFPVCAHR ETTIVSFGYS LYAGWIGAVL CLVGGCVILC CAGDAQAFGE
     NRFYYTAGSS SPTHAKSAHV