CLD23_HUMAN
ID CLD23_HUMAN Reviewed; 292 AA.
AC Q96B33; Q08AJ3;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Claudin-23;
GN Name=CLDN23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12736707;
RA Katoh M., Katoh M.;
RT "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer,
RT is a novel member of CLAUDIN gene family.";
RL Int. J. Mol. Med. 11:683-689(2003).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96B33; Q96L08: SUSD3; NbExp=3; IntAct=EBI-18201031, EBI-18194029;
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in germinal center B-cells, placenta,
CC stomach as well as in colon tumor. {ECO:0000269|PubMed:12736707}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; BC125148; AAI25149.1; -; mRNA.
DR EMBL; BC125149; AAI25150.1; -; mRNA.
DR CCDS; CCDS55195.1; -.
DR RefSeq; NP_919260.2; NM_194284.2.
DR AlphaFoldDB; Q96B33; -.
DR SMR; Q96B33; -.
DR BioGRID; 126468; 2.
DR IntAct; Q96B33; 1.
DR STRING; 9606.ENSP00000428780; -.
DR TCDB; 1.H.1.1.4; the claudin tight junction (claudin1) family.
DR iPTMnet; Q96B33; -.
DR PhosphoSitePlus; Q96B33; -.
DR SwissPalm; Q96B33; -.
DR BioMuta; CLDN23; -.
DR DMDM; 47605532; -.
DR EPD; Q96B33; -.
DR MassIVE; Q96B33; -.
DR PaxDb; Q96B33; -.
DR PeptideAtlas; Q96B33; -.
DR PRIDE; Q96B33; -.
DR ProteomicsDB; 76039; -.
DR Antibodypedia; 52870; 122 antibodies from 22 providers.
DR DNASU; 137075; -.
DR Ensembl; ENST00000519106.2; ENSP00000428780.1; ENSG00000253958.2.
DR Ensembl; ENST00000644143.2; ENSP00000495091.1; ENSG00000285098.2.
DR GeneID; 137075; -.
DR KEGG; hsa:137075; -.
DR MANE-Select; ENST00000519106.2; ENSP00000428780.1; NM_194284.3; NP_919260.2.
DR UCSC; uc003wsi.4; human.
DR CTD; 137075; -.
DR DisGeNET; 137075; -.
DR GeneCards; CLDN23; -.
DR HGNC; HGNC:17591; CLDN23.
DR HPA; ENSG00000253958; Tissue enhanced (stomach).
DR MIM; 609203; gene.
DR neXtProt; NX_Q96B33; -.
DR OpenTargets; ENSG00000253958; -.
DR PharmGKB; PA134961253; -.
DR VEuPathDB; HostDB:ENSG00000253958; -.
DR eggNOG; ENOG502RYXX; Eukaryota.
DR GeneTree; ENSGT00390000006975; -.
DR HOGENOM; CLU_089834_0_0_1; -.
DR InParanoid; Q96B33; -.
DR OMA; WDICREQ; -.
DR OrthoDB; 1032461at2759; -.
DR PhylomeDB; Q96B33; -.
DR TreeFam; TF331936; -.
DR PathwayCommons; Q96B33; -.
DR Reactome; R-HSA-420029; Tight junction interactions.
DR SignaLink; Q96B33; -.
DR BioGRID-ORCS; 137075; 11 hits in 1066 CRISPR screens.
DR GenomeRNAi; 137075; -.
DR Pharos; Q96B33; Tbio.
DR PRO; PR:Q96B33; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96B33; protein.
DR Bgee; ENSG00000253958; Expressed in mucosa of transverse colon and 91 other tissues.
DR Genevisible; Q96B33; HS.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..292
FT /note="Claudin-23"
FT /id="PRO_0000144787"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 222..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 210
FT /note="V -> M (in dbSNP:rs12548737)"
FT /id="VAR_059219"
SQ SEQUENCE 292 AA; 31915 MW; D383B139905B8884 CRC64;
MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE
RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL GVRCWQDEPN FVLAGLSGVV
LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS PVTVQVSYSL VLGYLGSCLL LLGGFSLALS
FAPWCDERCR RRRKGPSAGP RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK
PKPKVGFPMP RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL
