CLD22_HUMAN
ID CLD22_HUMAN Reviewed; 220 AA.
AC Q8N7P3;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Claudin-22;
GN Name=CLDN22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-220.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N7P3; Q8WTT0: CLEC4C; NbExp=3; IntAct=EBI-17766761, EBI-12913226;
CC Q8N7P3; P25025: CXCR2; NbExp=3; IntAct=EBI-17766761, EBI-2835281;
CC Q8N7P3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-17766761, EBI-2820517;
CC Q8N7P3; P35372-10: OPRM1; NbExp=3; IntAct=EBI-17766761, EBI-12807478;
CC Q8N7P3; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-17766761, EBI-742688;
CC Q8N7P3; P55061: TMBIM6; NbExp=3; IntAct=EBI-17766761, EBI-1045825;
CC Q8N7P3; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-17766761, EBI-16746122;
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AC093844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK098064; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS43286.1; -.
DR RefSeq; NP_001104789.1; NM_001111319.1.
DR AlphaFoldDB; Q8N7P3; -.
DR SMR; Q8N7P3; -.
DR BioGRID; 119811; 7.
DR IntAct; Q8N7P3; 7.
DR STRING; 9606.ENSP00000318113; -.
DR TCDB; 1.H.1.1.3; the claudin tight junction (claudin1) family.
DR BioMuta; CLDN22; -.
DR DMDM; 62298548; -.
DR PaxDb; Q8N7P3; -.
DR PeptideAtlas; Q8N7P3; -.
DR PRIDE; Q8N7P3; -.
DR Antibodypedia; 55709; 74 antibodies from 19 providers.
DR DNASU; 53842; -.
DR Ensembl; ENST00000323319.7; ENSP00000318113.5; ENSG00000177300.7.
DR GeneID; 53842; -.
DR KEGG; hsa:53842; -.
DR MANE-Select; ENST00000323319.7; ENSP00000318113.5; NM_001111319.3; NP_001104789.1.
DR UCSC; uc010isa.2; human.
DR CTD; 53842; -.
DR DisGeNET; 53842; -.
DR GeneCards; CLDN22; -.
DR HGNC; HGNC:2044; CLDN22.
DR HPA; ENSG00000177300; Tissue enriched (salivary).
DR neXtProt; NX_Q8N7P3; -.
DR OpenTargets; ENSG00000177300; -.
DR PharmGKB; PA26570; -.
DR VEuPathDB; HostDB:ENSG00000177300; -.
DR eggNOG; ENOG502RSH3; Eukaryota.
DR GeneTree; ENSGT00940000162234; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; Q8N7P3; -.
DR OMA; QTQDHHQ; -.
DR OrthoDB; 1368971at2759; -.
DR PhylomeDB; Q8N7P3; -.
DR TreeFam; TF331936; -.
DR PathwayCommons; Q8N7P3; -.
DR Reactome; R-HSA-420029; Tight junction interactions.
DR SignaLink; Q8N7P3; -.
DR BioGRID-ORCS; 53842; 15 hits in 989 CRISPR screens.
DR GeneWiki; CLDN22; -.
DR GenomeRNAi; 53842; -.
DR Pharos; Q8N7P3; Tdark.
DR PRO; PR:Q8N7P3; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N7P3; protein.
DR Bgee; ENSG00000177300; Expressed in olfactory segment of nasal mucosa and 77 other tissues.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..220
FT /note="Claudin-22"
FT /id="PRO_0000144785"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 111
FT /note="Q -> L (in Ref. 2; AK098064)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 220 AA; 24509 MW; 0DBB146E10EBE91D CRC64;
MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV
GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI
LGGILSWASG VTALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG
CLLHCAACSS HAPLASGHYA VAQTQDHHQE LETRNTNLKH
