CLD24_HUMAN
ID CLD24_HUMAN Reviewed; 220 AA.
AC A6NM45; F5H040;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Putative claudin-24 {ECO:0000305};
DE AltName: Full=Claudin-21 {ECO:0000312|HGNC:HGNC:37200};
GN Name=CLDN24 {ECO:0000312|HGNC:HGNC:37200};
GN Synonyms=CLDN21 {ECO:0000312|HGNC:HGNC:37200};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC093844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54824.1; -.
DR RefSeq; NP_001172078.1; NM_001185149.1.
DR AlphaFoldDB; A6NM45; -.
DR SMR; A6NM45; -.
DR STRING; 9606.ENSP00000438400; -.
DR BioMuta; CLDN24; -.
DR PaxDb; A6NM45; -.
DR PeptideAtlas; A6NM45; -.
DR PRIDE; A6NM45; -.
DR Antibodypedia; 71072; 1 antibodies from 1 providers.
DR DNASU; 100132463; -.
DR Ensembl; ENST00000541814.1; ENSP00000438400.1; ENSG00000185758.9.
DR GeneID; 100132463; -.
DR KEGG; hsa:100132463; -.
DR MANE-Select; ENST00000541814.1; ENSP00000438400.1; NM_001185149.1; NP_001172078.1.
DR UCSC; uc021xva.1; human.
DR CTD; 100132463; -.
DR GeneCards; CLDN24; -.
DR HGNC; HGNC:37200; CLDN24.
DR HPA; ENSG00000185758; Not detected.
DR neXtProt; NX_A6NM45; -.
DR OpenTargets; ENSG00000185758; -.
DR VEuPathDB; HostDB:ENSG00000185758; -.
DR eggNOG; ENOG502RSH3; Eukaryota.
DR GeneTree; ENSGT00940000162234; -.
DR InParanoid; A6NM45; -.
DR OMA; FPDVMPR; -.
DR OrthoDB; 1368971at2759; -.
DR PhylomeDB; A6NM45; -.
DR TreeFam; TF331936; -.
DR BioGRID-ORCS; 100132463; 11 hits in 986 CRISPR screens.
DR GenomeRNAi; 100132463; -.
DR Pharos; A6NM45; Tdark.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; A6NM45; protein.
DR Bgee; ENSG00000185758; Expressed in granulocyte and 48 other tissues.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 5: Uncertain;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..220
FT /note="Putative claudin-24"
FT /id="PRO_0000320201"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 18
FT /note="L -> F (in dbSNP:rs7688467)"
FT /id="VAR_055660"
SQ SEQUENCE 220 AA; 24421 MW; 57AE200093A81845 CRC64;
MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV
GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI
LGGILSWASG ITALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG
CLLNCAACSS HAPLALGHYA VAQMQTQCPY LEDGTADPQV
