CLD20_HUMAN
ID CLD20_HUMAN Reviewed; 219 AA.
AC P56880;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Claudin-20;
GN Name=CLDN20;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RA Keen T.J.;
RL Unpublished observations (FEB-2000).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- INTERACTION:
CC P56880; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-23801559, EBI-12109402;
CC P56880; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-23801559, EBI-12208021;
CC P56880; P24593: IGFBP5; NbExp=3; IntAct=EBI-23801559, EBI-720480;
CC P56880; P21145: MAL; NbExp=3; IntAct=EBI-23801559, EBI-3932027;
CC P56880; P60201-2: PLP1; NbExp=3; IntAct=EBI-23801559, EBI-12188331;
CC P56880; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-23801559, EBI-11528917;
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane;
CC Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AL139101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020838; AAH20838.1; -; mRNA.
DR CCDS; CCDS5249.1; -.
DR RefSeq; NP_001001346.1; NM_001001346.3.
DR RefSeq; XP_011534150.1; XM_011535848.2.
DR AlphaFoldDB; P56880; -.
DR SMR; P56880; -.
DR BioGRID; 119070; 10.
DR IntAct; P56880; 6.
DR STRING; 9606.ENSP00000356133; -.
DR BioMuta; CLDN20; -.
DR DMDM; 7387580; -.
DR PaxDb; P56880; -.
DR PeptideAtlas; P56880; -.
DR PRIDE; P56880; -.
DR Antibodypedia; 33420; 96 antibodies from 19 providers.
DR DNASU; 49861; -.
DR Ensembl; ENST00000367165.3; ENSP00000356133.3; ENSG00000171217.5.
DR GeneID; 49861; -.
DR KEGG; hsa:49861; -.
DR MANE-Select; ENST00000367165.3; ENSP00000356133.3; NM_001001346.3; NP_001001346.1.
DR UCSC; uc003qql.2; human.
DR CTD; 49861; -.
DR GeneCards; CLDN20; -.
DR HGNC; HGNC:2042; CLDN20.
DR HPA; ENSG00000171217; Low tissue specificity.
DR neXtProt; NX_P56880; -.
DR OpenTargets; ENSG00000171217; -.
DR PharmGKB; PA26568; -.
DR VEuPathDB; HostDB:ENSG00000171217; -.
DR eggNOG; ENOG502QYUE; Eukaryota.
DR GeneTree; ENSGT00940000161252; -.
DR HOGENOM; CLU_076370_1_1_1; -.
DR InParanoid; P56880; -.
DR OMA; GMKCTHL; -.
DR OrthoDB; 1137602at2759; -.
DR PhylomeDB; P56880; -.
DR TreeFam; TF331936; -.
DR PathwayCommons; P56880; -.
DR Reactome; R-HSA-420029; Tight junction interactions.
DR SignaLink; P56880; -.
DR BioGRID-ORCS; 49861; 11 hits in 1059 CRISPR screens.
DR GeneWiki; CLDN20; -.
DR GenomeRNAi; 49861; -.
DR Pharos; P56880; Tdark.
DR PRO; PR:P56880; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P56880; protein.
DR Bgee; ENSG00000171217; Expressed in buccal mucosa cell and 98 other tissues.
DR ExpressionAtlas; P56880; baseline and differential.
DR Genevisible; P56880; HS.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070160; C:tight junction; IDA:ARUK-UCL.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..219
FT /note="Claudin-20"
FT /id="PRO_0000144784"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 193..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 219 AA; 23515 MW; D2F5FAD2AAB66306 CRC64;
MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL WMDCTWYSTG
MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV GMKCTRLGGD RETKSHASFA
GGVCFMSAGI SSLISTVWYT KEIIANFLDL TVPESNKHEP GGAIYIGFIS AMLLFISGMI
FCTSCIKRNP EARLDPPTQQ PISNTQLENN STHNLKDYV
