ID   CLD12_PONAB             Reviewed;         244 AA.
AC   Q5R9K1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Claudin-12;
GN   Name=CLDN12;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with OCLN. {ECO:0000250|UniProtKB:P56749}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250|UniProtKB:P56749}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; CR859386; CAH91559.1; -; mRNA.
DR   RefSeq; NP_001127432.1; NM_001133960.1.
DR   RefSeq; XP_009241309.1; XM_009243034.1.
DR   AlphaFoldDB; Q5R9K1; -.
DR   STRING; 9601.ENSPPYP00000019983; -.
DR   Ensembl; ENSPPYT00000020771; ENSPPYP00000019983; ENSPPYG00000017829.
DR   GeneID; 100174503; -.
DR   KEGG; pon:100174503; -.
DR   CTD; 9069; -.
DR   eggNOG; ENOG502QR4G; Eukaryota.
DR   GeneTree; ENSGT00400000022250; -.
DR   HOGENOM; CLU_063070_0_0_1; -.
DR   InParanoid; Q5R9K1; -.
DR   OMA; FYNTHLN; -.
DR   OrthoDB; 933771at2759; -.
DR   TreeFam; TF331972; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   InterPro; IPR013287; Claudin12.
DR   InterPro; IPR017974; Claudin_CS.
DR   PANTHER; PTHR16703; PTHR16703; 1.
DR   PRINTS; PR01872; CLAUDIN12.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Phosphoprotein; Reference proteome;
KW   Tight junction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..244
FT                   /note="Claudin-12"
FT                   /id="PRO_0000144767"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..87
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..174
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         228
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56749"
FT   MOD_RES         231
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56749"
SQ   SEQUENCE   244 AA;  27110 MW;  0547A9D76392CB5F CRC64;
     MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV YTGLWVKCAR
     YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA LLLCLIGMCN TAFRSSVPNI
     KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA
     SAGGLFMTSL ILFIWYCTCK SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV
     SHTT