ID   ACI_MACGN               Reviewed;           3 AA.
AC   P84761;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   29-SEP-2021, entry version 18.
DE   RecName: Full=Angiotensin-1-converting enzyme inhibitory peptide;
OS   Macrocybe gigantea (Giant mushroom) (Tricholoma giganteum).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Catathelasmataceae; Macrocybe.
OX   NCBI_TaxID=1491104;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RX   PubMed=15165718; DOI=10.1016/j.peptides.2004.01.015;
RA   Hyoung Lee D., Ho Kim J., Sik Park J., Jun Choi Y., Soo Lee J.;
RT   "Isolation and characterization of a novel angiotensin I-converting enzyme
RT   inhibitory peptide derived from the edible mushroom Tricholoma giganteum.";
RL   Peptides 25:621-627(2004).
CC   -!- FUNCTION: Inhibits competitively angiotensin I-converting enzyme.
CC       Administration to hypertensive rats at a dosage of 1 mg/kg results in a
CC       decrease in blood pressure. {ECO:0000269|PubMed:15165718}.
CC   -!- MASS SPECTROMETRY: Mass=301; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:15165718};
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DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IDA:UniProtKB.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor.
FT   PEPTIDE         1..3
FT                   /note="Angiotensin-1-converting enzyme inhibitory peptide"
FT                   /id="PRO_0000076168"
SQ   SEQUENCE   3 AA;  301 MW;  776B181000000000 CRC64;
     GEP