CLD19_RAT
ID CLD19_RAT Reviewed; 224 AA.
AC Q5QT56; Q6AY67;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Claudin-19;
GN Name=Cldn19;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Wistar;
RA Morita K.;
RT "Rat claudin-19.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250|UniProtKB:Q9ET38}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane;
CC Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5QT56-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5QT56-2; Sequence=VSP_013231;
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AF497645; AAQ07257.1; -; mRNA.
DR EMBL; BC079172; AAH79172.1; -; mRNA.
DR RefSeq; NP_001008514.1; NM_001008514.1. [Q5QT56-2]
DR RefSeq; XP_006238818.1; XM_006238756.3. [Q5QT56-1]
DR AlphaFoldDB; Q5QT56; -.
DR SMR; Q5QT56; -.
DR STRING; 10116.ENSRNOP00000050261; -.
DR iPTMnet; Q5QT56; -.
DR PhosphoSitePlus; Q5QT56; -.
DR PaxDb; Q5QT56; -.
DR Ensembl; ENSRNOT00000047151; ENSRNOP00000050261; ENSRNOG00000007922. [Q5QT56-1]
DR Ensembl; ENSRNOT00000113733; ENSRNOP00000080206; ENSRNOG00000007922. [Q5QT56-2]
DR GeneID; 298487; -.
DR KEGG; rno:298487; -.
DR UCSC; RGD:1305000; rat. [Q5QT56-1]
DR CTD; 149461; -.
DR RGD; 1305000; Cldn19.
DR eggNOG; ENOG502QTG5; Eukaryota.
DR GeneTree; ENSGT00940000158624; -.
DR HOGENOM; CLU_076370_2_0_1; -.
DR InParanoid; Q5QT56; -.
DR OMA; ARFEFGP; -.
DR OrthoDB; 1244077at2759; -.
DR PhylomeDB; Q5QT56; -.
DR TreeFam; TF331936; -.
DR PRO; PR:Q5QT56; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000007922; Expressed in adult mammalian kidney and 6 other tissues.
DR Genevisible; Q5QT56; RN.
DR GO; GO:0043296; C:apical junction complex; ISO:RGD.
DR GO; GO:0016323; C:basolateral plasma membrane; ISO:RGD.
DR GO; GO:0005923; C:bicellular tight junction; ISO:RGD.
DR GO; GO:0030054; C:cell junction; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; ISO:RGD.
DR GO; GO:0043297; P:apical junction assembly; ISO:RGD.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0061045; P:negative regulation of wound healing; ISO:RGD.
DR GO; GO:0019227; P:neuronal action potential propagation; ISO:RGD.
DR GO; GO:1901890; P:positive regulation of cell junction assembly; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0150111; P:regulation of transepithelial transport; ISO:RGD.
DR GO; GO:0120193; P:tight junction organization; ISO:RGD.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell junction; Cell membrane; Disulfide bond;
KW Membrane; Reference proteome; Tight junction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..224
FT /note="Claudin-19"
FT /id="PRO_0000144783"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 54..64
FT /evidence="ECO:0000250|UniProtKB:Q9ET38"
FT VAR_SEQ 210..224
FT /note="PVVKLSTSVKGPLGV -> YV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013231"
SQ SEQUENCE 224 AA; 23315 MW; 3EF6B164D499A883 CRC64;
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL WMSCASQSTG
QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV GMKCTRVGDS NPTAKGRVAI
SGGALFLLAG LCTLTAVSWY ATLVTQEFFN PSTPVNARYE FGPALFVGWA SAGLAILGGS
FLCCTCPEPE RANSIPQPYR SGPSTAAREP VVKLSTSVKG PLGV
