CLD25_HUMAN
ID CLD25_HUMAN Reviewed; 229 AA.
AC C9JDP6;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Putative claudin-25;
GN Name=CLDN25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AP003170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67230.1; -; Genomic_DNA.
DR CCDS; CCDS44736.1; -.
DR RefSeq; NP_001094859.1; NM_001101389.1.
DR AlphaFoldDB; C9JDP6; -.
DR SMR; C9JDP6; -.
DR STRING; 9606.ENSP00000396304; -.
DR BioMuta; CLDN25; -.
DR PaxDb; C9JDP6; -.
DR PRIDE; C9JDP6; -.
DR Antibodypedia; 56622; 54 antibodies from 12 providers.
DR DNASU; 644672; -.
DR Ensembl; ENST00000453129.2; ENSP00000396304.2; ENSG00000228607.2.
DR GeneID; 644672; -.
DR KEGG; hsa:644672; -.
DR MANE-Select; ENST00000453129.3; ENSP00000396304.2; NM_001101389.1; NP_001094859.1.
DR UCSC; uc009yyw.2; human.
DR CTD; 644672; -.
DR GeneCards; CLDN25; -.
DR HGNC; HGNC:37218; CLDN25.
DR HPA; ENSG00000228607; Not detected.
DR neXtProt; NX_C9JDP6; -.
DR OpenTargets; ENSG00000228607; -.
DR PharmGKB; PA165543379; -.
DR VEuPathDB; HostDB:ENSG00000228607; -.
DR eggNOG; ENOG502SNF0; Eukaryota.
DR GeneTree; ENSGT00940000163940; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; C9JDP6; -.
DR OMA; VPLWKNL; -.
DR OrthoDB; 1368971at2759; -.
DR PhylomeDB; C9JDP6; -.
DR TreeFam; TF331936; -.
DR PathwayCommons; C9JDP6; -.
DR BioGRID-ORCS; 644672; 7 hits in 1061 CRISPR screens.
DR GenomeRNAi; 644672; -.
DR Pharos; C9JDP6; Tdark.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; C9JDP6; protein.
DR Bgee; ENSG00000228607; Expressed in olfactory segment of nasal mucosa and 4 other tissues.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070160; C:tight junction; IDA:ARUK-UCL.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
PE 5: Uncertain;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..229
FT /note="Putative claudin-25"
FT /id="PRO_0000395403"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 219
FT /note="H -> Y (in dbSNP:rs35111413)"
FT /id="VAR_063401"
SQ SEQUENCE 229 AA; 25394 MW; 86EC6AEE87BCA151 CRC64;
MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI WEVCVDREEV
ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF GSECFQFHRI RWVFKRRLGL
LGRTLEASAS ATTLLPVSWV AHATIQDFWD DSIPDIIPRW EFGGALYLGW AAGIFLALGG
LLLIFSACLG KEDVPFPLMA GPTVPLSCAP VEESDGSFHL MLRPRNLVI
