CLD12_BOVIN
ID CLD12_BOVIN Reviewed; 244 AA.
AC Q0IIL2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Claudin-12;
GN Name=CLDN12;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with OCLN. {ECO:0000250|UniProtKB:P56749}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250|UniProtKB:P56749}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; BC122589; AAI22590.1; -; mRNA.
DR RefSeq; NP_001069591.1; NM_001076123.1.
DR AlphaFoldDB; Q0IIL2; -.
DR SMR; Q0IIL2; -.
DR STRING; 9913.ENSBTAP00000025950; -.
DR PaxDb; Q0IIL2; -.
DR Ensembl; ENSBTAT00000025950; ENSBTAP00000025950; ENSBTAG00000019486.
DR GeneID; 538709; -.
DR KEGG; bta:538709; -.
DR CTD; 9069; -.
DR VEuPathDB; HostDB:ENSBTAG00000019486; -.
DR VGNC; VGNC:27404; CLDN12.
DR eggNOG; ENOG502QR4G; Eukaryota.
DR GeneTree; ENSGT00400000022250; -.
DR HOGENOM; CLU_063070_0_0_1; -.
DR InParanoid; Q0IIL2; -.
DR OMA; FYNTHLN; -.
DR OrthoDB; 933771at2759; -.
DR TreeFam; TF331972; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000019486; Expressed in oocyte and 104 other tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR013287; Claudin12.
DR InterPro; IPR017974; Claudin_CS.
DR PANTHER; PTHR16703; PTHR16703; 1.
DR PRINTS; PR01872; CLAUDIN12.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Membrane; Phosphoprotein; Reference proteome;
KW Tight junction; Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Claudin-12"
FT /id="PRO_0000273421"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 228
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56749"
FT MOD_RES 231
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56749"
SQ SEQUENCE 244 AA; 26951 MW; 53BC7978700B93A8 CRC64;
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV YTGLWVKCAR
YDGGNDCLMY DAAWYSSVDQ LDLRVLQFAL PLSILIAMGA LLLCLIGMCN TAFRSSVPNI
KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP SIWVIFYNIH LNRKFEPVFA FDYAVYVTVA
SAGGLFMTAL LLFIWYCACK SLPSPFWQPL YSHPPGMHTY SQPYSARSRL SAIEIDIPVV
SHTT
