CLD17_PIG
ID CLD17_PIG Reviewed; 225 AA.
AC C3VMW3;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Claudin-17;
GN Name=CLDN17;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Xie J.-X., Wang Y.-L., Yang G.-Y., Wang W.-J., Zhang Z.-Q., Chen F.-W.,
RA Li W.-L., Chang L., Yan W., Sun Y.-L., Gao J.-W., Niu H., Wu Y.-X.,
RA Wang J., Zang M.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc;
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=22402829; DOI=10.1007/s00018-012-0949-x;
RA Krug S.M., Guenzel D., Conrad M.P., Rosenthal R., Fromm A., Amasheh S.,
RA Schulzke J.D., Fromm M.;
RT "Claudin-17 forms tight junction channels with distinct anion
RT selectivity.";
RL Cell. Mol. Life Sci. 69:2765-2778(2012).
CC -!- FUNCTION: Channel-forming tight junction protein with selectivity for
CC anions, including chloride and bicarbonate, and for solutes smaller
CC than 9 Angstrom in diameter. In the kidney proximal tubule, may be
CC involved in quantitative reabsorption of filtered anions. Does not
CC affect water permeability. {ECO:0000269|PubMed:22402829}.
CC -!- SUBUNIT: Interacts with OCLN. {ECO:0000250|UniProtKB:P56750}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000250|UniProtKB:P56750}. Cell membrane
CC {ECO:0000250|UniProtKB:P56750}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P56750}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; FJ875102; ACP19320.1; -; mRNA.
DR EMBL; CU855716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001153555.1; NM_001160083.1.
DR AlphaFoldDB; C3VMW3; -.
DR SMR; C3VMW3; -.
DR STRING; 9823.ENSSSCP00000012813; -.
DR PaxDb; C3VMW3; -.
DR Ensembl; ENSSSCT00000013163; ENSSSCP00000012813; ENSSSCG00000012031.
DR Ensembl; ENSSSCT00035105358; ENSSSCP00035045236; ENSSSCG00035077377.
DR Ensembl; ENSSSCT00045003004; ENSSSCP00045001895; ENSSSCG00045001927.
DR Ensembl; ENSSSCT00055031144; ENSSSCP00055024800; ENSSSCG00055015813.
DR Ensembl; ENSSSCT00065067091; ENSSSCP00065029147; ENSSSCG00065049022.
DR GeneID; 100294681; -.
DR KEGG; ssc:100294681; -.
DR CTD; 26285; -.
DR VGNC; VGNC:86734; CLDN17.
DR eggNOG; ENOG502RTNJ; Eukaryota.
DR GeneTree; ENSGT00940000162550; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; C3VMW3; -.
DR OMA; VCWTANI; -.
DR OrthoDB; 1314055at2759; -.
DR TreeFam; TF331936; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000012031; Expressed in tonsil and 1 other tissue.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Chloride; Chloride channel; Ion channel;
KW Ion transport; Membrane; Reference proteome; Tight junction; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..225
FT /note="Claudin-17"
FT /id="PRO_0000437543"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..164
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 194..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 225 AA; 24747 MW; 851EC84AF1E83983 CRC64;
MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFIGSNI IVFERIWEGL WMNCVRQAKA
RLQCKFYSSM LALSPALEAA RALMCVAVAL SLIALIIGIC GMKKIQCTGS NERAKAYLLG
TSGVLFILTG IFVLIPVCWT ANIIIRDFYN PAVHVGQKRE LGAALFLGWA SVAVLFIAGG
LLCGFCCCNR KKQRDGYPAP RPSMPRTDER RRNMTRQSET PTSYV