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CLD34_HUMAN
ID   CLD34_HUMAN             Reviewed;         214 AA.
AC   H7C241;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Claudin-34 {ECO:0000305};
GN   Name=CLDN34 {ECO:0000312|HGNC:HGNC:51259};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250|UniProtKB:O88552}.
CC   -!- SUBUNIT: Can form homo- and heteropolymers with other CLDN.
CC       {ECO:0000250|UniProtKB:O88552}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:O88552}. Cell membrane
CC       {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O88552}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; AC002365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS75951.1; -.
DR   RefSeq; NP_001182010.1; NM_001195081.1.
DR   AlphaFoldDB; H7C241; -.
DR   SMR; H7C241; -.
DR   STRING; 9606.ENSP00000403980; -.
DR   BioMuta; CLDN34; -.
DR   PaxDb; H7C241; -.
DR   PRIDE; H7C241; -.
DR   DNASU; 100288814; -.
DR   Ensembl; ENST00000445307.4; ENSP00000403980.3; ENSG00000234469.4.
DR   GeneID; 100288814; -.
DR   KEGG; hsa:100288814; -.
DR   MANE-Select; ENST00000445307.4; ENSP00000403980.3; NM_001195081.2; NP_001182010.1.
DR   UCSC; uc022bsu.2; human.
DR   CTD; 100288814; -.
DR   GeneCards; CLDN34; -.
DR   HGNC; HGNC:51259; CLDN34.
DR   HPA; ENSG00000234469; Tissue enhanced (testis).
DR   neXtProt; NX_H7C241; -.
DR   VEuPathDB; HostDB:ENSG00000234469; -.
DR   eggNOG; ENOG502S127; Eukaryota.
DR   GeneTree; ENSGT00390000005717; -.
DR   HOGENOM; CLU_084794_0_0_1; -.
DR   InParanoid; H7C241; -.
DR   OMA; LGLIQWR; -.
DR   OrthoDB; 1362816at2759; -.
DR   PathwayCommons; H7C241; -.
DR   BioGRID-ORCS; 100288814; 2 hits in 172 CRISPR screens.
DR   Pharos; H7C241; Tdark.
DR   PRO; PR:H7C241; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; H7C241; protein.
DR   Bgee; ENSG00000234469; Expressed in left testis and 32 other tissues.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   InterPro; IPR006187; Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..214
FT                   /note="Claudin-34"
FT                   /id="PRO_0000433220"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..214
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   214 AA;  24226 MW;  6E9D8052B77F6896 CRC64;
     MVWFCNSADC QFSVFALTTI GWILSSTSTG LVEWRIWYMK DTSLYPPGIA CVGIFRVCIY
     RRRTNSTTTK FCYRYSYQDT FLPFEISMAQ RFLLTASIFG FFGRAFNMFA LRNMSMRMFE
     EDTYNSFVVS GILNIAAGVF NLIAVLQNYD AVINSQGITF LPSLQMPFKP DVQEVGTAIQ
     VAGIGVLPML LTGMFSLFYK CPPYGQVHPG ISEM
 
 
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